Results 51 to 60 of about 5,171 (202)
Frontiers in Pharmacology, 2023 Severe acute pancreatitis (SAP) is a lethal gastrointestinal disorder, yet no specific and effective treatment is available. Its pathogenesis involves inflammatory cascade, oxidative stress, and autophagy dysfunction.
Yaru Huangfu +13 more
doaj +1 more source
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +3 more sources
Frontiers in Pharmacology, 2021 Osteoarthritis (OA) is the most frequent and disabling disease in developed countries. The progressive degeneration of articular cartilage characterized as thinner and erosive. Inflammation is well-known to be involved in OA development.
Ming Zhang +6 more
doaj +1 more source
Chalcones and Dihydrochalcones Augment TRAIL-Mediated Apoptosis in Prostate Cancer Cells [PDF]
, 2010 Chalcones and dihydrochalcones exhibit chemopreventive and antitumor activity. TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) is a natural endogenous anticancer agent.
Almasan +24 more
core +2 more sources
Glucose Metabolism Regulating Colorectal Cancer Initiation and Progression
Cancer Science, EarlyView.Drugs and compounds targeting glycolysis in CRC and the mechanisms by which these drugs inhibit their respective targets. ABSTRACT Colorectal cancer (CRC) is one of the most common types of invasive cancer worldwide, which has the characteristics of poor curative effect and poor prognosis. Increasing evidence suggests that hyperactivated glucose uptake
Meiyi Lin, Junpeng Cui
wiley +1 more source
Agricultural Science and Practice, 2018 Introduction. According to the data of foreign studies, prenyl fl avonoids and bitter substances of hop have signifi cant antioxidant, antiviral, antimicrobial, anti-infl ammatory and anti-carcinogenic properties. Methods.
L. Protsenko +4 more
doaj +1 more source
Frontiers in Pharmacology, 2021 Osteoarthritis (OA) is histopathologically marked by extracellular matrix (ECM) degradation in joint cartilage. Abnormal mechanical stimulation on joint cartilage may result in ECM degeneration and OA development.
Tiansheng Zheng +5 more
doaj +1 more source
Isoeugenol is a selective potentiator of camptothecin cytotoxicity in vertebrate cells lacking TDP1 [PDF]
, 2016 Camptothecin (CPT), a topoisomerase I (TOP1) inhibitor, exhibits anti-tumor activity against a wide range of tumors. Redundancy of TOP1-mediated repair mechanisms is a major challenge facing the efficiency of TOP1-targetting therapies. This study aims to
El-Khamisy, S.F. +4 more
core +1 more source
Shipin yu jixieObjectiveTo investigate the interaction mechanism and structure-activity relationship between two hop-derived small molecules different in structure (α-acid and xanthohumol) and barley protein Z.Methodsα-acid and protein Z with high purity are prepared ...
WANG Limin +3 more
doaj +1 more source
Identification of candidate genes affecting Delta9-tetrahydrocannabinol biosynthesis in Cannabis sativa. [PDF]
, 2009 RNA isolated from the glands of a Delta(9)-tetrahydrocannabinolic acid (THCA)-producing strain of Cannabis sativa was used to generate a cDNA library containing over 100 000 expressed sequence tags (ESTs).
Dixon, Richard A +8 more
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