Results 51 to 60 of about 30,167,678 (291)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

3D ultrastructural organization of whole Chlamydomonas reinhardtii cells studied by nanoscale soft x-ray tomography [PDF]

, 2012
The complex architecture of their structural elements and compartments is a hallmark of eukaryotic cells. The creation of high resolution models of whole cells has been limited by the relatively low resolution of conventional light microscopes and the ...
Achilleas S. Frangakis, Hummel, E., Michael Kunz, Eric Hummel, Werner, Stephan, Basel Tarek, Frangakis, Achilleas S., Gerd Schneider, Frangakis, A.S., Tarek, B., Schneider, G., Westermann, B., Basel Tarek (107662), Michael Kunz (107666), Hummel, Eric, Werner, S., Stephan Werner, Tarek, Basel, Benedikt Westermann (107668), Guttmann, Peter, Westermann, Benedikt, Benedikt Westermann, Peter Guttmann, Stephan Werner (107660), Gerd Schneider (107664), Kunz, Michael, Achilleas S. Frangakis (107667), Peter Guttmann (107658), Kunz, M., Achilleas S Frangakis, Eric Hummel (107656), Guttmann, P., Schneider, Gerd   +32 more
core   +2 more sources

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

Evidence for GeV Gamma-Ray Emission from Intense GRB 240529A During the Afterglow’s Shallow Decay Phase

The Astrophysical Journal
X-ray light curves of gamma-ray burst (GRB) afterglows exhibit various features, with the shallow decay phase being particularly puzzling. While some studies report the absence of the X-ray shallow decay for hyperenergetic GRBs, recently discovered GRB ...
Kenta Terauchi, Tomohiko Oka, Katsuaki Asano   +2 more
doaj   +1 more source

Crack formation in vacuum concrete

Journal of Civil Engineering and Management, 2002
The reasons of crack formation in vacuum concrete floors with reinforcing mineral wear-resistant coating were investigated. The main reasons of crack formation are connected with low concrete strength due to the lack of water for cement hydration, the ...
Grigory Yakovlev, Nikolai Khokhriakov
doaj   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Invisible but not inaccessible—Revealing transient oligomers formed by intrinsically disordered proteins with solution NMR and complementary methods

FEBS Letters, EarlyView.
Transient oligomers formed by intrinsically disordered proteins may be ‘invisible’ to direct detection yet remain accessible to solution NMR through equilibrium‐exchange measurements and pressure‐jump experiments. Complementary methods report on mass, stoichiometry, selected distance distributions, morphology, and internal packing.
Martin D. Gelenter, Ad Bax
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Quantitative chemical analysis of pickling solutions by x-ray fluorescence spectrometry

, 2019
A quantitative analytical method of chlorine and iron in hydrochloric pickling solutions by x-ray spectrometry in atmospheric He mode is proposed. This work is concerned with the replacement of the wet chemical analyses of pickling solutions with rapid ...
Na, HG, Min, DJ, Jung, SM, Cho, YM
core   +1 more source