Results 171 to 180 of about 42,906 (302)

Genetic Determinants of Hematopoietic Toxicity Risk in Thai Pediatric Patients Undergoing 6‐Mercaptopurine Treatment

Clinical and Translational Science, Volume 19, Issue 2, February 2026.
ABSTRACT The nucleoside diphosphate‐linked moiety X‐type motif 15 (NUDT15) has been identified as a key genetic determinant of 6‐mercaptopurine (6‐MP)‐induced hematopoietic toxicity in populations with a high frequency of NUDT15 variants but a low frequency of thiopurine S‐methyltransferase (TPMT) variants.
Kanyarat Khaeso, Su‐on Chainansamit, Pitchayanan Kuwatjanakul, Patcharee Komvilaisak, Nontaya Nakkam, Kunanya Suwannaying, Suda Vannaprasaht, Areerat Dornsena, Wichittra Tassaneeyakul   +8 more
wiley   +1 more source

Trends in initial pharmacological COPD treatment in primary care (2010-2021): a population-based study using the PHARMO Data Network. [PDF]

Respir Res
Rodrigues G, Antão J, Deng Q, Baak BN, Marques A, Franssen FME, Spruit MA.   +6 more
europepmc   +1 more source

NICE asthma guidelines: time to re-evaluate the diagnostic value of exercise challenge testing? [PDF]

ERJ Open Res, 2023
Simpson AJ, Price OJ.
europepmc   +1 more source

Relation of Plasma Level of Hypoxanthine/Xanthine as Markers of Oxidative Stress: Relation With Different Stages of Obstructive Sleep Apnea Syndrome [PDF]

, 2015
Harmanjit Hira
openalex   +1 more source

The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8‐substituted xanthines

British Journal of Pharmacology, 1990
A. Sebastião, Trevor W. Stone, J. A. Ribeiro   +2 more
semanticscholar   +1 more source

Untersuchungen zum Ursprung der Substratspezifität von Enzymen der Amidohydrolase‐Superfamilie

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Umfassende Analysen zweier Enzymklassen aus der Amidohydrolase‐Superfamilie (AHS) ergaben, dass die Katalyse über eine 1,4‐ bzw. 1,6‐nukleophile konjugierte Addition abläuft und diese Eigenschaft die Substratspezifität bestimmt. Obwohl alle Substrate und Produkte vollständig achiral sind, führt dieser mechanistische Unterschied zu einer invertierten ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Fixation of xanthine prototropic tautomers by methyl group does not practically change their relative energy: a DFT quantum-chemical investigation [PDF]

, 2003
Maxim O. Platonov, S. P. Samijlenko, Dmytro М. Hovorun   +2 more
openalex   +1 more source

On the Origin of Substrate Specificity of Enzymes from the Amidohydrolase Superfamily

Angewandte Chemie International Edition, Volume 65, Issue 4, 22 January 2026.
Comprehensive analyses of two enzyme classes from the amidohydrolase superfamily (AHS) revealed that catalysis proceeds either via 1,4 or 1,6 nucleophilic conjugate addition and that this property defines substrate specificity. Moreover, although all substrates and products are entirely achiral, this mechanistic difference results in an inverted ...
Lukas Drexler, Torben F. Fürtges, Till Rudack, Reinhard Sterner   +3 more
wiley   +1 more source

Faecal Metabolome Profiles in Individuals Diagnosed with Hyperplastic Polyps and Conventional Adenomas. [PDF]

Int J Mol Sci
Valdés A, Ruiz-Saavedra S, Salazar N, Cifuentes A, Suárez A, Díaz Y, Del Rey CG, González S, de Los Reyes-Gavilán CG.   +8 more
europepmc   +1 more source

Simultaneous liquid chromatography of 5-fluorouracil, uridine, hypoxanthine, xanthine, uric acid, allopurinol, and oxipurinol in plasma. [PDF]

, 1980
W E Wung, Stephen B. Howell
openalex   +1 more source