Results 21 to 30 of about 144 (112)

Distinctive metabolic disturbances associated with redox homeostasis, nervous and hormonal functions during gut microbial enrichment upon polystyrene microplastic exposure

iMetaOmics, Volume 2, Issue 4, December 2025.
Microplastic‐induced gut microbial enrichment was dominated by bacteria within Eubacteriales, correlated with the virome, and accompanied by colitis. The polyamine synthetic pathway was activated to maintain glutathionylspermidine homeostasis, concurrent with decreases in pathways involved in the production of energy and reactive oxygen species under ...
Guozhu Ye, Zeming Wu, Guoyou Chen, Xuyi Liu, Yifang Duan, Minghui Li, Qiansheng Huang   +6 more
wiley   +1 more source

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, Volume 599, Issue 22, Page 3244-3280, November 2025.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Novel Role of Gut‐Derived Roseburia Intestinalis in Safeguarding Intestinal Barrier Integrity and Microenvironment Homeostasis During Arsenic Exposure

Advanced Science, Volume 12, Issue 42, November 13, 2025.
Arsenic exposure disrupts intestinal barriers and gut microenvironment. Fecal microbiota transplantation (FMT) alleviates arsenic‐induced damage, with gut‐derived Roseburia intestinalis (R.i) identified as a key protective strain. R.i administration counters arsenic toxicity through immunomodulatory pathways and metabolites.
Lixiao Zhou, Chunsong Wang, Jieying Gao, Xu Wu, Geng Li, Xuejun Jiang, Yinyin Xia, Jun Zhang, Bo Lv, Feng Zhao, Hongyang Zhang, Huifeng Pi, Jingfu Qiu, Shangcheng Xu, Zhen Zou, Chengzhi Chen   +15 more
wiley   +1 more source

Effect of a New Skin‐Lightening Cosmetic Containing Cordyceps Extract in the Treatment of Melasma: A Clinical Trial

Journal of Cosmetic Dermatology, Volume 24, Issue 7, July 2025.
ABSTRACT Background Cordyceps is a valuable Chinese herbal medicine known for its various components with antioxidant properties, which may theoretically improve melasma. This study aimed to evaluate the efficacy of a new skin‐lightening cosmetic containing Cordyceps extract (referred to as Cordyceps essence) in treating female patients with melasma ...
Sihao Shen, Huiyi Yao, Yuan Zhu, Wenzhong Xiang   +3 more
wiley   +1 more source

Tryptophan metabolism as a ‘reflex’ feature of neuroimmune communication: Sensor and effector functions for the indoleamine‐2, 3‐dioxygenase kynurenine pathway

Journal of Neurochemistry, Volume 168, Issue 9, Page 3333-3357, September 2024.
The kynurenine pathway functions as a stress‐protection reflex circuit. Indoleamine‐2‐3‐dioxygenase (IDO) is induced by ‘Physical Stressors’ such as infection or tissue damage; tryptophan‐2,3‐dioxygenase (TDO) is activated by psychological pressures via glucocorticosteroids, or elevated dietary tryptophan.
Trevor W. Stone, Richard O. Williams
wiley   +1 more source

Modulation of multiple sclerosis risk and pathogenesis by the gut microbiota: Complex interactions between host genetics, bacterial metabolism, and diet

Immunological Reviews, Volume 325, Issue 1, Page 131-151, August 2024.
Summary Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting nearly 2 million people worldwide. The etiology of MS is multifactorial: Approximately 30% of the MS risk is genetic, which implies that the remaining ~70% is environmental, with a number of factors proposed.
Theresa L. Montgomery, Daniel Peipert, Dimitry N. Krementsov   +2 more
wiley   +1 more source

Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms

Immunity, Inflammation and Disease, Volume 12, Issue 7, July 2024.
Overall the study design of urinary metabolomics related to adrenal suppression in asthmatic children. This study profiled metabolomics of Pharmacogenetics of Adrenal Suppression with Inhaled Steroids (PASS) cohort including 200 children aged 5−18 years who were taking inhaled cortiscosteroids for asthma treatment.
Dung T. Tran, Yulu Chen, Yi Zheng, Julian Hecker, Daniel B. Hawcutt, Munir Pirmohamed, Jessica Lasky‐Su, Ann C. Wu, Kelan G. Tantisira, Michael J. McGeachie, Scott T. Weiss, Amber Dahlin   +11 more
wiley   +1 more source

Integrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

Allergy, Volume 79, Issue 4, Page 949-963, April 2024.
Early‐stage microbial metabolites, reflective of gut dysbiosis steer the development of the immune system toward food allergies. Allergic inflammation appears at the end of the sensitization through a dysregulation in sphingolipid and energy metabolism. Allergic children on an elimination diet suffer from subacute chronic inflammation, as a consequence
Ellen De Paepe, Vera Plekhova, Pablo Vangeenderhuysen, Nele Baeck, Dominique Bullens, Tania Claeys, Marilyn De Graeve, Kristien Kamoen, Anneleen Notebaert, Tom Van de Wiele, Wim Van Den Broeck, Koen Vanlede, Myriam Van Winckel, Lars Vereecke, Chris Elliott, Eric Cox, Lynn Vanhaecke   +16 more
wiley   +1 more source

Placental origins of health & disease:Therapeutic opportunities [PDF]

, 2023
Broekhuizen, Michelle
core   +4 more sources

Xanthurenic Acid Is the Main Pigment of Trichonephila clavata Gold Dragline Silk. [PDF]

Biomolecules, 2021
Fujiwara M, Kono N, Hirayama A, Malay AD, Nakamura H, Ohtoshi R, Numata K, Tomita M, Arakawa K.   +8 more
europepmc   +1 more source