Results 191 to 200 of about 317,261 (329)

X chromosome inactivation in mammals: general principles and species-specific considerations. [PDF]

EMBO Rep
Alfeghaly C, Rougeulle C.
europepmc   +1 more source

Modeling X-chromosome inactivation and reactivation during human development. [PDF]

Curr Opin Genet Dev, 2023
Khan SA, Theunissen TW.
europepmc   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation. [PDF]

PLoS Genet
Monfort A, Di Minin G, Sting S, Dumeau CE, Scambler P, Wutz A.   +5 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Defective X-chromosome inactivation and cancer risk in women. [PDF]

Commun Biol
Cáceres A, Pérez-Jurado LA, Alegret-García A, Dwaraka VB, Smith R, González JR.   +5 more
europepmc   +1 more source

Inactivation du chromosome X [PDF]

médecine/sciences, 2008
Sandrine Augui, Edith Heard
openaire   +1 more source

Beyond Tradition: An Integrated Toxicological, Ecological, and Public Health Perspective on Aristolochic Acids

Journal of Applied Toxicology, EarlyView.
ABSTRACT Aristolochia species have long been used in traditional medicine for their presumed anti‐inflammatory, analgesic and antimicrobial properties. However, extensive toxicological and epidemiological evidence now demonstrates that these plants contain aristolochic acids (AAs) I and II, highly potent nephrotoxic, genotoxic, and carcinogenic ...
Victor Ventura de Souza, Lara Rodrigues De Andrade, Tatiana da Silva Souza   +2 more
wiley   +1 more source

FemXpress: Systematic Analysis of X Chromosome Inactivation Heterogeneity in Female Single-Cell RNA-Seq Samples. [PDF]

Adv Sci (Weinh)
Wang X, Ma Y, Li F, Cui W, Pan T, Wang S, Ma S, Shan Q, Liu C, Wang Y, Zhang Y, Zhou Y, Li W, Wang P, Zhou Q, Feng G.   +15 more
europepmc   +1 more source

The long noncoding RNA, Jpx, is a molecular switch for X chromosome inactivation.

Cell, 2010
D. Tian, Shan Sun, Jeannie T. Lee
semanticscholar   +1 more source