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X chromosome inactivation: A hypothesis
BioEssays, 1988AbstractX‐chromosome inactivation refers to the coordinate regulation of almost all genes on the mammalian × chromosome. Most models for × chromosome inactivation suppose a role for methylation of × chromosome DNA sequences and/or the heterochromatinization of large «domains» of the × chromosome containing many genes.1 Some recent work concerning the ...
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X-chromosome inactivation in mammals
Cell, 1982+ y2a). The immune response to trinitrophenol-Ficoll, a T-cell-independent type II antigen, has been analyzed at the B-cell level (Mongini et al., JEM 755, 884-902, 1982). Following hyperimmunization with trinitrophenol-Ficoll, B-cell clones were isolated by the splenic focus technique in irradiated nude mouse recipients. All B-cell clones expressed mu,
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Nonrandom X Chromosome Inactivation Detection
Current Protocols in Human Genetics, 2014AbstractX chromosome inactivation patterns may be clinically useful in assessing tumor clonality, determining carrier status for certain X‐linked disorders and evaluating the pathogenicity of a genetic variant identified in an X‐linked gene. The protocols in this unit utilize the highly polymorphic trinucleotide repeat within the first exon of the ...
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X Chromosome Inactivation and Autoimmunity
Clinical Reviews in Allergy & Immunology, 2009Autoimmune diseases appear to have multiple contributing factors including genetics, epigenetics, environmental factors, and aging. The predominance of females among patients with autoimmune diseases suggests possible involvement of the X chromosome and X chromosome inactivation.
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Imprinting and X-Chromosome Inactivation
1999In normal female mammals one of the two X-chromosomes in every somatic cell is inactive i.e. it fails to transcribe RNA (reviews Gartler et al. 1992; Migeon 1994; Lyon 1996). The result of this is that chromosomally XX females and XY males both effectively have a single dosage of the products of X-linked genes.
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Requirement for Xist in X chromosome inactivation
Nature, 1996Graeme D. Penny +4 more
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MAMMALIAN X-CHROMOSOME INACTIVATION
Annual Review of Genetics, 1983S M, Gartler, A D, Riggs
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Xg AND X CHROMOSOME INACTIVATION
The Lancet, 1971J, Ducos, Y, Marty, R, Sanger, R R, Race
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