Results 51 to 60 of about 29,884 (299)
The Astrophysical JournalWe report multiwavelength studies of the transient EP250916a, detected by the Einstein Probe on 2025 September 16. Located at low Galactic latitude, the source exhibited a rapid X-ray brightening, reaching an unabsorbed 0.5–10 keV flux of (6.4 ± 0.1 ...
Gaurava K. Jaisawal +9 more
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Ultra high energy gamma ray point sources and cosmic ray anisotropy [PDF]
, 1994 The experimental set-up at the Baksan Air Shower Array, used to detect air showers above ~0.2xl0(^14)eV, is described. An estimation of the angular resolution using the cosmic ray shadow of the Sun and the Moon gives a value of ~2.5˚ which is consistent ...
Graham, Lilian Joan, Graham, L.J
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The Astrophysical JournalSupermassive black holes can experience super-Eddington peak mass fallback rates following the tidal disruption of a star. The theoretical expectation is that part of the infalling material is expelled by means of an accretion disk wind, whose ...
T. Wevers +6 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Streaking and splashing: design of a grazing incidence x-ray streak camera and time-resolved measurements of the structure of water [PDF]
, 2006 The performance of cesium iodide photocathodes has been characterized for use with grazing incidence soft x-rays. The total electron yield and pulsed quantum efficiency has been measured in a reflection geometry as a function of photon energy (100 eV to ...
Lowney, Donnacha
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Follow the Mass—A Concordance Picture of Tidal Disruption Events
The Astrophysical JournalThree recent global simulations of tidal disruption events (TDEs) have produced, using different numerical techniques and parameters, very similar pictures of their dynamics.
Julian Krolik, Tsvi Piran, Taeho Ryu
doaj +1 more source
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Optically and x-ray selected galaxy groups at intermediate redshift [PDF]
, 2012 In this thesis I present the properties of two samples of galaxy groups containing 39 high quality X-ray selected systems and 38 optically (spectroscopically) selected systems in coincident spatial regions at 0 ...
Connelly, Jennifer L.
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Optical Appearance of Eccentric Tidal Disruption Events
The Astrophysical Journal LettersStars approaching supermassive black holes can be tidally disrupted. Despite being expected to emit X-rays, tidal disruption events (TDEs) have been largely observed in optical bands, which is poorly understood.
Fangyi (Fitz) Hu +2 more
doaj +1 more source