Results 41 to 50 of about 30,807 (267)
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A Markedly Expanded Sample of Candidate X-Ray-emitting Isolated Neutron Stars
The Astrophysical JournalThe current sample of 12 radio-quiet isolated neutron stars that emit strongly in X-rays (XINSs) is both small and heterogeneous, limiting its usefulness for understanding the physics of neutron star atmospheres and cooling rates and for constraining the
Sebastian Demasi +2 more
doaj +1 more source
EROSITA: AGN SCIENCE, BACKGROUND DETERMINATION, AND OPTICAL FOLLOW-UP SPECTROSCOPY
Acta Polytechnica, 2013 More than 20 years after the highly impacting ROSAT all-sky survey in the soft X-ray spectral range, we are close to the next major X-ray all/sky surveys with eROSITA. eROSITA will be the primary instrument on-board the Russian “Spectrum–Roentgen–Gamma” (
Thomas Boller
doaj +1 more source
Measuring the Cosmic X-Ray Background in 3–20 KeV with Stray Light from NuSTAR
The Astronomical Journal, 2023 By characterizing the contribution of stray light to large data sets from the CXB Measurement X-ray observatory collected over 2012–2017, we report a measurement of the cosmic X-ray background (CXB) in the 3–20 keV energy range. These data represent ∼20%
Steven Rossland +15 more
doaj +1 more source
Surveys of X-Ray Sources [PDF]
Highlights of Astronomy, 1968 My assignment this afternoon is to review briefly the status of the observational work that has been accomplished since the last IAU discussion of X-ray astronomy which took place at the Liege Symposium 3 years ago. Essentially, the methods of observation have not changed in any significant way.
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Chandra X-Ray Observatory Observations of 13 Fermi LAT Sources
The Astrophysical JournalIn the latest data release from the Fermi Gamma-ray Space Telescope (the 4th Fermi LAT 14 yr Catalog, or 4FGL), more than 50% of the Galactic sources are yet to be identified.
Blagoy Rangelov +5 more
doaj +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
The Astrophysical Journal, 2023 We present X-ray spectral analysis of XMM-Newton and Chandra observations in the 31.3 deg ^2 Stripe-82X (S82X) field. Of the 6181 unique X-ray sources in this field, we analyze a sample of 2937 candidate active galactic nuclei (AGNs) with solid redshifts
Alessandro Peca +13 more
doaj +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source