Results 51 to 60 of about 214,668 (294)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Follow the Mass—A Concordance Picture of Tidal Disruption Events

The Astrophysical Journal
Three recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Optical Appearance of Eccentric Tidal Disruption Events

The Astrophysical Journal Letters
Stars approaching supermassive black holes can be tidally disrupted. Despite being expected to emit X-rays, tidal disruption events (TDEs) have been largely observed in optical bands, which is poorly understood.
Fangyi (Fitz) Hu, Daniel J. Price, Ilya Mandel   +2 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

The Nature of Optical Afterglows without Gamma-Ray Bursts: Identification of AT2023lcr and Multiwavelength Modeling

The Astrophysical Journal
In the past few years, the improved sensitivity and cadence of wide-field optical surveys have enabled the discovery of several afterglows without associated detected gamma-ray bursts (GRBs).
Maggie L. Li, Anna Y. Q. Ho, Geoffrey Ryan, Daniel A. Perley, Gavin P. Lamb, Nayana A.J., Igor Andreoni, G. C. Anupama, Eric C. Bellm, Edo Berger, Joshua S. Bloom, Eric Burns, Ilaria Caiazzo, Poonam Chandra, Michael W. Coughlin, Kareem El-Badry, Matthew J. Graham, Mansi Kasliwal, Garrett K. Keating, S. R. Kulkarni, Harsh Kumar, Frank J. Masci, Richard A. Perley, Josiah Purdum, Ramprasad Rao, Antonio C. Rodriguez, Ben Rusholme, Nikhil Sarin, Jesper Sollerman, Gokul P. Srinivasaragavan, Vishwajeet Swain, Zachary Vanderbosch   +31 more
doaj   +1 more source

Packaging of Macroscopic Material Payloads: Needs, Challenges, Concepts, and Future Directions

Advanced Engineering Materials, EarlyView.
This review introduces a unified framework that decomposes any macroscopic packaging system into the payload, packaging material, and packaging strategy and combines them into a conceptual packaging equation: packaging strategy = payload + packaging material.
Venkata S. R. Jampani, Manos Anyfantakis
wiley   +1 more source

The Landscape of Collapsar Outflows: Structure, Signatures, and Origins of Einstein Probe Relativistic Supernova Transients

The Astrophysical Journal Letters
The Einstein Probe is revolutionizing time-domain astrophysics through the discovery of new classes of X-ray transients associated with broad-line Type Ic supernovae.
Ore Gottlieb
doaj   +1 more source

Absorption of Gamma-Ray Burst X-Ray Afterglows by the Missing Baryons: Confronting Observations with Cosmological Simulations

The Astrophysical Journal, 2023
A large fraction of the baryons at low redshift are undetected and likely reside in the tenuous, hot intergalactic medium (IGM). One way to probe the missing baryons is through their absorption of bright sources.
Matan Grauer, Ehud Behar
doaj   +1 more source

INTEGRAL observations of recurrent fast X-ray transient sources [PDF]

Astronomy & Astrophysics, 2005
Fast X-ray Transients (FXTs) are believed to be non-recurrent bright X-ray sources lasting less than a day and occuring at serendipitous positions, they can best detected and discovered by instruments having a sufficiently wide field of view and high sensitivity. The IBIS/ISGRI instrument onboard INTEGRAL is particularly suited to detect new or already
Sguera, V., Barlow, E.J., Bird, A.J., Clark, D.J., Dean, A.J., Hill, A.B., Moran, L., Shaw, S.E., Willis, D.R., Bazzano, A., Ubertini, P., Malizia, A.   +11 more
openaire   +2 more sources