Results 11 to 20 of about 144 (112)

Untargeted Metabolomics and Chemometrics Elucidate Dynamic Plasma Profile Changes Induced by Cocoa Shell in Female Rats. [PDF]

Nutrients
This study aimed to explore the effects of cocoa shell extract (CSE) supplementation on the plasma metabolome of female rats. Methods: Female rats were supplemented with CSE (250 mg/kg/day) over seven days, and plasma samples were collected at baseline,
Ramiro-Cortijo D, Rebollo-Hernanz M, Rodríguez-Rodríguez P, Ruvira S, Arribas SM, Martin-Cabrejas MA.   +5 more
europepmc   +3 more sources

Multi-Omics to Illuminate Signaling Molecules of the Gut Microbiota-Brain Axis [PDF]

, 2021
The human gastrointestinal (GI) tract harbors hundreds of trillions of microorganisms, collectively referred to as the gut microbiota. Complex, dynamic, and metabolically active by nature, these commensal microbes carry critical functional roles in ...
Lai, Yunjia
core   +2 more sources

Akkermansia muciniphila Ameliorates Lung Injury in Smoke‐Induced COPD Mice by IL‐17 and Autophagy

Cellular Microbiology, Volume 2023, Issue 1, 2023., 2023
Objective. Smoking is a primary hazard factor for chronic obstructive pulmonary disease (COPD), which induced a decrease in intestinal Akkermansia muciniphila abundance and Th17 imbalance in COPD. This study analyzed the changes of gut microbiota metabolism and Akkermansia abundance in patients with smoking‐related COPD and explored the potential ...
Li Zhang, Junjuan Lu, Caihong Liu, Jayaprakash Narayana Kolla   +3 more
wiley   +1 more source

Treatment With Simvastatin and Rifaximin Restores the Plasma Metabolomic Profile in Patients With Decompensated Cirrhosis

Hepatology Communications, Volume 6, Issue 5, Page 1100-1112, May 2022., 2022
Patients with decompensated cirrhosis, particularly those with acute‐on‐chronic liver failure (ACLF), show profound alterations in plasma metabolomics. The aim of this study was to investigate the effect of treatment with simvastatin and rifaximin on plasma metabolites of patients with decompensated cirrhosis, specifically on compounds characteristic ...
Elisa Pose, Elsa Solà, Juan J. Lozano, Adrià Juanola, Julia Sidorova, Giacomo Zaccherini, Koos de Wit, Frank Uschner, Marta Tonon, Konstantin Kazankov, Cesar Jiménez, Daniela Campion, Laura Napoleone, Ann T. Ma, Marta Carol, Manuel Morales‐Ruiz, Carlo Alessandria, Ulrich Beuers, Paolo Caraceni, Claire Francoz, François Durand, Rajeshwar P. Mookerjee, Jonel Trebicka, Victor Vargas, Salvatore Piano, Hugh Watson, Juan G. Abraldes, Patrick S. Kamath, Mark M. Davis, Pere Ginès, for the investigators of the LIVERHOPE Consortium, M. Schulz, P. Ferstl, I. Giovo, O. Roux, M. Simon‐Talero, M. Pérez‐Guasch, A.B. Rubio, M. Cervera, S. Martínez, N. Fabrellas, J. Pich, A. Vives, E. Avitabile, I. Graupera, C. Solé, O. Bassegoda, J. Gratacós‐Ginès, M. Joyera, E. Palacio, M. Aban, T. Lanzillotti, G. Nicolao, M.T. Chiappa, V. Esnault, R. Andrade, M. Pavesi, M. Korenjak, J. Farrés, M. Serra‐Burriel, P. Angeli   +60 more
wiley   +1 more source

Plasma Metabolites Associated with a Protein‐Rich Dietary Pattern: Results from the OmniHeart Trial

Molecular Nutrition &Food Research, Volume 66, Issue 6, March 2022., 2022
Lack of biomarkers is a challenge for the accurate assessment of protein intake. The present study aims to identify biomarkers of a protein‐rich dietary pattern relative to a carbohydrate‐rich dietary pattern. The study finds that metabolites which represent the protein‐rich dietary pattern include biomarkers of plant protein intake, food or beverage ...
Hyunju Kim, Alice H. Lichtenstein, Karen White, Kari E. Wong, Edgar R. Miller III, Josef Coresh, Lawrence J. Appel, Casey M. Rebholz   +7 more
wiley   +1 more source

Microbe‐associated metabolites as targets for incident type 2 diabetes

Journal of Diabetes Investigation, Volume 12, Issue 4, Page 476-478, April 2021., 2021
Metabolites produced by gut microbiota could be pathogenic or beneficial to the host. Gut microbiota varies among countries, age and sex, there is a possibility that the microbe‐associated metabolites might vary among countries, age and sex. Further studies are required to clarify the relationship among diet, gut microbiota, gut microbiota‐related ...
Yoshitaka Hashimoto, Masahide Hamaguchi, Michiaki Fukui   +2 more
wiley   +1 more source

Metabolomic signatures of cardiac remodelling and heart failure risk in the community

ESC Heart Failure, Volume 7, Issue 6, Page 3707-3715, December 2020., 2020
Abstract Aims Heart failure (HF) is associated with several metabolic changes, but it is unknown whether distinct components of the circulating metabolome may be related to cardiac structure and function, and with incident HF in the community. Methods and results We assayed 217 circulating metabolites in 2336 Framingham Study participants (mean age 55 ±
Charlotte Andersson, Chunyu Liu, Susan Cheng, Thomas J. Wang, Robert E. Gerszten, Martin G. Larson, Ramachandran S. Vasan   +6 more
wiley   +1 more source

UPLC Q‐TOF/MS‐Based Metabolic Profiling of Urine Reveals the Novel Antipyretic Mechanisms of Qingkailing Injection in a Rat Model of Yeast‐Induced Pyrexia

Evidence-Based Complementary and Alternative Medicine, Volume 2013, Issue 1, 2013., 2013
Fever is one of the most common clinical symptoms of many diseases. Qingkailing (QKL) injection is widely used in China as a clinical emergency medicine due to its good antipyretic effects. It is a herbal formula which is composed by eight kinds of traditional Chinese medicines (TCM).
Xiaoyan Gao, Mingxing Guo, Long Peng, Baosheng Zhao, Jiankun Su, Haiyu Liu, Li Zhang, Xu Bai, Yanjiang Qiao, Rong Zeng   +9 more
wiley   +1 more source

Early‐Life Climbing Stratifies the Metabolome and Mortality Risk in Genetically Identical Flies

Aging Cell, Volume 25, Issue 1, January 2026.
Isogenic Drosophila melanogaster vary greatly in longevity. Fractionation of an isogenic cohort based on climbing behavior early in life stratifies variation in the metabolome, longevity and mortality risk offering a tractable system to study intrinsic sources of variation in aging.
Benjamin R. Harrison, Yangxi Sun, Tom Nonacs, Harini Shankar, Danijel Djukovic, Daniel Raftery, Daniel E. L. Promislow   +6 more
wiley   +1 more source

Computing Network of Diseases and Pharmacological Entities through the Integration of Distributed Literature Mining and Ontology Mapping [PDF]

, 2011
The proliferation of -omics (such as, Genomics, Proteomics) and -ology (such as, System Biology, Cell Biology, Pharmacology) have spawned new frontiers of research in drug discovery and personalized medicine.
Faisal, Fazle Elahi
core   +1 more source