Towards the spatial resolution of metalloprotein charge states by detailed modeling of XFEL crystallographic diffraction. [PDF]
, 2020 Oxidation states of individual metal atoms within a metalloprotein can be assigned by examining X-ray absorption edges, which shift to higher energy for progressively more positive valence numbers.
Holton, James M +3 more
core +2 more sources
XFEL structures of the human MT2 melatonin receptor reveal basis of subtype selectivity
Nature, 2019 The human MT1 and MT2 melatonin receptors1,2 are G-protein-coupled receptors (GPCRs) that help to regulate circadian rhythm and sleep patterns3. Drug development efforts have targeted both receptors for the treatment of insomnia, circadian rhythm and ...
L. Johansson +23 more
semanticscholar +1 more source
Analysis Strategies for MHz XPCS at the European XFEL
Applied Sciences, 2021 The nanometer length-scale holds precious information on several dynamical processes that develop from picoseconds to seconds. In the past decades, X-ray scattering techniques have been developed to probe the dynamics at such length-scales on either ...
F. Dallari +9 more
semanticscholar +1 more source
Megahertz data collection from protein microcrystals at an X-ray free-electron laser
Nature Communications, 2018 The European X-ray free-electron laser (EuXFEL) in Hamburg is the first megahertz (MHz) repetition rate XFEL. Here the authors use lysozyme crystals and microcrystals from jack bean proteins and demonstrate that damage-free high quality data can be ...
Marie Luise Grünbein +55 more
doaj +1 more source
Single-Shot Coherent X-ray Imaging Instrument at PAL-XFEL
Applied Sciences, 2021 We developed a single-shot coherent X-ray imaging instrument at the hard X-ray beamline of the Pohang Accelerator Laboratory X-ray Free Electron Laser (PAL-XFEL).
Daeho Sung +14 more
semanticscholar +1 more source
First functionality tests of a 64 x 64 pixel DSSC sensor module connected to the complete ladder readout [PDF]
, 2017 The European X-ray Free Electron Laser (XFEL.EU) will provide every 0.1 s a train of 2700 spatially coherent ultrashort X-ray pulses at 4.5 MHz repetition rate.
Donato, Mattia +7 more
core +2 more sources
A split-beam probe-pump-probe scheme for femtosecond time resolved protein X-ray crystallography [PDF]
, 2015 In order to exploit the femtosecond pulse duration of X-ray Free-Electron Lasers (XFEL) operating in the hard X-ray regime for ultrafast time-resolved protein crystallography experiments, critical parameters that determine the crystallographic signal-to ...
Madsen, A, Van Thor, JJ
core +2 more sources
Nature Methods, 2018 New X-ray free-electron (XFEL) facilities will broaden access to this technology, facilitate methods development, and push boundaries in structural biology.
openaire +1 more source
Spatiotemporal dynamics of fast electron heating in solid-density matter via XFEL
Nature CommunicationsHigh-intensity, short-pulse lasers are crucial for generating energetic electrons that produce high-energy-density (HED) states in matter, offering potential applications in igniting dense fusion fuels for fast ignition laser fusion. High-density targets
H. Sawada +20 more
semanticscholar +1 more source
Data reduction activities at European XFEL: early results
Frontiers in PhysicsThe European XFEL is a megahertz repetition-rate facility producing extremely bright and coherent pulses of a few tens of femtoseconds duration. The amount of data generated in the context of user experiments can exceed hundreds of gigabits per second ...
Egor Sobolev +35 more
doaj +1 more source