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International Journal of Molecular Sciences, 2020 Due to their multifactorial aspects, mesenchymal stem cells (MSCs) have been widely established as an attractive and potential candidate for the treatment of a multitude of diseases.
Sa Ik Bang +2 more
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Antigen Removal for the Production of Biomechanically Functional, Xenogeneic Tissue Grafts [PDF]
Journal of Biomechanics, 2014 Xenogeneic tissues are derived from other animal species and provide a source of material for engineering mechanically functional tissue grafts, such as heart valves, tendons, ligaments, and cartilage.
Kyriacos A. Athanasiou +2 more
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Annual Review of Immunology, 1998
▪ Abstract This review summarizes the clinical history and rationale for xenotransplantation; recent progress in understanding the physiologic, immunologic, and infectious obstacles to the procedure's success; and some of the strategies being pursued to overcome these obstacles.
H, Auchincloss, D H, Sachs
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▪ Abstract This review summarizes the clinical history and rationale for xenotransplantation; recent progress in understanding the physiologic, immunologic, and infectious obstacles to the procedure's success; and some of the strategies being pursued to overcome these obstacles.
H, Auchincloss, D H, Sachs
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Irradiation for xenogeneic transplantation
Radiotherapy and Oncology, 1990Xenogeneic transplantation (XT) is the transplantation of organs or tissues from a member of one species to a member of another. Mammalian species frequently have circulating antibody which is directed against the foreign organ irrespective of known prior antigen exposure. This antibody may lead to hyperacute rejection.
E C, Halperin +5 more
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The Journal of Immunology, 1976
Abstract Studies were conducted on the mechanism of action of a soluble mediator which was generated in human mixed lymphocyte cultures and assayed for helper activity in T cell-deficient murine spleen cell cultures. The mediator, termed xenogeneic reconstitution factor or XRF, restored the anti-sheep erythrocyte plaque-forming cell ...
John J Farrar, Janet Fuller-Bonar
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Abstract Studies were conducted on the mechanism of action of a soluble mediator which was generated in human mixed lymphocyte cultures and assayed for helper activity in T cell-deficient murine spleen cell cultures. The mediator, termed xenogeneic reconstitution factor or XRF, restored the anti-sheep erythrocyte plaque-forming cell ...
John J Farrar, Janet Fuller-Bonar
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The Journal of Immunology, 1977
Abstract A supernatant from human mixed leukocyte cultures (MLC), Xenogeneic Reconstitution Factor (XRF), was added to one-way murine MLC. This supernatant greatly enhances the generation of cytotoxic cells from C57BL/6 or DBA/2 responder thymocytes, as assayed by a standard 51Cr-release assay.
Philip L Simon +2 more
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Abstract A supernatant from human mixed leukocyte cultures (MLC), Xenogeneic Reconstitution Factor (XRF), was added to one-way murine MLC. This supernatant greatly enhances the generation of cytotoxic cells from C57BL/6 or DBA/2 responder thymocytes, as assayed by a standard 51Cr-release assay.
Philip L Simon +2 more
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Xenogeneic organ transplantation
Current Opinion in Biotechnology, 1996Over the past few years, several major advances have occurred in the understanding of how the humoral and cellular immune system of humans recognizes and destroys transplanted cells, tissues and organs derived from animal sources. Consequently, armed with this new knowledge, several laboratories have now developed novel immunoprotective technologies ...
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A model for xenogenic immune response
Graefe's Archive for Clinical and Experimental Ophthalmology, 2000To develop a model for analyzing the immune response after xenogenic human fetal retinal pigment epithelium (HFRPE) transplantation.Pure sheets of HFRPE cells were isolated and attached to poly (DL-lactide-co-glycolide) polymer films and HFRPE spheroids were formed. The spheroids were transplanted into the subretinal space of New Zealand albino rabbits
K A, Rezai +4 more
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Chemical xenogenization of tumor cells
Trends in Pharmacological Sciences, 1985Abstract Chemical xenogenization occurs when tumor cells cultured in the presence of selected drugs or chemicals become immunogenic, i.e., acquire antigenic foreignness to the host of origin. Unlike modifications induced by haptens, changes in cell immunogenicity associated with chemical xenogenization are heritable as a result of drug interference ...
PUCCETTI, Paolo +2 more
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The Journal of Immunology, 1975
Abstract Modified Marbrook culture vessels with two chambers separated by a 0.2-µ porosity membrane have been utilized to show that antigen-stimulated human lymphocytes produce a soluble factor(s) which restores the ability of thymectomized, irradiated, and bone marrow-protected mice to mount a primary IgM plaque-forming cell response in
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Abstract Modified Marbrook culture vessels with two chambers separated by a 0.2-µ porosity membrane have been utilized to show that antigen-stimulated human lymphocytes produce a soluble factor(s) which restores the ability of thymectomized, irradiated, and bone marrow-protected mice to mount a primary IgM plaque-forming cell response in
openaire +1 more source