Results 81 to 90 of about 11,180 (215)

Transcription profiling of the Neurospora crassa response to a group of synthetic (thio)xanthones and a natural acetophenone

Genomics Data, 2015
Xanthones are a class of heterocyclic compounds characterized by a dibenzo-γ-pyrone nucleus. Analysis of their mode of action in cells, namely uncovering alterations in gene expression, is important because these compounds have potential therapeutic ...
A. Pedro Gonçalves, Nuno Silva, Carla Oliveira, David J. Kowbel, N. Louise Glass, Anake Kijjoa, Andreia Palmeira, Emília Sousa, Madalena Pinto, Arnaldo Videira   +9 more
doaj   +1 more source

Synthesis of Novel Xanthone Analogues and Their Growth Inhibitory Activity Against Human Lung Cancer A549 Cells

Drug Design, Development and Therapy, 2019
Purpose Xanthones demonstrated an array of pharmacological activities via non-covalent DNA interaction and have been widely utilized in new drug research.
Junqi Wu, Jinwei Dai, Yuyang Zhang, Jing Wang, Lei Huang, H. Ding, Tiejun Li, Yuefan Zhang, Junqin Mao, Shi-chong Yu   +9 more
semanticscholar   +1 more source

Synthesis, characterization, and computational evaluation of some synthesized xanthone derivatives: focus on kinase target network and biomedical properties

Frontiers in Pharmacology
BackgroundXanthones are dubbed as putative lead-like molecules for cancer drug design and discovery. This study was aimed at the synthesis, characterization, and in silico target fishing of novel xanthone derivatives.MethodsThe products of reactions of ...
Wisam Taher Muslim, Layth Jasim Mohammad, Munaf M. Naji, Isaac Karimi, Matheel D. Al-Sabti, Majid Jabir, Mazin A. A. Najm, Helgi B. Schiöth   +7 more
doaj   +1 more source

Anti-Tumor Xanthones from Garcinia nujiangensis Suppress Proliferation, and Induce Apoptosis via PARP, PI3K/AKT/mTOR, and MAPK/ERK Signaling Pathways in Human Ovarian Cancers Cells

Drug Design, Development and Therapy, 2020
Zhongyan Tang,1,* Lihua Lu,2,* Zhengxiang Xia3 1Department of Emergency and Critical Care Medicine, Jin Shan Hospital, Fudan University, Shanghai 201508, People’s Republic of China; 2Department of Neonatology, International Peace Maternity and ...
Tang Z, Lu L, Xia Z
doaj  

Preparation and characterization of mangiferin-loaded lipid nanocapsules

Archives of Pharmaceutical Sciences Ain Shams University, 2023
Mangiferin (Mgf), a xanthone glucoside of natural origin, is well known to possess different pharmacological actions such as analgesic, antiviral, antidiabetic, anti-inflammatory, hepatoprotective, and antitumor. However, concerning water solubility it
Sara S. Barakat, Maha S. Nasr , Sabry S. Badawy, Nahed D. Mortada   +3 more
doaj  

Semisynthesis and Biological Evaluation of Xanthone Amphiphilics as Selective, Highly Potent Antifungal Agents to Combat Fungal Resistance.

Journal of Medicinal Chemistry, 2017
New efficient antifungal agents are urgently needed to treat drug-resistant fungal infections. Here, we designed and synthesized a series of cationic xanthone amphiphilics as antifungal agents from natural α-mangostin to combat fungal resistance.
S. Lin, Wan-Ling Sin, Jun-Jie Koh, Fanghui Lim, Lin Wang, D. Cao, R. Beuerman, L. Ren, Shouping Liu   +8 more
semanticscholar   +1 more source

Synthesis and spectroscopic properties of β-triazoloporphyrin–xanthone dyads

Beilstein Journal of Organic Chemistry, 2015
A novel series of β-triazoloporphyrin–xanthone conjugates and xanthone-bridged β-triazoloporphyrin dyads has been synthesized in moderate to good yields through Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of copper(II) 2-azido-5,10,15,20 ...
Dileep Kumar Singh, Mahendra Nath
doaj   +1 more source

Structure revision of cryptosporioptides and determination of the genetic basis for dimeric xanthone biosynthesis in fungi

Chemical Science, 2019
Three novel dimeric xanthones, cryptosporioptides A–C were isolated from Cryptosporiopsis sp. 8999 and their structures elucidated.
C. Greco, Kate M. J. de Mattos-Shipley, A. Bailey, N. Mulholland, J. Vincent, C. Willis, Russell John Cox, T. J. Simpson   +7 more
semanticscholar   +1 more source

Coumarins, Xanthones and Related Compounds

Molecules, 2016
It has long been known that coumarins (γ-pyrones) and xanthones (α-pyrones) together form a large class of naturally occurring compounds exhibiting a wide range of biological activities.[...]
openaire   +3 more sources

Xanthone and Flavone Derivatives as Dual Agents with Acetylcholinesterase Inhibition and Antioxidant Activity as Potential Anti-Alzheimer Agents

, 2017
Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder that is associated with the elderly. The current therapy that is used to treat AD is based mainly on the administration of acetylcholinesterase (AChE) inhibitors.
I. Cruz, P. Puthongking, S. Cravo, Andreia Palmeira, H. Cidade, M. Pinto, E. Sousa   +6 more
semanticscholar   +1 more source