Results 281 to 290 of about 196,851 (322)
Some of the next articles are maybe not open access.
Digging into X chromosome inactivation
Science, 2021Characterizing X chromosome inactivation in nonhuman primates reveals some ...
Rougeulle, C., Heard, Edith
openaire +3 more sources
Nonrandom X Chromosome Inactivation Detection
Current Protocols, 2023AbstractX chromosome inactivation patterns may be clinically useful in assessing tumor clonality, determining carrier status for certain X‐linked disorders, and evaluating the pathogenicity of a genetic variant identified in an X‐linked gene. The protocols in this article utilize the highly polymorphic trinucleotide repeat within the first exon of the ...
openaire +2 more sources
1985
Female mammals have two X-chromosomes, but male mammals have only one X-chromosome. This could result in females having twice as many X-chromosome transcripts as males, but this does not occur because one of the X-chromosomes is largely inactive. (The tip of the short arm of both X-chromosomes is active.) The inactive X-chromosome is highly condensed ...
Roger L. P. Adams, Roy H. Burdon
openaire +1 more source
Female mammals have two X-chromosomes, but male mammals have only one X-chromosome. This could result in females having twice as many X-chromosome transcripts as males, but this does not occur because one of the X-chromosomes is largely inactive. (The tip of the short arm of both X-chromosomes is active.) The inactive X-chromosome is highly condensed ...
Roger L. P. Adams, Roy H. Burdon
openaire +1 more source
Assessing Skewed X‐Chromosome Inactivation
Current Protocols in Human Genetics, 2018AbstractWe describe a simple and straightforward method for detection and characterization of X‐chromosome inactivation in females and/or individuals with more than one X chromosome. The X‐chromosome inactivation pattern is visualized on a single‐cell level using 5‐ethynyl‐2‐deoxyuridine (EdU) instead of the previously widely applied 5‐bromo‐2 ...
Thomas, Liehr +3 more
openaire +2 more sources
X-CHROMOSOME INACTIVATION IN MAMMALS
Annual Review of Genetics, 1997▪ Abstract The inactive X chromosome differs from the active X in a number of ways; some of these, such as allocyclic replication and altered histone acetylation, are associated with all types of epigenetic silencing, whereas others, such as DNA methylation, are of more restricted use. These features are acquired progressively by the inactive X after
E, Heard, P, Clerc, P, Avner
openaire +2 more sources
Mechanisms of X-chromosome inactivation
Frontiers in Bioscience, 2006Mammalian X-chromosome inactivation is an impressive example of epigenetic gene regulation, whereby the majority of genes on the approximately 160 Mb X chromosome are silenced in a strictly cis-limited fashion. In this review we will discuss the important players involved in the silencing process.
Samuel C, Chang +3 more
openaire +2 more sources
1999
We have known for the greater part of the 20th century that mammalian females and males differ in both number and kind of sex chromosomes. While females have two X-chromosomes (XX), males have one X- and one Y-chromosome (XY). Both the X and Y carry genes that enhance female and male reproductive function, respectively.
openaire +1 more source
We have known for the greater part of the 20th century that mammalian females and males differ in both number and kind of sex chromosomes. While females have two X-chromosomes (XX), males have one X- and one Y-chromosome (XY). Both the X and Y carry genes that enhance female and male reproductive function, respectively.
openaire +1 more source
Gene regulation in time and space during X-chromosome inactivation
Nature reviews. Molecular cell biology, 2022Agnese Loda, Samuel Collombet, E. Heard
semanticscholar +1 more source
Inactivation of the X-Chromosome
New England Journal of Medicine, 1972IN its classic form, the hypothesis of X-chromosome inactivation holds that only one of the two X-chromosomes present in cells of female mammals is functional. The "decision" of which X-chromosome is to operate in a cell occurs quite early in embryogenesis and, once made, is irreversible for that cell and all its progeny.
openaire +2 more sources
Xist and X chromosome inactivation
Molecular and Cellular Endocrinology, 1998X inactivation acts in female mammals to equalise X-linked gene dosage between XX females and XY males. X inactivation is controlled by a single X-linked cis-acting locus called the X inactivation centre (Xic). In 1991 the Xist gene was identified as a candidate for the Xic. Xist is expressed in all adult female tissues, but only from the allele on the
openaire +2 more sources