Results 171 to 180 of about 196,851 (322)

Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing (IWGT)

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Exposure levels without appreciable human health risk may be determined by dividing a point of departure on a dose–response curve (e.g., benchmark dose) by a composite adjustment factor (AF). An “effect severity” AF (ESAF) is employed in some regulatory contexts.
Barbara L. Parsons, Marc A. Beal, Kerry L. Dearfield, George R. Douglas, Min Gi, B. Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Michelle Kenyon, Alexandra S. Long, David P. Lovell, Anthony M. Lynch, Meagan B. Myers, Stefan Pfuhler, Alisa Vespa, Andreas Zeller, George E. Johnson, Paul A. White   +17 more
wiley   +1 more source

Clinical relevant Bruton's X-linked tyrosine kinase deficiency in a female with extreme X-chromosome inactivation. [PDF]

Allergy Asthma Clin Immunol
NoorSaeed SM, Alrafiaah AS, Alghamdi M, Shapiro AJ, McCusker C.   +4 more
europepmc   +1 more source

Strong evidence that skewed X-chromosome inactivation is not associated with recurrent pregnancy loss: an incident paired case control study [PDF]

, 2007
Élisabeth Pasquier, Caroline Bohec, Luc de Saint Martin, Cédric Le Maréchal, M.T. Le Martelot, Sylvie Roche, Yves Laurent, Claude Férec, M Collet, Dominique Mottier   +9 more
openalex   +1 more source

Affective Dimensions in Maternal Voice During Child Feeding in Mothers With and Without Eating Disorder History—Findings From a Machine Learning Analysis of Speech Data

European Eating Disorders Review, EarlyView.
ABSTRACT Objective Eating disorder (ED) history may impact mother‐child communication during mealtimes and contribute to transgenerational transmission of ED. This study employed machine learning (ML) to identify speech characteristics during mother‐child feeding interactions, aiming for investigating whether vocalised affective characteristics differ ...
Jana Katharina Throm, Manuel Milling, Andreas Triantafyllopoulos, Alexander Kathan, Annica Franziska Dörsam, Johanna Löchner, Björn Schuller, Katrin Elisabeth Giel   +7 more
wiley   +1 more source

Escape From X Chromosome Inactivation as a Driver of Plasmacytoid DC Heterogeneity in Health and Disease. [PDF]

Immunol Rev
Barrat FJ, Guéry JC.
europepmc   +1 more source

Out of the Silence: Insights into How Genes Escape X-Chromosome Inactivation. [PDF]

Epigenomes, 2023
Peeters SB, Posynick BJ, Brown CJ.
europepmc   +1 more source

Loss of the Y Chromosome in Oral Potentially Premalignant Disorders Predicts Malignant Progression: An Integrative Cross‐Species Multi‐Cohort Bioinformatic Study

Head &Neck, EarlyView.
ABSTRACT Background The loss of the Y chromosome (LOY) and the extreme down‐regulation of Y chromosome gene expression (EDY) are frequently observed in oral squamous cell carcinoma (OSCC). However, their roles in oral potentially malignant disorders (OPMDs) are unclear.
Rui Han, Jos B. Poell, Cristina Conde‐Lopez, Tuula Salo, Ina Kurth, Ruud H. Brakenhoff, Jochen Hess   +6 more
wiley   +1 more source

Evaluation of tumor clonality with chemical carcinogenesis in a mouse model of visualized X chromosome inactivation. [PDF]

J Toxicol Pathol
Maeda-Tateishi T, Nagata Y, Imanishi Y, Hirakawa T, Tan SS, Emoto M, Gi M.   +6 more
europepmc   +1 more source

Modeling X-chromosome inactivation and reactivation during human development. [PDF]

Curr Opin Genet Dev, 2023
Khan SA, Theunissen TW.
europepmc   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source