Results 41 to 50 of about 1,181,189 (249)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Growth Differentiation Factor 15 Elevation in the Central Nervous System Is Associated With Failure to Thrive in Alexander Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Alexander disease (AxD) is a severe neurodegenerative disorder caused by gain‐of‐function mutations in the gene for GFAP, which lead to protein aggregation and a primary astrocytopathy. Symptoms vary, but failure to thrive (FTT) and frequent emesis are common and cause significant morbidity. Here we investigate GDF15, a member of the
Tracy L. Hagemann, Michelle M. Sonsalla, Cora Luzinski, Fernando Zacahua, David A. Harris, Dudley W. Lamming, Albee Messing   +6 more
wiley   +1 more source

Methods for Estimating Fluxes and Absorptions of Faint X-ray Sources

, 2009
X-ray sources with very few counts can be identified with low-noise X-ray detectors such as ACIS onboard the Chandra X-ray Observatory. These sources are often too faint for parametric spectral modeling using well-established methods such as fitting with
Arnaud, Bevington, Broos, Broos, Drake, Eric D. Feigelson, Feigelson, Feigelson, Gagné, Getman, Getman, Gordon P. Garmire, Hong, Imanishi, Konstantin V. Getman, Leisa K. Townsley, Maggio, Muno, Patrick S. Broos, Preibisch, Press, Prestwich, Saez, Sarazin, Shemmer, Smith, Townsley, Wilms, Winter   +28 more
core   +1 more source

Physician Referral Patterns to Physical Therapists for Managing Knee Osteoarthritis: A Retrospective Analysis of Electronic Health Records from an Integrated Health System

Arthritis Care &Research, Accepted Article.
Objectives This study aims to describe the frequency and timing of physician referrals to physical therapists (PT) and other treatments prescribed over 12 months in patients with recent onset of knee osteoarthritis (KOA). The study also aims to identify determinants of early PT referrals.
Samannaaz S. Khoja, Joel M. Stevans, Gustavo J. Almeida, Clair Smith, Janet K. Freburger   +4 more
wiley   +1 more source

Quick X-ray microtomography using a laser-driven betatron source

, 2017
Laser-driven X-ray sources are an emerging alternative to conventional X-ray tubes and synchrotron sources. We present results on microtomographic X-ray imaging of a cancellous human bone sample using synchrotron-like betatron radiation.
Ding, H., Döpp, A., Gilljohann, M., Goetzfried, J., Hehn, L., Karsch, S., Pfeiffer, F., Schindler, S., Wenz, J.   +8 more
core   +1 more source

The effect of foot orthoses on midfoot pain and the volume of bone marrow lesions in the midfoot: a randomized mechanism of action study

Arthritis Care &Research, Accepted Article.
Objective Foot orthoses are thought to improve pain by potentially modifying internal mechanical forces. To test this, we explored whether foot orthoses can modify patterns of bone marrow lesions (BMLs) in people with midfoot pain. Methods Forty‐two people were recruited with midfoot pain and MRI‐confirmed midfoot BMLs.
Jill Halstead, Anne‐Maree Keenan, Philip G. Conaghan, Dennis McGonagle, Anthony C. Redmond   +4 more
wiley   +1 more source

The Chandra XBootes Survey - III: Optical and Near-IR Counterparts

, 2005
The XBootes Survey is a 5-ks Chandra survey of the Bootes Field of the NOAO Deep Wide-Field Survey (NDWFS). This survey is unique in that it is the largest (9.3 deg^2), contiguous region imaged in X-ray with complementary deep optical and near-IR ...
Alexey Vikhlinin, Almus T. Kenter, Arjun Dey, Benn C. R., Brian R. McNamara, Buell T. Jannuzi, Christine J. Jones, Christopher S. Kochanek, Daniel Fabricant, de Ruiter H. R., Fioc M., Giovanni G. Fazio, Hoopes C. G., Joan R. Najita, Joseph C. Shields, Kate Brand, Marcia Rieke, Michael J. I. Brown, Paul J. Green, Soifer B. T., Stephen S. Murray, William R. Forman   +21 more
core   +1 more source

Validation of a Genetic Risk Score Combined with Clinical Variables for Predicting Pulmonary Fibrosis in early Rheumatoid Arthritis

Arthritis Care &Research, Accepted Article.
Objectives Pulmonary fibrosis (PF) is a severe extra‐articular manifestation of rheumatoid arthritis (RA). The study aimed to externally validate a genetic risk score (GRS) and a combined risk score for predicting the risk of RA‐associated PF in an independent cohort of early‐RA patients. Methods This study utilized an inception cohort of 1118 patients
Mikael Brink, Austin Wheeler, Bryant R. England, Solbritt Rantapää‐Dahlqvist   +3 more
wiley   +1 more source

Spectral properties of XRBs in dusty early-type galaxies

, 2013
We present spectral properties of a total of 996 discrete X-ray sources resolved in a sample of 23 dusty early-type galaxies selected from different environments.
Bertola, Blanton, David, de Vaucouleurs, Fabbiano, Fabbiano, Finkelman, Finkelman, Finoguenov, Forbes, Forman, Giacconi, Gilfanov, Goudfrooij, Goudfrooij, Grimm, Gänsicke, Haberl, Humphrey, Humphrey, Irwin, Irwin, Jeltema, Kennicutt, Kim, Kim, Knapp, Kundu, Kundu, M.B. Pandge, M.K. Patil, Matsushita, N.D. Vagshette, Pandge, Patil, Peng, Prestwich, Randall, Sarazin, Sarazin, Sivakoff, Vagshette, van Dokkum   +42 more
core   +1 more source