Results 101 to 110 of about 196,851 (322)

Proteogenomic Characterization Reveals Subtype‐Specific Therapeutic Potential for HER2‐Low Breast Cancer

Advanced Science, EarlyView.
Multiomic profiling of HER2‐low breast cancer identifies three proteomic subtypes with distinct therapeutic strategies: endocrine, antiangiogenic, and anti‐HER2 therapies. Genomic and lactate modification landscapes are detailed, providing insights for precise management.
Shouping Xu, Keda Yu, Lei Liu, Qin Wang, Xiaohui Wu, Yihai Chen, Guozheng Li, Xin Zhang, Bo Wei, Zitong Fu, Abiyasi Nanding, Zuxianglan Zhao, Lingbing Yang, Xingda Zhang, Jianyu Wang, Wantong Sun, Yi Hao, Zhongyi Cheng, Xiaojiang Cui, Hao Wu, Da Pang   +20 more
wiley   +1 more source

The Ftx Noncoding Locus Controls X Chromosome Inactivation Independently of Its RNA Products [PDF]

, 2018
Giulia Furlan, Nancy Gutierrez Hernandez, Christophe Huret, Rafael Galupa, Joke G. van Bemmel, Antonio Romito, Édith Heard, Céline Morey, Claire Rougeulle   +8 more
openalex   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

CTCF-mediated insulation and chromatin environment modulate Car5b escape from X inactivation

BMC Biology
Background Genes that escape X-chromosome inactivation (XCI) in female somatic cells vary in number and levels of escape among mammalian species and tissues, potentially contributing to species- and tissue-specific sex differences.
He Fang, Ana R. Tronco, Giancarlo Bonora, Truong Nguyen, Jitendra Thakur, Joel B. Berletch, Galina N. Filippova, Steven Henikoff, Jay Shendure, William S. Noble, Zhijun Duan, Christine M. Disteche, Xinxian Deng   +12 more
doaj   +1 more source

Sex, sex chromosomes and gene expression

BMC Biology, 2011
The X chromosome has fewer testis-specific genes than autosomes in many species. This bias is commonly attributed to X inactivation in spermatogenesis but a recent paper in BMC Biology provides evidence against X inactivation in Drosophila and proposes ...
Wu Chung-I, Lu Xuemei
doaj   +1 more source

Carrier detection in X-linked severe combined immunodeficiency based on patterns of X chromosome inactivation. [PDF]

, 1987
Jennifer M. Puck, Robert L. Nussbaum, Mary Ellen Conley   +2 more
openalex   +1 more source

CircTspan3 Promotes Cartilage Development Through ANNEXIN A2‐Mediated Ferroptosis and Apoptosis Inhibition and Exosome‐Mediated Paracrine Signaling

Advanced Science, EarlyView.
This study reveals that XBP1s drives production of circTspan3, a circular RNA that strengthens cartilage by boosting anabolic activity and limiting cell death. Phosphorylated ANXA2 directs circTspan3 into exosomes, enabling paracrine repair. Exosomal circTspan3 expands growth‐plate cartilage and promotes in vivo regeneration, highlighting its promise ...
Yiming Pan, Fengmei Zhang, Jiayan Zhong, Qian Gong, Nana Geng, Biao Kuang, Qiumei Lan, Miao Yi, Qiqi Zeng, Cheng Chen, Mengtian Fan, Chunliang Zhao, Deping Zeng, Yu Du, Mao Nie, Zhibiao Wang, Fengjin Guo   +16 more
wiley   +1 more source

Implication of the Mediator kinase module in CIZ1 recruitment and gene silencing by Xist during the initiation of X inactivation

Epigenetics Reports
In mammals, dosage compensation between the sexes is mediated by X chromosome inactivation. The long non-coding Xist RNA initiates this process. The molecular mechanism of X-linked gene silencing is beginning to be understood. We have previously reported
Jingyi Chen, Kevin Halter, Timothe Weitzel, Anton Wutz   +3 more
doaj   +1 more source

Gene trap as a tool for genome annotation and analysis of X chromosome inactivation in human embryonic stem cells [PDF]

, 2004
S. K. Dhara
openalex   +1 more source

Population‐Based Multi‐Omics and Cohort Study Identifying Predictive Biomarkers and Therapeutic Targets for Psoriatic Disease

Advanced Science, EarlyView.
Psoriatic disease (PsD) is a chronic skin disease, with challenges in early risk stratification and drug development. Through gene‐level causal inference framework and expression level validation, combined with longitudinal cohort study, CDSN and PRSS8 have been identified as candidate biomarkers and therapeutic targets for PsD.
Tianxing Wu, Jialiang Luo, Haoyuan Qiu, Weijie Shao, Yueyang Lu, Meixuan Luo, Zhaofeng Lin, Yan Zhang, Libo Zhang, Hong Wang, Jia Zhou, Guangfeng Ruan, Peihua Cao, Daming Zuo   +13 more
wiley   +1 more source