Results 31 to 40 of about 766 (123)

Xanthine oxidase activity in thiopurine curative Chinese inflammatory bowel disease patients

Pharmacology Research &Perspectives, Volume 9, Issue 3, June 2021., 2021
Xanthine oxidase (XO) competes with thiopurine S‐methyltransferase (TPMT) and hypoxanthine guanine phosphoribosyltransferase (HPRT) to metabolize azathioprine (AZA)/6‐mercaptopurine (6‐MP) in vivo. A retrospective investigation was performed to detect the activity of XO in thiopurine curative Chinese inflammatory bowel disease (IBD) patients.
Liang Ding, Fang‐bin Zhang, Hui Liu, Xiang Gao, Hui‐chang Bi, Ling Huang, Xue‐ding Wang, Bai‐li Chen, Yu Zhang, Chuanzhu Lv, Pin‐jin Hu, Min Huang   +11 more
wiley   +1 more source

Urolithiasis in dogs: Evaluation of trends in urolith composition and risk factors (2006‐2018)

Journal of Veterinary Internal Medicine, Volume 35, Issue 3, Page 1406-1415, May/June 2021., 2021
Abstract Background Urolithiasis is a common and often recurrent problem in dogs. Objective To evaluate trends in urolith composition in dogs and to assess risk factors for urolithiasis, including age, breed, sex, neuter status, urolith location, and bacterial urolith cultures.
Lucy Kopecny, Carrie A. Palm, Gilad Segev, Jodi L. Westropp   +3 more
wiley   +1 more source

Oxidative Stress Genes in Diabetes Mellitus Type 2: Association with Diabetic Kidney Disease

Oxidative Medicine and Cellular Longevity, Volume 2021, Issue 1, 2021., 2021
Diabetic type 2 patients compared to nondiabetic patients exhibit an increased risk of developing diabetic kidney disease (DKD), the leading cause of end‐stage renal disease. Hyperglycemia, hypertension, oxidative stress (OS), and genetic background are some of the mechanisms and pathways implicated in DKD pathogenesis.
Athanasios Roumeliotis, Stefanos Roumeliotis, Fotis Tsetsos, Marianthi Georgitsi, Panagiotis I. Georgianos, Aikaterini Stamou, Anna Vasilakou, Kalliopi Kotsa, Xanthippi Tsekmekidou, Peristera Paschou, Stylianos Panagoutsos, Vassilios Liakopoulos, Elena Azzini   +12 more
wiley   +1 more source

A frameshift mutation in MOCOS is associated with familial renal syndrome (xanthinuria) in Tyrolean Grey cattle [PDF]

, 2016
Background Renal syndromes are occasionally reported in domestic animals. Two identical twin Tyrolean Grey calves exhibited weight loss, skeletal abnormalities and delayed development associated with kidney abnormalities and formation of uroliths ...
Piffer, Christian, Murgiano, Leonardo, Inmaculada Diez-Prieto (3521027), Cord DrĂśgemĂźller (3428597), Diez Prieto, Inmaculada, Leonardo Murgiano (492751), Christian Piffer (551864), Diez-Prieto, Inmaculada, Bolcato, Marilena, Gentile, Arcangelo, Jagannathan, Vidhya, Drögemüller, Cord, Vidhya Jagannathan (13914), Arcangelo Gentile (132262), Marilena Bolcato (551861), Bolcato M, Jagannathan V, Drögemüller C, Piffer C, Gentile A, Bolcato, Marinela, Diez-Prieto I, Murgiano L   +22 more
core   +5 more sources

A prevalent MOCS2 variant in the Roma population is associated with a novel mild form of molybdenum cofactor deficiency. [PDF]

Eur J Pediatr
Xanthinurias are rare inherited disorders of purine metabolism. Xanthinuria type III is caused by molybdenum cofactor deficiency (MoCD) due to pathogenic variants in MOCS1, MOCS2, MOCS3, or GEPH genes.
Cho SK, Schwarz G, Tasic V, Křížková M, Krijt J, Roeper J, Honzík T, Šebesta I, Kožich V, Šaligová J, Pavelcova K, Masinova J, Winkler CA, Stiburkova B.   +13 more
europepmc   +2 more sources

Deletion of Mocos Induces Xanthinuria with Obstructive Nephropathy and Major Metabolic Disorders in Mice

, 2021
International audienceBackground : Xanthinuria type II is a rare autosomal purine disorder. This recessive defect of purine metabolism remains an underrecognized disorder.
Pailloux, Julie, Erard, Nicolas, Valerie F.J. Quesniaux, Rontani, Pauline, Patrick Emond, Michael J. Mihatsch, Foucher, Frédéric, Sedda, Delphine, Delphine Sedda, Sylvie Mavel, Bernhard Ryffel, Frederic Foucher, Mackowiak, Claire, Antoine Lefevre, Elodie Culerier, Quesniaux, Valérie, Ryffel, Bernhard, Dudas, Ana, Erard-Garcia, Madeleine, Culerier, Elodie, Madeleine Erard-Garcia, Julie Pailloux, Pauline Rontani, Marc Le Bert, Le Bert, M, Claire Mackowiak, Nicolas Erard, Ana Dudas, Emond, Patrick, Lefevre, Antoine, Mihatsch, Michael, J, Mavel, Sylvie   +31 more
core   +1 more source

Rare forms of nephrolithiasis

Pediatria i Medycyna Rodzinna, 2019
Inborn errors of metabolism that may lead to calculus formation within the urinary tract include: adenine phosphoribosyltransferase deficiency, xanthine oxidase deficiency, orotic aciduria (acidosis) type I and alkaptonuria.
Piotr Skrzypczyk, Małgorzata Pańczyk-Tomaszewska   +1 more
doaj   +1 more source

Xanthinuria in a family of Cavalier King Charles spaniels

, 1997
Xanthine calculi mere found in a 7-month-old male Cavalier King Charles spaniel with urethral obstruction and renal insufficiency, Because the only two other reported cases of naturally occurring xanthine urolithiasis concerned a Cavalier King Charles ...
Nickel, RF, vanZuilen, CD, Reijngoud, DJ; id_orcid, vanDijk, TH   +3 more
core   +2 more sources

Leishmaniosis caused by Leishmania infantum in ferrets: Update review

Veterinary and Animal Science, 2022
Leishmaniosis in domestic ferrets (Mustela putorius furo) is a disease caused by Leishmania infantum, a parasite transmitted through the bite of an infected female phlebotomine sand fly. Among vertebrates, the dog is the primary domestic reservoir of the
Sergio Villanueva-Saz, Jacobo Giner, Diana Marteles, Maite Verde, Andrés Yzuel, Cristina Riera, Roser Fisa, Magdalena Alcover, Antonio Fernández   +8 more
doaj   +1 more source

Differential regulation of hypoxanthine and xanthine by obesity in a general population

Journal of Diabetes Investigation, Volume 11, Issue 4, Page 878-887, July 2020., 2020
In the present study, we investigated the associations of obesity with hypoxanthine, xanthine and plasma xanthine oxidoreductase activity in 484 participants from the general population. The concentration of hypoxanthine was independently associated with body mass index and smoking habit, whereas the level of xanthine was associated with parameters of ...
Masato Furuhashi, Masayuki Koyama, Yukimura Higashiura, Takayo Murase, Takashi Nakamura, Megumi Matsumoto, Akiko Sakai, Hirofumi Ohnishi, Marenao Tanaka, Shigeyuki Saitoh, Norihito Moniwa, Kazuaki Shimamoto, Tetsuji Miura   +12 more
wiley   +1 more source