Results 51 to 60 of about 92,026 (241)

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Suv4-20h Histone Methyltransferases Promote Neuroectodermal Differentiation by Silencing the Pluripotency-Associated Oct-25 Gene [PDF]

, 2013
Post-translational modifications (PTMs) of histones exert fundamental roles in regulating gene expression. During development, groups of PTMs are constrained by unknown mechanisms into combinatorial patterns, which facilitate transitions from uncommitted
A Barski, A Magklara, AK Teo, Anne C. Ferguson-Smith, BM Lee, CD Rogers, CS Hinkley, Dario Nicetto, E Meshorer, E Meshorer, G Schotta, G Schotta, GM Morrison, Gunnar Schotta, H Niwa, I Munoz-Sanjuan, JH Lee, Julia Jung, K Takebayashi-Suzuki, L Yang, LA Banaszynski, LA Boyer, LA Boyer, M Hemberger, M Snir, M Tachibana, M Thomson, Matthias Hahn, N Singhal, NL Vastenhouw, NS Christophersen, P Kapoor-Vazirani, R Cao, R David, Ralph A. W. Rupp, RC Akkers, Robert David, S Dambacher, S Rea, SA Blythe, SC Dillon, SR Bhaumik, SV Saladi, T Hashimshony, T Hollemann, T Kwon, TD Schneider, Tobias D. Schneider, Tobias Straub, TS Mikkelsen, U Hellsten, VL Biron, WA Harris, Y Cao, Y Cao, Y Cao, Y Zhang, Z Li   +57 more
core   +3 more sources

A database of microRNA expression patterns in Xenopus laevis [PDF]

, 2015
MicroRNAs (miRNAs) are short, non-coding RNAs around 22 nucleotides long. They inhibit gene expression either by translational repression or by causing the degradation of the mRNAs they bind to.
A Hemmati-Brivanlou, A Kozomara, AA Bazzini, AD Wylie, Ali H Brivanlou, Andrea E. Münsterberg, Ayisha Ahmed, BP Lewis, Camille Viaut, D Sweetman, D Sweetman, Dario Dotlic, DK Darnell, DP Bartel, E Bonnet, E Wienholds, G Hutvagner, G Martello, Grant N. Wheeler, Ilya Patrushev, J Krol, JB Bowes, JB Karpinka, JC Walker, K Goljanek-Whysall, K Goljanek-Whysall, M Harrison, Matthew L. Tomlinson, MB Stocks, Michael J. Gilchrist, MJ Gilchrist, MJ Hawrylycz, MS Ebert, Nicole J. Ward, PD Nieuwkoop, R Agrawal, R Lorenz, S Lopez-Gomollon, Sara Lopez-Gomollon, SD Hsu, Simon Moxon, SJ Hubbard, T Watanabe, Tamas Dalmay, Y Lee, Y Lee, Y Zhao   +46 more
core   +8 more sources

A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling, Mark D. Parker, Sven Kerst, Richard A. Pasternack, Jacob Tondreau, Marjolein Breur, Gemma M. van Rooijen‐van Leeuwen, Davide Tonduti, Ettore Salsano, Alejandra Darling, Joanna A. E. van Wijk, Susanna Törnroth‐Horsefield, Marianna Bugiani, Petra J. W. Pouwels, Quinten Waisfisz, Marjo S. van der Knaap, Rogier Min   +16 more
wiley   +1 more source

Malectin Alleviates Endoplasmic Reticulum Stress in Gestational Diabetes Mellitus via Glycoprotein Quality Control Mechanisms

Advanced Science, EarlyView.
Malectin alleviates high glucose‐induced ER stress and damage in placental trophoblasts, a function dependent on its six critical carbohydrate‐binding residues. In a GDM mouse model, administration of TAT‐Malectin ameliorated hyperglycemia and placental ER stress and prevented fetal macrosomia.
Jiahui Zhu, Yumeng Zhang, Ye Wang, Xiaoyu Zhu, Ailin Yuan, Weijing Yin, Huangmin Yu, Xuemin Pang, Yufeng He, Yuchen Wang, Tong Wang, Yong Li, Yunlong Si   +12 more
wiley   +1 more source

Fish and amphibians as test organisms for evaluation of effects caused by chemicals [PDF]

, 2007
A large number of chemicals can contaminate aquatic environments and therefore be exposed to fish and amphibians during their sensitive stages of development.
Carlsson, Gunnar
core  

Evaluation of the genotoxic and teratogenic potential of a municipal sludge and sludge-amended soil using the amphibian Xenopus laevis and the tobacco: Nicotiana tabacum L. var. xanthi Dulieu [PDF]

, 2003
The toxic, genotoxic and teratogenicpotential of amunicipal sewage sludge was assessed using the micronucleus assay on the larvae of the amphibianXenopuslaevis and with the tobacco somatic mutation test using the yellow–green xanthiDulieu mutant a1+/a1 ...
Chenon, Pascale, Delpoux, Marcel, Gauthier, Laury, Loubières, Pascale, Séverac, Alain   +4 more
core   +4 more sources

Xenopus laevisas UberXL for nematodes [PDF]

African Zoology, 2020
The effect of invasive species on local parasite dynamics is often overlooked. The African Clawed Frog Xenopus laevis (Daudin, 1802) (Anura: Pipidae) is a global invader, with established populations on four continents and is a domestic exotic in southern Africa.
Anneke L Schoeman, Tracy-Lee Joubert, Louis H du Preez, Roman Svitin   +3 more
openaire   +2 more sources

Functional Analysis of Ligand‐Gated Chloride Channels in a Cnidarian Sheds Light on the Evolution of Inhibitory Signaling

Advanced Science, EarlyView.
We uncover a large variety of putative inhibitory ligand‐gated ion channels (LGICs) in the phylum Cnidaria, the sister group to all bilaterian animals. Phylogenetic analysis suggests a complex evolutionary history of inhibitory LGICs with diverse neurotransmitter ligands.
Abhilasha Ojha, Linda Kloss, Juan D. Montenegro, Simone Albani, Audrey Ortega‐Ramírez, Mihaela Raycheva, Sylvia Joussen, Sabrina Kaul, Michèle Bachmann, Lisa Huf, Günther Schmalzing, Alison G. Cole, Ulrich Technau, Stefan Gründer   +13 more
wiley   +1 more source

Acquisition of Leftward Flow in Xenopus laevis

Bio-Protocol, 2013
In Xenopus, the left-right axis is established following an extracellular vectorial leftward flow driven by monocilia at the gastrocoel roof plate (GRP) during late gastrulation / neurulation (Schweickert et al., 2007).
Thomas Thumberger, Martin Blum
doaj   +1 more source