Results 41 to 50 of about 6,270,911 (362)
X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation.
Annual Review of Genetics, 2018 In somatic nuclei of female therian mammals, the two X chromosomes display very different chromatin states: One X is typically euchromatic and transcriptionally active, and the other is mostly silent and forms a cytologically detectable heterochromatic ...
Rafael Galupa, E. Heard
semanticscholar +1 more source
The human inactive X chromosome modulates expression of the active X chromosome [PDF]
Cell Genomics, 2021 SummaryResearchers have presumed that the “inactive” X chromosome (Xi) has little impact, in trans, on the “active” X (Xa). To test this, we quantified Xi and Xa gene expression in individuals with one Xa and zero to three Xi’s. Our linear modeling revealed modular Xi and Xa transcriptomes and significant Xi-driven expression changes for 38% (162/423 ...
Muenke +22 more
openaire +4 more sources
Global analysis of X-chromosome dosage compensation
Journal of Biology, 2006 Background Drosophila melanogaster females have two X chromosomes and two autosome sets (XX;AA), while males have a single X chromosome and two autosome sets (X;AA).
Malley James D +8 more
doaj +1 more source
Nucleus, 2021 Mammals use X chromosome inactivation to compensate for the sex difference in numbers of X chromosomes. A relatively unexplored question is how the active X is protected from inactivation by its own XIST gene, the long non-coding RNA, which initiates ...
Barbara R. Migeon
doaj +1 more source
X Chromosome Evolution in Cetartiodactyla [PDF]
Genes, 2017 The phenomenon of a remarkable conservation of the X chromosome in eutherian mammals has been first described by Susumu Ohno in 1964. A notable exception is the cetartiodactyl X chromosome, which varies widely in morphology and G-banding pattern between species.
Alexey I. Makunin +15 more
openaire +6 more sources
Escape From X-Chromosome Inactivation: An Evolutionary Perspective
Front. Cell Dev. Biol., 2019 Sex chromosomes originate as a pair of homologus autosomes that then follow a general pattern of divergence. This is evident in mammalian sex chromosomes, which have undergone stepwise recombination suppression events that left footprints of evolutionary
Bronwyn J. Posynick, Carolyn J. Brown
semanticscholar +1 more source
Rlim/Rnf12, Rex1, and X Chromosome Inactivation
Frontiers in Cell and Developmental Biology, 2019 RLIM/Rnf12 is an E3 ubiquitin ligase that has originally been identified as a transcriptional cofactor associated with LIM domain transcription factors.
Feng Wang, Ingolf Bach
doaj +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Elastic dosage compensation by X-chromosome upregulation
Nature Communications, 2022 The concerted dynamics of X-chromosome upregulation and X-chromosome inactivation, which collectively balance X-chromosome expression, are not well understood.
Antonio Lentini +8 more
doaj +1 more source
Sex-biased expression of microRNAs in Drosophila melanogaster [PDF]
Marco A (2014) Open Biology 4, 140024, 2013 Most animals have separate sexes. The differential expression of gene products, in particular that of gene regulators, is underlying sexual dimorphism. Analyses of sex-biased expression have focused mostly in protein coding genes. Several lines of evidence indicate that microRNAs, a class of major gene regulators, are likely to have a significant role ...
arxiv +1 more source