Nanometer Layer Coating to Lactose Particles for Optimization of Dexamethasone Pulmonary Delivery
Advanced Science, EarlyView.Nanometer layer coating (NLC) was investigated and its mechanism illustrated by advanced characterization techniques. The effects and application for the inhalation of dexamethasone (DEX) were demonstrated through in vitro and in vivo evaluation. This approach increased DEX bioavailability and enabled the dose to be reduced to 1/30 of the intravenous ...
Qin Nie +11 more
wiley +1 more source
(E)-4-Methoxy-N′-(2,4,5-trimethoxybenzylidene)benzohydrazide hemihydrate
Acta Crystallographica Section E, 2014 The title compound crystallizes as a hemihydrate, C18H20N2O5·0.5H2O. The molecule exists in an E conformation with respect to the C=N imine bond. The 4-methoxyphenyl unit is disordered over two sets of sites with a refined occupancy ratio of 0.54 (2):0 ...
Suchada Chantrapromma +4 more
doaj +1 more source
X-ray structure of a putative reaction intermediate of 5-aminolaevulinic acid dehydratase
, 2003 The X-ray structure of yeast 5-aminolaevulinic acid dehydratase, in which the catalytic site of the enzyme is complexed with a putative cyclic intermediate composed of both substrate moieties, has been solved at 0.16 nm (1.6 Å) resolution.
Youell, J.H. +8 more
core +1 more source
Drought Stress Mediated Changes in Food Crops: Mechanisms and Remediation Strategies
Advanced Science, EarlyView.This work presents a multi‐scale framework for flavonoid‐mediated drought tolerance in staple food crops, integrating ROS redox regulation, antioxidant defense, rhizosphere microbial interactions, and sustainable agronomic practices. This interdisciplinary model provides core insights to develop climate‐resilient cropping systems and enhance global ...
Xiaoyi Duan +5 more
wiley +1 more source
(E)-2-[4-(Diethylamino)styryl]-1-methylquinolin-1-ium 4-chlorobenzenesulfonate monohydrate
Acta Crystallographica Section E, 2014 The asymmetric unit of the title hydrated salt, C22H25N2+·C6H4ClO3S−·H2O, comprises two 2-[4-(diethylamino)styryl]-1-methylquinolin-1-ium cations, two 4-chlorobenzenesulfonate anions and two solvent water molecules.
Suchada Chantrapromma +4 more
doaj +1 more source
Enhanced colour encoding of materials discrimination information for multiple view dual-energy x-ray imaging [PDF]
, 2009 This thesis reports an investigation into dual-energy X-ray discrimination techniques. These techniques are designed to provide colour-coded materials discrimination information in a sequence of perspective images exhibiting sequential parallax.
Wang, X
core
Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation
Advanced Science, EarlyView.Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu +8 more
wiley +1 more source
Insights into the catalytic mechanisms of a 3-ketosteroid Δ1-dehydrogenase and a β-xylosidase obtained from 3D structures [PDF]
, 2016 Seeing is understanding. In many instances, seeing is the best way to understand natural phenomena. X-ray crystallography is among the most powerful methods to visualize 3D structures of proteins and nucleic acids at the atomic level.
Rohman, Ali
core +12 more sources
Magnetic Water Cleaning of Estrogens via Tight yet Dynamic Binding to Nanoparticles
Advanced Science, EarlyView.Micropollution is one of the big challenges humanity faces with estrogen hormones being emerging pollutants of concern. Here, a supramolecular design strategy is presented that generates a simple nano‐adsorbent material to magnetically remove low‐concentrated estrogens from water.
Lukas Müller +25 more
wiley +1 more source
Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein. An X-ray Crystallography Study
, 2004 Ligand Binding to Chicken Liver Basic Fatty acid-Binding Protein.
BOVI, Michele +5 more
core +1 more source