Results 211 to 220 of about 132,637 (291)

Room-temperature X-ray fragment screening with serial crystallography

S. Guenther, Alke Meents
openalex   +1 more source

Twisted 1‐ and 2‐Azaperopyrenes: Synthesis, Structure, and Properties

Chemistry – A European Journal, EarlyView.
ABSTRACT A synthesis of hitherto unknown 1‐ and 2‐azaperopyrenes, twisted nitrogen‐doped peropyrenes, is reported. The synthesis is based on a Brønsted acid‐mediated benzannulation of alkynes. Key alkyne intermediates are synthesized via two complementary routes, including a Pd/C‐catalyzed, copper‐ and amine‐free Sonogashira‐type coupling of (hetero ...
Ricardo Molenda, Arpine Vardanyan, Alexander Villinger, Peter Ehlers, Peter Langer   +4 more
wiley   +1 more source

Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. [PDF]

J Chem Inf Model
Meeks KR, Ji J, Protopopov MV, Tarkhanova OO, Moroz YS, Tanner JJ.   +5 more
europepmc   +1 more source

Synthesis and Glycosidase Inhibition Studies of Novel Exoglycals Targeting GH3 Family Enzymes: Insights from Comparative Analysis with Macrolide Antibiotics

Chemistry – A European Journal, EarlyView.
A series of structurally diverse exoglycals was synthesized using a modified Julia‐olefination approach from sugar‐derived precursors. These glycosidase transition‐state mimics were further diversified via CuAAC chemistry to yield triazole‐conjugated analogues.
Elisa Ospanow, Oscar L. Alferez, David L. Jakeman   +2 more
wiley   +1 more source

Rh‐Catalyzed [2 + 2 + 2] Cycloaddition of Linked Bis(Diynes) Ar‐C≡C‐C≡C‐(CH2)3‐C≡C‐C≡C‐Ar With Quinones: Synthesis and Photophysical Properties of Bis(Arylethynyl)‐Naphthoquinones and Anthraquinones

Chemistry – A European Journal, EarlyView.
We report the synthesis bis(arylethynyl)naphtho‐ and anthraquinones via Rh(I)‐catalyzed [2 + 2 + 2] cycloaddition reactions. The substrate scope of both quinones and linked bis‐diynes was explored. Microwave irradiation remarkably enhanced yields.
Luana A. Machado, Jianhua Han, Fábio G. Delolo, Joyce C. Oliveira, Breno U. Abreu, Hállen D. R. Calado, Joannes Krebs, Leibo Tan, Qing Ye, Tobias Groß, Christoph Lambert, Camille Latouche, Abdou Boucekkine, Jean‐François Halet, Holger Braunschweig, Todd B. Marder, Eufrânio N. da Silva Júnior   +16 more
wiley   +1 more source

Architecture of full-length type I modular polyketide synthases revealed by X-ray crystallography, cryo-electron microscopy, and AlphaFold2. [PDF]

Nat Prod Rep
Bagde SR, Kim CY.
europepmc   +1 more source

Regio‐ and Diastereoselective C–C Silylation of Cyclopropyl Acetates Harnessing Fluorinated Poly(pyridyl)Borate Rhodium Catalysts

Chemistry – A European Journal, EarlyView.
Fluorinated poly(pyridyl)borates have been utilized to stabilize rhodium‐diene complexes and as supporting ligands in rhodium‐catalyzed redox‐neutral C–C silylation of cyclopropyl acetates, producing silicon‐containing heterocyclic products, dioxasilolanes.
Vo Quang Huy Phan, Suman Das Adhikary, Junha Jeon, H. V. Rasika Dias   +3 more
wiley   +1 more source

KINNTREX: a neural network to unveil protein mechanisms from time-resolved X-ray crystallography. [PDF]

IUCrJ
Biener G, Malla TN, Schwander P, Schmidt M.   +3 more
europepmc   +1 more source

Experimental X-ray Crystallography [PDF]

Nature, 1963
openaire   +1 more source