Results 121 to 130 of about 131,699 (232)

Photogenerated Oxetanes as a Gateway to Uphill Cyclopropanation

Angewandte Chemie International Edition, EarlyView.
An atom‐economical route to densely functionalized cyclopropanes from furans and photochemically activated aldehydes is enabled by a unique oxetane‐to‐cyclopropane rearrangement. These cyclopropanes can be used to access complex bioactive scaffolds and serve as a platform for asymmetric cyclopropane synthesis.
Tim Köglmeier, Thomas J. Tiefel, Oliver Reiser   +2 more
wiley   +1 more source

Crystal structure of 2-S-benzyl-5-phenyl-1-(1-thia-3,4-diazacyclopenta-2,4-diene), C15H12N2S2

Zeitschrift für Kristallographie - New Crystal Structures, 2000
Tarafder M. T. H., Azahari K., Crouse K. A., Yamin B. M., Raj S. S. S., Razak I. A., Fun H.-K.   +6 more
doaj   +1 more source

Mutation of active site glutamate in serine hydroxymethyltransferase allows trapping a reactive intermediate: a combined neutron and X-ray crystallography study. [PDF]

RSC Adv
Drago VN, Phillips RS, Kovalevsky A.
europepmc   +1 more source

Expression, purification, and crystallization of recombinant human ABL-1 kinase for X-ray crystallography. [PDF]

Turk J Chem
Irgit A, Çiftçi H, Demirci H.
europepmc   +1 more source

Mapping protein dynamics at high spatial resolution with temperature-jump X-ray crystallography. [PDF]

Nat Chem, 2023
Wolff AM, Nango E, Young ID, Brewster AS, Kubo M, Nomura T, Sugahara M, Owada S, Barad BA, Ito K, Bhowmick A, Carbajo S, Hino T, Holton JM, Im D, O'Riordan LJ, Tanaka T, Tanaka R, Sierra RG, Yumoto F, Tono K, Iwata S, Sauter NK, Fraser JS, Thompson MC.   +24 more
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

Sample delivery methods for protein X-ray crystallography with a special focus on sample consumption. [PDF]

Nat Commun
Manna A, Doppler D, Sripati MP, Sonker M, Ros A.   +4 more
europepmc   +1 more source

X-ray crystallography reveals insulin lisargine structure and mechanisms of glucose regulation. [PDF]

Sci Rep
Zhu Z, Zheng Z, Wang H, Wang L, Yang Q, Wei Z, Wang P.   +6 more
europepmc   +1 more source

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Coupled on-line in crystallo UV-Vis absorption spectroscopy and X-ray crystallography to compare specific radiation damage in metal-containing proteins at room versus cryogenic temperature. [PDF]

Acta Crystallogr D Struct Biol
Caramello N, Rose SL, Mathieu E, Petit L, Tews I, Engilberge S, Royant A.   +6 more
europepmc   +1 more source