Results 311 to 320 of about 44,980 (368)

Xanthine urolithiasis

Urology, 2006
Xanthine calculi are uncommonly encountered stones. When they occur, they typically do so in association with inborn metabolic disorders such as hereditary xanthinuria or Lesch-Nyhan syndrome. They may also occur in association with states of profound hyperuricemia such as myeloproliferative disease after treatment with allopurinol.
Vernon M, Pais, Gregory, Lowe, Costas D, Lallas, Glenn M, Preminger, Dean G, Assimos   +4 more
openaire   +2 more sources

Self-assembly of N3-substituted xanthines in the solid state and at the solid-liquid interface.

Langmuir, 2013
The self-assembly of small molecular modules interacting through noncovalent forces is increasingly being used to generate functional structures and materials for electronic, catalytic, and biomedical applications.
A. Ciesielski, Sébastien Haar, A. Bényei, G. Paragi, C. F. Guerra, F. Bickelhaupt, F. Bickelhaupt, S. Masiero, J. Szolomajer, P. Samorí, G. Spada, L. Kovács   +11 more
semanticscholar   +1 more source

Xanthine oxidase and xanthine dehydrogenase

The FASEB Journal, 1995
Xanthine oxidase and xanthine dehydrogenase are enzymes involved in the metabolism of purines and pyrimidines in various organisms. Their relationship to one another has been the subject of considerable debate, primarily because of their proposed roles in ischemia/reperfusion damage in tissues.
Takeshi Nishino, Russ Hille
openaire   +3 more sources

Novel 1,3-dipropyl-8-(3-benzimidazol-2-yl-methoxy-1-methylpyrazol-5-yl)xanthines as potent and selective A₂B adenosine receptor antagonists.

Journal of Medicinal Chemistry, 2012
Molecular modeling studies, including the comparative molecular field analysis (CoMFA) method, on 52 antagonists of the A(2B) adenosine receptor with known biological activity were performed to identify the three-dimensional features responsible for A(2B)
P. Baraldi, S. Baraldi, G. Saponaro, D. Preti, R. Romagnoli, L. Piccagli, A. Cavalli, M. Recanatini, A. Moorman, A. Zaid, K. Varani, P. Borea, M. Tabrizi   +12 more
semanticscholar   +1 more source

Regulation of xanthine dehydrogenase and xanthine oxidase activity by hypoxia

American Journal of Physiology-Lung Cellular and Molecular Physiology, 1996
The present study determined the effect of hypoxia on xanthine dehydrogenase (XDH) and xanthine oxidase (XO) activity and gene and protein expression in cultured bovine aortic endothelial cells (BAEC). BAEC were exposed to hypoxia (3% O2) or anoxia (0% O2) for 24 or 48 h and to 24 h of hypoxia followed by 24 h of reoxygenation.
T. P. Huecksteadt, W. B. Poss, P. C. Panus, John R. Hoidal, B. A. Freeman   +4 more
openaire   +3 more sources

3-Substituted xanthines as promising candidates for quadruplex formation: Computational, synthetic and analytical studies

, 2011
Our computational studies suggest that 3-substituted xanthines are good candidates for tetrad and quadruplex structures. 3-Methylxanthine (3MX) has been synthesized from 7-benzylxanthine, and the existence of tetrameric and octameric aggregates of 3MX ...
J. Szolomajer, G. Paragi, G. Batta, C. F. Guerra, F. Bickelhaupt, Z. Kele, P. Pádár, Z. Kupihar, L. Kovács   +8 more
semanticscholar   +1 more source

Development of new fluorescent xanthines as kinase inhibitors.

Organic Letters, 2010
An efficient and versatile synthetic approach for the preparation of highly substituted xanthine derivatives has been developed by a combination of direct N7- and C8-arylation.
Donghee Kim, H. Jun, Hyunseung Lee, Soon-Sun Hong, Sungwoo Hong   +4 more
semanticscholar   +1 more source

Ischaemic Brain Oedema and Xanthine-Xanthine Oxidase System

1990
The formation of oxygen-derived free radicals in cerebral ischaemia has been implicated in altering the BBB permeability, cause oedema and tissue damage. However little attention has been paid regarding the involvement of xanthine oxidase in the cerebral ischaemic events.
Masatsune Ishikawa, Haruhiko Kikuchi, Kinuta Y   +2 more
openaire   +2 more sources

8-cyclopentyl-1,3-dipropylxanthine and other xanthines differentially bind to the wild-type and delta F508 first nucleotide binding fold (NBF-1) domains of the cystic fibrosis transmembrane conductance regulator.

Biochemistry, 1997
Cystic fibrosis is an autosomal recessive disorder affecting chloride transport in pancreas, lung, and other tissues, which is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR).
Cohen Be, George Lee, Kenneth A Jacobson, Kim Yc, Zhen Huang, Sorscher Ej, Harvey B. Pollard   +6 more
semanticscholar   +1 more source

Synthesis of paraxanthine analogs (1,7-disubstituted xanthines) and other xanthines unsubstituted at the 3-position: structure-activity relationships at adenosine receptors.

Journal of Medicinal Chemistry, 1993
Synthetic procedures for the preparation of various 3-unsubstituted xanthines, including paraxanthine analogs (1,7-disubstituted xanthines) and 1,8-disubstituted xanthines, were developed.
C. Müller, D. Shi, Malcolm Manning, J. Daly   +3 more
semanticscholar   +1 more source