Results 21 to 30 of about 5,333 (223)

Safety and Tolerability of Xanthohumol in Adults With Crohn's Disease: Results of a Triple‐Masked, Randomized, Placebo‐Controlled Phase 2 Trial [PDF]

Mol Nutr Food Res
Adults with active Crohn's disease (n = 20) received 24 mg/day of xanthohumol (XN), a bioactive compound derived from Humulus lupulus (hops), for 8 weeks. The study evaluated safety and tolerability through clinical laboratory measures, adverse events, vital signs, anthropometrics, health−related quality of life, and adherence.
Bradley R, A. Staab C, E. Jamieson P, O. Langley B, O. Metz T, F. Stevens J.   +5 more
europepmc   +2 more sources

Microbial transformation of xanthohumol

Phytochemistry, 2003
Microbial transformation of xanthohumol using the culture broth of Pichia membranifaciens afforded three metabolites, (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":4',3']-2', 4-dihydroxy-6'-methoxychalcone, (2S)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":7,8]-4'-hydroxy-5-methoxyflavanone and (E)-2"-(2"'-hydroxyisopropyl)-dihydrofurano[2",3":2 ...
Wimal H M W, Herath, Daneel, Ferreira, Ikhlas A, Khan   +2 more
  +8 more sources

A Combination of Xanthohumol and Ursolic Acid in the Diet Leads to Synergistic Inhibition of Prostate Cancer Progression. [PDF]

Mol Carcinog
ABSTRACT Prostate cancer (PCa) is the second most common cancer and second leading cause of cancer death for American men. Chemoprevention by using phytochemicals offers a promising approach to improve outcomes due to their ability to act on cancer cell metabolism and growth while maintaining low toxicity profiles.
Clark R, Saha A, Lavender Hackman G, Friedman CA, Gorgoglione R, Tiziani S, DiGiovanni J.   +6 more
europepmc   +2 more sources

Xanthohumol microbiome and signature in healthy adults (the XMaS trial): a phase I triple-masked, placebo-controlled clinical trial

Trials, 2020
Background Natural products may provide a source for the discovery and development of adjunctive pharmacological interventions to modulate the inflammatory pathways contributing to chronic disease.
Ryan Bradley, Blake O. Langley, Jennifer J. Ryan, John Phipps, Douglas A. Hanes, Emily Stack, Janet K. Jansson, Thomas O. Metz, Jan Frederik Stevens   +8 more
doaj   +1 more source

Activation of proestrogens from hops (Humulus lupulus L.) by intestinal microbiota; Conversion of isoxanthohumol into 8-prenylnaringenin [PDF]

, 2005
Hop, an essential ingredient in most beers, contains a number of prenylflavonoids, among which 8-prenylnaringenin (8-PN) would be the most potent phytoestrogen currently known. Although a number of health effects are attributed to these compounds, only a
De Keukeleire, Denis, Heyerick, Arne, Possemiers, Sam, Robbens, Veerle, Verstraete, Willy   +4 more
core   +2 more sources

Synthesis of Human Phase I and Phase II Metabolites of Hop (Humulus lupulus) Prenylated Flavonoids

Metabolites, 2022
Hop prenylated flavonoids have been investigated for their in vivo activities due to their broad spectrum of positive health effects. Previous studies on the metabolism of xanthohumol using untargeted methods have found that it is first degraded into 8 ...
Lance Buckett, Sabrina Schönberger, Veronika Spindler, Nadine Sus, Christian Schoergenhofer, Jan Frank, Oliver Frank, Michael Rychlik   +7 more
doaj   +1 more source

Antiviral and antioxidant activity of a hydroalcoholic extract from Humulus lupulus L. [PDF]

, 2018
A hydroalcoholic extract from female inflorescences of Humulus lupulus L. (HOP extract) was evaluated for its anti-influenza activity. The ability of the extract to interfere with different phases of viral replication was assessed, as well as its effect ...
Carissimi, Stefania, Celestino, Ignacio, Checconi, Paola, DE ANGELIS, Marta, DI GIACOMO, Silvia, DI SOTTO, Antonella, Limongi, Dolores, Locatelli, Marcello, Martinoli, Lucia, Nencioni, Lucia, Palamara, ANNA TERESA, Rossi, Valeria, Toniolo, Chiara   +12 more
core   +1 more source

Xanthohumol, a Prenylated Chalcone from Hops, Inhibits the Viability and Stemness of Doxorubicin-Resistant MCF-7/ADR Cells

Molecules, 2016
Xanthohumol is a unique prenylated flavonoid in hops (Humulus lupulus L.) and beer. Xanthohumol has been shown to possess a variety of pharmacological activities.
Ming Liu, Hua Yin, Xiaokun Qian, Jianjun Dong, Zhonghua Qian, Jinlai Miao   +5 more
doaj   +1 more source

Phytochemical characterization of Tabernanthe iboga root bark and its effects on dysfunctional metabolism and cognitive performance in high-fat-fed C57BL/6J mice [PDF]

, 2018
Preparations of the root bark of Tabernanthe iboga have long been used in Central and West African traditional medicine to combat fatigue, as a neuro-stimulant in rituals, and for treatment of diabetes. The principal alkaloid of T.
Akinyeke, Tunde, Alcazar Maganad, Armando, Bading-Taika, Bayissi, Bobe, Gerd, Choie, Jaewoo, L. Miranda, Cristobal, Lione, Lisa, Maier, Claudia S., Ouanesisouk, Michael, Raber, Jacob, Samson Torres, Eileen Ruth, Stevens, Jan F   +11 more
core   +2 more sources

Antiproliferative and apoptotic effects of xanthohumol in cholangiocarcinoma [PDF]

Oncotarget, 2017
Cholangiocarcinoma remains the second most prevalent hepatic neoplasm in the United States with a 5-year survival rate of less than 10%. Currently, no systemic therapy has demonstrated efficacy. Therefore, an urgent need for the identification of molecularly targeted compound(s) remains.
Walden, Daniel, Kunnimalaiyaan, Selvi, Sokolowski, Kevin, Clark, T. Gamblin, Kunnimalaiyaan, Muthusamy   +4 more
openaire   +2 more sources