Results 131 to 140 of about 196,851 (322)

Mechanisms of Aristolochic Acid Resistance in Specialist Butterflies and Evolutionary Insights for Potential Protective Pathways

Advanced Science, EarlyView.
The study provides an extreme example of insect adaptation to highly toxic defenses of host plants, and investigates the complex strategies to resist carcinogenic aristolochic acids, including physical isolation, metabolic detoxification, and DNA repair.
Yang Luan, Yubo Zhang, Jingjing Li, Jianqing Zhu, Yuyang Lei, Yushi Hu, Zhenqiang Xin, Tianpei Xie, Jiang Zheng, Yuanyuan Lin, Jingjing Shen, Yiyi Cao, Xinyue You, Jing Xi, Jiaying Wu, Weiying Liu, Xinyu Zhang, Yuanting Zheng, David J. Lohman, Leming Shi, Wei Zhang   +20 more
wiley   +1 more source

Is human X chromosome inactivation a sex-determining device?

, 1985
H. Sharat Chandra
openalex   +2 more sources

Revisiting the function of nuclear scaffold/matrix binding proteins in X chromosome inactivation [PDF]

, 2011
Yūko Hasegawa, Shinichi Nakagawa
openalex   +1 more source

The human inactive X chromosome modulates expression of the active X chromosome [PDF]

, 2021
Adrianna K. San Roman, Alexander K. Godfrey, Helen Skaletsky, Daniel W. Bellott, Abigail F. Groff, Hannah L. Harris, Laura V. Blanton, Jennifer F. Hughes, Laura G. Brown, Sidaly Phou, Ashley Buscetta, Paul Kruszka, Nicole Banks, Amalia Dutra, Evgenia Pak, Patricia C. Lasutschinkow, Colleen Keen, Shanlee Davis, Nicole Tartaglia, Carole Samango‐Sprouse, Maximilian Muenke, David C. Page   +21 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Awakening the sleeping giant: methods for reactivating the inactive X chromosome as clinical treatment for X-linked disorders

, 2018
Andrea Cerase
openalex   +2 more sources

A rapid passage through a two-active-X-chromosome state accompanies the switch of imprinted X-inactivation patterns in mouse trophoblast stem cells [PDF]

, 2015
Julie Prudhomme, Agnès Dubois, Pablo Navarro, Danielle Arnaud, Philip Avner, Céline Morey   +5 more
openalex   +1 more source

The Implication of Early Chromatin Changes in X Chromosome Inactivation

Cell, 2019
J. J. Żylicz, Aurélie Bousard, Kristina Žumer, François Dossin, Eusra Mohammad, S. T. da Rocha, B. Schwalb, L. Syx, F. Dingli, D. Loew, P. Cramer, E. Heard   +11 more
semanticscholar   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Single Cell Expression Data Reveal Human Genes that Escape X-Chromosome Inactivation [PDF]

, 2016
Kerem Wainer-Katsir, Michal Linial
openalex   +1 more source