Results 71 to 80 of about 1,474,810 (297)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Fall back accretion and energy injections in gamma-ray bursts

, 2014
Intense flares that occur at late times relative to the prompt phase have been observed by the $Swift$ satellite in the X-ray afterglows of gamma-ray bursts (GRBs).
Coward, D. M., Gendre, B., Howell, E. J., Huang, Y. F., Stratta, G., Wu, X. F., Yu, Y. B.   +6 more
core   +2 more sources

Metallic 1T Phase, 3d1 Electronic Configuration and Charge Density Wave Order in Molecular Beam Epitaxy Grown Monolayer Vanadium Ditelluride. [PDF]

, 2019
We present a combined experimental and theoretical study of monolayer vanadium ditelluride, VTe2, grown on highly oriented pyrolytic graphite by molecular-beam epitaxy.
Bussolotti, Fabio, Chen, Wei, de Jong, Michel P, Feng, Yuan Ping, Goh, Johnson, Morton, Simon A, N'Diaye, Alpha T, Wee, Andrew TS, Wong, Ping Kwan Johnny, Yin, Xinmao, Zhang, Lei, Zhang, Wen, Zhou, Jun   +12 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

EFEITO DO DIOXIDO DE CARBONO SOBRE A ESTABILIDADE DA FASE Ca2Fe2O5 APLICADA NO PROCESSO DE DEGRADAÇÃO FOTOCATALITICO DO AZUL DE METILENO

Química Nova, 2015
Solid samples containing a Ca2Fe2O5 phase were synthesized using the Pechini method. The samples were characterized using X-ray diffraction, thermogravimetric analysis, differential thermal analysis, X-ray fluorescence, nitrogen adsorption/desorption ...
Erandir Brasil da Silva, Antoninho Valentini   +1 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

A Phase-resolved View of Millihertz Quasiperiodic Oscillations in the Ultraluminous X-Ray Source M51 ULX-7: Evidence for a Magnetically Truncated Disk and Geometrical Beaming

The Astrophysical Journal
X-ray quasiperiodic oscillations (QPOs) are commonly observed in Galactic X-ray binaries and extragalactic ultraluminous X-ray sources (ULXs). In this study, we perform a phase-resolved analysis of recently discovered X-ray mHz QPOs in M51 ULX-7.
Qing-Cang Shui, Shu Zhang, Hua Feng, Yu-Peng Chen, Shuang-Nan Zhang, Jing-Qiang Peng   +5 more
doaj   +1 more source

Timing Analysis of Black Hole X-Ray Binaries with Insight-HXMT

Galaxies
The Hard X-ray Modulation Telescope (HXMT), China’s first X-ray astronomy satellite, has significantly contributed to the study of fast variability in black hole X-ray binaries through its broad energy coverage (1–250 keV), high timing resolution, and ...
Haifan Zhu, Wei Wang
doaj   +1 more source

Detection of X-ray periodicity from a new eclipsing polar candidate XGPS-I J183251-100106

, 2012
We report the results from a detailed analysis of an archival XMM-Newton observation of the X-ray source XGPS-I J183251-100106, which has been suggested as a promising magnetic cataclysmic variable candidate based on its optical properties.
Chou, Y., Hu, C. P., Hui, C. Y., Lin, L. C. C., Seo, K. A.   +4 more
core   +1 more source