Results 181 to 190 of about 5,171 (202)
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Xanthohumols, diacylglycerol acyltransferase inhibitors, from Humulus lupulus
Phytochemistry, 1997A methanol extract of hops of Humulus lupulus (L.) showed inhibitory activity against rat liver diacylglycerol acyltransferase (DGAT). From DGAT inhibitory activity-guided fractionation, two chalcones were isolated. One was identified as xanthohumol and the other was found to be a new product designated xanthohumol B. The structure of xanthohumol B was
N, Tabata, M, Ito, H, Tomoda, S, Omura
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Anticoccidial Effects of Xanthohumol
Avian Diseases Digest, 2007Xanthohumol (XN), a prenylated chalcone from the hops flower, was examined for its ability to reduce invasion of Madin-Darby bovine kidney (MDBK) cells by Eimeria tenella sporozoites (SZ), as well as to reduce invasion by E. tenella and E. acervulina SZ in the chick host.
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Microbial Metabolism of the Prenylated Chalcone Xanthohumol
Journal of Natural Products, 2006Microbial metabolism of xanthohumol (1), a prenylated chalcone isolated from hops, gave three novel glucosylated derivatives (2-4) and a known compound, isoxanthohumol (5). The structures of the new compounds were identified as xanthohumol 4'-O-beta-glucopyranoside (2), xanthohumol 4,4'-O-beta-diglucopyranoside (3), and 5-methoxy-8-prenylnaringenin 7-O-
Hyun Jung, Kim, Ik-Soo, Lee
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Xanthohumol: A Metabolite with Promising Anti-Neoplastic Potential
Anti-Cancer Agents in Medicinal Chemistry, 2022Abstract: The overwhelming globalburden of cancer has posed numerous challenges and opportunities for developing anti-cancer therapies. Phytochemicalshave emerged as promising synergistic compounds with potential anti-cancer effects to supplement chemo- and immune-therapeutic regimens.
Hardeep S. Tuli +9 more
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Xanthohumol from Hop: Hope for cancer prevention and treatment
IUBMB Life, 2021AbstractCancer is a major public health concern due to high mortality and poor quality of life of patients. Despite the availability of advanced therapeutic interventions, most treatment modalities are not efficacious, very expensive, and cause several adverse side effects.
Sosmitha Girisa +8 more
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Inhibition of Suicidal Erythrocyte Death by Xanthohumol
Journal of Agricultural and Food Chemistry, 2009Xanthohumol is a proapoptotic hop-derived beer component with anticancer and antimicrobial activities. Similar to nucleated cells, erythrocytes may undergo suicidal cell death or eryptosis, which is triggered by oxidative stress (tert-butylhydroperoxide, TBOOH) or energy depletion (removal of glucose).
Syed M, Qadri +3 more
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Triggering of dendritic cell apoptosis by xanthohumol
Molecular Nutrition & Food Research, 2010AbstractXanthohumol, a flavonoid from beer with anticancer activity is known to trigger apoptosis in a variety of tumor cells. Xanthohumol further has anti‐inflammatory activity. However, little is known about the effect of xanthohumol on survival and function of immune cells.
Xuan, Nguyen Thi +5 more
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Enrichment of xanthohumol in the brewing process
Molecular Nutrition & Food Research, 2005Xanthohumol (XN), a component of hops, is lost in significant quantities in the conventional brewing process. In commercial beers less than 0.2 mg XN/L are found. In order to increase the yield of XN in the brewing process, the parameters of XN recovery were studied. During wort boiling, XN is largely isomerised to isoxanthohumol.
Sascha, Wunderlich +2 more
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Biosynthetic14C-labelling of xanthohumol in hop cones
Molecular Nutrition & Food Research, 2005Xanthohumol (Xn) has well-established chemopreventive potential in vitro. In order to carry out in vivo bioavailability and tissue distribution studies,( 14)C-labelled Xn was produced by biolabelling. Supplying hop sprouts with 5 mCi [U-(14)C]glucose led to incorporation of (14)C into Xn. Delivering the radioactive precursor at once resulted in Xn with
Stefanie, Berwanger +3 more
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Re-evaluation of superoxide scavenging capacity of xanthohumol
Free Radical Research, 2010The chemopreventive chalcone xanthohumol (Xh) has been reported to decrease xanthine oxidase (XOD) catalysed formation of formazan from nitroblue tetrazolium (NBT) and is discussed as a potent scavenger of superoxide. Re-evaluation of the scavenging capacity indicated that Xh disturbed detection of superoxide with NBT, in case of an insufficient NBT/Xh
Harald, Schempp +3 more
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