Results 131 to 140 of about 35,510 (301)

CCDC97 is a Promising Predictor in Cancer Diagnosis: A Pan Cancer Analysis

Analytical Cellular Pathology, Volume 2026, Issue 1, 2026.
Background Coiled‐coil domain‐containing 97 (CCDC97) can bind to the splicing factor SF3B complex to participate significantly in pre‐mRNA splicing. However, there may be a risk of cancer development in the case of disrupted mechanism, necessitating further in‐depth investigation of the underlying mechanism.
Changye Yang, Ruirui Yang, Rundong Wang, Guo Ma, Lixin Hua, Maciej Wnuk   +5 more
wiley   +1 more source

Epigenetic silencing of X-chromosome [PDF]

, 2012
Komosomi X su spolni kromosomi koji nose velik broj gena koji nisu povezani sa spolnom determinacijom i reprodukcijom već kontroliraju različite metaboličke puteve. Kod ženki sisavaca dolazi do mehanizma kompenzacije doze zbog postojanja dva kromomsoma X.
Kužet, Sanya Eduarda
core   +2 more sources

Molecular Landscape and Predictive Significance of Programmed Cell Death‐Related Genes in Sepsis

Human Mutation, Volume 2026, Issue 1, 2026.
Sepsis, a systemic inflammatory response to infection, remains a significant health challenge with high morbidity and mortality rates. The molecular mechanisms underlying sepsis, particularly the role of programmed cell death (PCD), are not fully understood.
Shiqiang Min, Tao Zhang, Song Chen, Minghua Ren   +3 more
wiley   +1 more source

The lncRNA XIST promotes colorectal cancer cell growth through regulating the miR-497-5p/FOXK1 axis

Cancer Cell International, 2020
Background Recent studies suggest that long noncoding RNAs (lncRNAs) play an important role in tumorigenesis. As a newly identified lncRNA, the role of XIST in colorectal cancer (CRC) has not been established.
Nan Wang, Jia-Xing He, Guo-Zhan Jia, Ke Wang, Shuai Zhou, Tao Wu, Xian-Li He   +6 more
doaj   +1 more source

The role of UPR‐related long noncoding RNAs in development of endocrine resistance in breast cancer

International Journal of Cancer, Volume 157, Issue 12, Page 2434-2446, 15 December 2025.
Abstract Breast cancer patients who express estrogen receptor α (ER) typically receive endocrine therapy as a first‐line treatment. Most ER‐positive breast cancer patients initially respond to endocrine therapy, but up to 40% of patients develop resistance over time, and the main mechanism is aberrant activation of ER signaling pathways.
Wen Liu, Sahil Gupta, Sanjeev Gupta
wiley   +1 more source

Xist comparative genomics

Genome Biology, 2001
The primary sequence of Xist seems not to be important for Xist to function in X-chromosome inactivation.
openaire   +1 more source

Epigenomes in Cardiovascular Disease. [PDF]

, 2018
If unifying principles could be revealed for how the same genome encodes different eukaryotic cells and for how genetic variability and environmental input are integrated to impact cardiovascular health, grand challenges in basic cell biology and ...
McKinsey TA, Morimoto T, Poller W, Turner BM, Wang Y   +4 more
core   +1 more source

De-erosion of X chromosome dosage compensation by the editing of XIST regulatory regions restores the differentiation potential in hPSCs

, 2022
Nami Motosugi, Akiko Sugiyama, Chisa Okada, Asako Otomo, Akihiro Umezawa, Hidenori Akutsu, Shinji Hadano, Atsushi Fukuda   +7 more
openalex   +1 more source

Retraction: LncRNA XIST promotes the progression of laryngeal squamous cell carcinoma via sponging miR-125b-5p to modulate TRIB2 [PDF]

, 2022

openalex   +1 more source

How does the Xist activator Rlim/Rnf12 regulate Xist expression?

Biochemical Society Transactions
The long non-coding RNA (lncRNA) Xist is crucially involved in a process called X chromosome inactivation (XCI), the transcriptional silencing of one of the two X chromosomes in female mammals to achieve X dosage compensation between the sexes. Because Xist RNA silences the X chromosome from which it is transcribed, the activation of Xist transcription
Feng Wang, Poonam Mehta, Ingolf Bach
openaire   +2 more sources