Results 31 to 40 of about 5,333 (223)

Attenuation of Pancreatic Cancer In Vitro and In Vivo via Modulation of Nrf2 and NF-κB Signaling Pathways by Natural Compounds

Cells, 2021
Pancreatic cancer is a disease in which deregulation of signaling pathways plays a key role, thus searching for their novel modulators is a promising therapeutic strategy.
Marta Cykowiak, Robert Kleszcz, Małgorzata Kucińska, Jarosław Paluszczak, Hanna Szaefer, Adam Plewiński, Hanna Piotrowska-Kempisty, Marek Murias, Violetta Krajka-Kuźniak   +8 more
doaj   +1 more source

Chlorella vulgaris biomass enriched by biosorption of polyphenols [PDF]

, 2015
Cell walls of microalgae are variable and contain non-specific domains where different molecules can bind. The enrichment of microalgal biomass with nutrients through adsorption can be an interesting process for the food and feed industry. In this study,
Alvarez-Parrilla, Brányiková, Chojnacka, Dubinin, Friedman, Gerhäuser, Goiris, Hadjoudja, Jullian, Kaneda, Khurana, Kuda, Laborde, Langmuir, Li, Magalhães, Miranda, Monteiro, Mosulishvili, Moure, Ofomaja, Overk, Pandey, Pignolet, Prochazkova, Richard, Sabu, Safarikova, Sarioglu, Sips, Sivakumar, Soleas, Tsai, Wan Maznah, Weber, Wu, Xie, Yao, Zern, Zhang, Zieliñska   +40 more
core   +1 more source

Poly(lactic-co-glycolic acid) Nanoparticles Encapsulating the Prenylated Flavonoid, Xanthohumol, Protect Corneal Epithelial Cells from Dry Eye Disease-Associated Oxidative Stress

Pharmaceutics, 2021
Oxidative stress is a known contributor to the progression of dry eye disease pathophysiology, and previous studies have shown that antioxidant intervention is a promising therapeutic approach to reduce the disease burden and slow disease progression. In
Anita Kirti Ghosh, Rubina Thapa, Harsh Nilesh Hariani, Michael Volyanyuk, Sean David Ogle, Karoline Anne Orloff, Samatha Ankireddy, Karen Lai, Agnė Žiniauskaitė, Evan Benjamin Stubbs, Giedrius Kalesnykas, Jenni Johanna Hakkarainen, Kelly Ann Langert, Simon Kaja   +13 more
doaj   +1 more source

Could Hop-derived Bitter Compounds Improve Glucose Homeostasis by Stimulating the Secretion of GLP-1? [PDF]

, 2019
Hops (Humulus lupulus L.) is by far the greatest contributors to the bitter property of beer. Over the past years, a large body of evidence demonstrated the presence of taste receptors in different locations of the oral cavity.
Annunziata, Giuseppe, Arnone, Angela, Barrea, Luigi, Colao, Annamaria, Muscogiuri, Giovanna, Savastano, Silvia, Tenore, GIAN CARLO   +6 more
core   +1 more source

Promotion of ubiquitination-dependent survivin destruction contributes to xanthohumol-mediated tumor suppression and overcomes radioresistance in human oral squamous cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2020
Background Overexpression of survivin plays a crucial role in tumorigenesis and correlates with poor prognosis in human malignancies. Thus, survivin has been proposed as an attractive target for new anti-tumor interventions.
Ming Li, Feng Gao, Xinfang Yu, Qing Zhao, Li Zhou, Wenbin Liu, Wei Li   +6 more
doaj   +1 more source

Discovery of Serotransferrin Glycoforms: Novel Markers for Diagnosis of Liver Periductal Fibrosis and Prediction of Cholangiocarcinoma. [PDF]

, 2019
Cholangiocarcinoma (CCA) caused by chronic liver fluke infection is a major public health problem in Northeast Thailand. Identification of CCA risk groups is urgently needed for the control of CCA in this region.
Barboza, Mariana, Chamadol, Nittaya, Jamnongkan, Wassana, Khuntikeo, Narong, Lebrilla, Carlito B, Loilome, Watcharin, Pairojkul, Chawalit, Sithithaworn, Paiboon, Techasen, Anchalee, Thanan, Raynoo, Yongvanit, Puangrat   +10 more
core   +2 more sources

Xanthohumol in XERME®, a xanthohumol‐enriched roasted malt extract, and protection of DNA from oxidative damage: evaluation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006

EFSA Journal, 2018
Following an application from TA‐XAN AG, submitted for authorisation of a health claim pursuant to Article 13(5) of Regulation (EC) No 1924/2006 via the Competent Authority of Germany, the EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA ...
EFSA Panel on Dietetic Products, Nutrition and Allergies (NDA), Dominique Turck, Jean‐Louis Bresson, Barbara Burlingame, Tara Dean, Susan Fairweather‐Tait, Marina Heinonen, Karen Ildico Hirsch‐Ernst, Inge Mangelsdorf, Harry J McArdle, Androniki Naska, Monika Neuhäuser‐Berthold, Grażyna Nowicka, Kristina Pentieva, Yolanda Sanz, Anders Sjödin, Martin Stern, Daniel Tomé, Henk Van Loveren, Marco Vinceti, Peter Willatts, Ambroise Martin, Sean (JJ) Strain, Alfonso Siani   +23 more
doaj   +1 more source

Inhibitory Effects and Kinetic-Docking Studies of Xanthohumol From Cones Against Carbonic Anhydrase, Acetylcholinesterase, and Butyrylcholinesterase

Natural Product Communications, 2019
Xanthohumol is an essential prenyl flavonoid of Humulus lupulus L. cones, and the taste of beer is due to this compound. Lately, xanthohumol has earned significant interest due to its potential anticancer, antigenotoxic, and adipogenesis effects. In this
Tuba Aydin, Murat Senturk, Cavit Kazaz, Ahmet Cakir   +3 more
doaj   +1 more source

Plant-derived antivirals against hepatitis c virus infection [PDF]

, 2018
Hepatitis C virus (HCV) infection is a worldwide public health burden and it is estimated that 185 million people are or have previously been infected worldwide.
Harris, M, Jardim, ACG, Rahal, P, Shimizu, JF   +3 more
core   +1 more source

Chemical screening identifies the β-Carboline alkaloid harmine to be synergistically lethal with doxorubicin. [PDF]

, 2017
Despite being an invaluable chemotherapeutic agent for several types of cancer, the clinical utility of doxorubicin is hampered by its age-related and dose-dependent cardiotoxicity.
Ashour, M.E., Atteya, R., El-Khamisy, S.F., Farag, M.A., Ibrahim, E.E.   +4 more
core   +1 more source