Results 81 to 90 of about 7,697,292 (326)

EGFR‐STAT3 activation provides a therapeutic rationale for targeting aggressive ETV1‐positive prostate cancer

open access: yesMolecular Oncology, EarlyView.
Cotargeting EGFR and STAT3 with Erlotinib and TTI‐101 impairs both 2D and 3D growth of ETV1‐overexpressing prostate cancer cells by disrupting a self‐sustaining ETV1–EGFR positive feedback loop that promotes EGFR and STAT3 expression and phosphorylation (activation).
Elsa Gomes Paiva   +5 more
wiley   +1 more source

Imprinting magnetic information in manganites with X-rays

open access: yes, 2012
The effect of x-rays on an orbital and charge ordered epitaxial film of a Pr$_{0.5}$Ca$_{0.5}$MnO$_{3}$ is presented. As the film is exposed to x-rays, the antiferromagnetic response increases and concomitantly the conductivity of the film improve. These
Garganourakis, M.   +8 more
core   +1 more source

The critical role of DNA damage‐inducible transcript 4 (DDIT4) in stemness character of leukemia cells and leukemia initiation

open access: yesMolecular Oncology, EarlyView.
Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li   +12 more
wiley   +1 more source

X rays test the Pauli exclusion principle

open access: yes, 2005
Since the publication of the models describing a small violation of the Pauli exclusion principle (PEP) there has been an explosion of word-wide interest in PEP tests and related theories.
Ignatiev, A. Yu.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

open access: yesMolecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak   +8 more
wiley   +1 more source

A study on role of chest X-rays in children above 5 years admitted with asthma exacerbation

open access: yesMuller Journal of Medical Sciences and Research, 2018
Context: Asthma is a heterogeneous disease characterized by chronic airway inflammation that causes airway hyperresponsiveness. The diagnosis of asthma is mainly clinical, and chest X-rays are not required for the diagnosis or grading of severity of ...
Sujonitha John   +3 more
doaj   +1 more source

The Structure of Some Crystals as Indicated by Their Diffraction of X-rays

open access: yes, 1913
A new method of investigating the structure of a crystal has been afforded by the work of Laue* and his collaborators on the diffraction of X-rays by crystals.
W. Bragg
semanticscholar   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Raios-x: fascinação, medo e ciência X-rays: fascination, fear and science

open access: yesQuímica Nova, 2009
This work presents the discovery and the use of x-rays at the end of the XIXth and the beginning of the XXth century. X-rays greatly impacted science and everyday life. Their existence broke the idea that knowledge had reached a limiting step. In general,
Rodrigo da Silva Lima   +2 more
doaj   +1 more source

Signatures of X-rays in the early Universe [PDF]

open access: yes, 2012
[abridged] With their long mean free paths and efficient heating of the intergalactic medium (IGM), X-rays could have a dramatic impact on the thermal and ionization history of the Universe.
A. Mesinger, A. Ferrara, D. Spiegel
semanticscholar   +1 more source

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