Results 51 to 60 of about 378,234 (335)

A Search for Pulsars in Quiescent Soft X-Ray Transients. I [PDF]

, 2003
We have carried out a deep search at 1.4 GHz for radio pulsed emission from six soft X-ray transient sources observed during their X-ray quiescent phase. The commonly accepted model for the formation of the millisecond radio pulsars predicts the presence
Burderi L, Burgay M, Camilo F, Campana S, D'Amico N, Lyne AG, Manchester RN, Possenti A   +7 more
core   +3 more sources

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Delayed X-Ray Brightening Accompanied by Variable Ionized Absorption Following a Tidal Disruption Event

The Astrophysical Journal
Supermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers, M. Guolo, D. R. Pasham, E. R. Coughlin, F. Tombesi, Y. Yao, S. Gezari   +6 more
doaj   +1 more source

Live to Die Another Day: The Rebrightening of AT 2018fyk as a Repeating Partial Tidal Disruption Event

The Astrophysical Journal Letters, 2023
Stars that interact with supermassive black holes (SMBHs) can be either completely or partially destroyed by tides. In a partial tidal disruption event (TDE), the high-density core of the star remains intact, and the low-density outer envelope of the ...
T. Wevers, E. R. Coughlin, D. R. Pasham, M. Guolo, Y. Sun, S. Wen, P. G. Jonker, A. Zabludoff, A. Malyali, R. Arcodia, Z. Liu, A. Merloni, A. Rau, I. Grotova, P. Short, Z. Cao   +15 more
doaj   +1 more source

The XMM-Newton survey of the Small Magellanic Cloud: XMMUJ005011.2-730026 = SXP214, a Be/X-ray binary pulsar [PDF]

, 2011
In the course of the XMM-Newton survey of the Small Magellanic Cloud (SMC), a region to the east of the emission nebula N19 was observed in November 2009.
A. Tiengo, A. Udalski, Antoniou, Arnaud, Coe, Coe, Coe, Corbet, D. Burton, Diago, E. S. Bartlett, Eger, Evans, F. Haberl, Galache, Gregory, Haberl, Haberl, Hickox, J. L. Payne, Kato, Kurucz, L. J. Townsend, Liu, Liu, M. Ehle, M. Filipovic, M. J. Coe, Massey, McBride, McGregor, Negueruela, Okazaki, R. H. D. Corbet, R. Sturm, Russell, Schwering, Stanimirovic, Stella, Strüder, Sturm, Turner, Udalski, W. Pietsch, Wegner, Wilms, Zaritsky   +46 more
core   +2 more sources

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Follow the Mass—A Concordance Picture of Tidal Disruption Events

The Astrophysical Journal
Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj   +1 more source

The Chandra Local Volume Survey: The X-ray Point Source Catalog of NGC 300

, 2012
We present the source catalog of a new Chandra ACIS-I observation of NGC 300 obtained as part of the Chandra Local Volume Survey. Our 63 ks exposure covers ~88% of the D25 isophote (R~6.3 kpc) and yields a catalog of 95 X-ray point sources detected at ...
A. K. H. Kong, B. Binder, B. F. Williams, Belczynski, Binder, Binder, Blair, Broos, Colbert, D. R. Weisz, Dalcanton, Deharveng, E. D. Skillman, Eracleous, Freeman, Gibson, Gogarten, Hornschemeier, J. J. Dalcanton, Kilgard, Kim, Kong, Kong, Larsen, Lasota, Long, M. Eracleous, Maíz-Apellániz, Muñoz-Mateos, P. P. Plucinsky, Pannuti, Park, Plucinsky, Prestwich, S. F. Anderson, Singh, Skrutskie, Smith, Soria, T. J. Gaetz, Trudolyubov, Tüllmann, Vila-Costas, Williams, Williams, Wilms, Yi   +46 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Optical Appearance of Eccentric Tidal Disruption Events

The Astrophysical Journal Letters
Stars approaching supermassive black holes can be tidally disrupted. Despite being expected to emit X-rays, tidal disruption events (TDEs) have been largely observed in optical bands, which is poorly understood.
Fangyi (Fitz) Hu, Daniel J. Price, Ilya Mandel   +2 more
doaj   +1 more source