Results 111 to 120 of about 16,717 (221)

Xist comparative genomics

Genome Biology, 2001
The primary sequence of Xist seems not to be important for Xist to function in X-chromosome inactivation.
openaire   +1 more source

Transient Xist-ence [PDF]

Cell, 1997
Kuroda, Mitzi I., Meller, Victoria H.
openaire   +2 more sources

Xist gene regulation at the onset of X inactivation.

, 2009
The large non-coding RNA Xist is the master regulator of X inactivation. Xist is negatively regulated by its antisense transcript Tsix. This repressive antisense transcription across Xist operates at least in part through the modification of the ...
Brockdorff, Neil, Brockdorff, N, Senner, CE   +2 more
core   +1 more source

Role of lncRNA XIST/miR-146a Axis in Matrix Degradation and Apoptosis of Osteoarthritic Chondrocytes Through Regulation of MMP-13 and BCL2

Biology
Growing evidence demonstrates the critical roles of long non-coding RNAs (lncRNAs) in osteoarthritis (OA) pathogenesis. The lncRNA XIST is one of the most commonly studied; however, its function remains unclear. This study aimed to research the molecular
Sara Cheleschi, Nicola Mondanelli, Iole Seccafico, Roberta Corsaro, Elena Moretti, Giulia Collodel, Antonella Fioravanti   +6 more
doaj   +1 more source

Impact of somatic XIST deletions on ongoing XIST expression and inactive X silencing and heterochromatin

Human Molecular Genetics
Abstract The long non-coding RNA XIST is critical for establishing X-chromosome inactivation early in development. XIST remains expressed from the inactive X throughout female life; yet in somatic cells silencing of most genes continues in the absence of XIST.
Karanveer S Bhangu, Christine Yang, Hannah J Illing, Carolyn J Brown   +3 more
openaire   +2 more sources

Study of Xist-mediated gene silencing using iXist

, 2015
X Chromosome Inactivation (XCI) is an example of dosage compensation in mammals in which one of the X chromosomes in females is inactivated to balance the gene dosage between males and females.
Tan, Jin Da
core  

Discovering therapeutic possibilities for polycystic ovary syndrome by targeting XIST and its associated ceRNA network through the analysis of transcriptome data

Scientific Reports
Long non-coding RNA (lncRNA) regulates many physiological processes by acting as competitive endogenous RNA (ceRNA). The dysregulation of lncRNA X-inactive specific transcript (XIST) has been shown in various human disorders.
Elahe Berenji, Ali Valipour Motlagh, Marziyeh Fathi, Maryam Esmaeili, Tayebeh Izadi, Parsa Rezvanian, Maryam Zanjirband, Zahra Safaeinejad, Mohammad Hossein Nasr-Esfahani   +8 more
doaj   +1 more source

Xist transgenic culture systems and Xist+ human pluripotent stem cells reveal transcriptional targets of Xist.

We identify here through the study of total transcription in human cells engineered to express an Xist transgene, and in human pluripotent stem cells selected at the clonal level for Xist positivity (Xist+ hES), and proteomic study of Xist interacting proteins a network of epigenetic molecules whose expression is controlled by Xist.
openaire   +1 more source

xIST and COPPER

, 2016
We have releases two pieces of code: Firstly the xIST package, an extension of the xAct tensor algebra system, which implements a framework to investigate general scalar-tensor theories at the level of linear perturbations.
Baker, T, Noller, J, Lagos Urbina, MA, Ferreira, P   +3 more
core  

LncRNA XIST promotes neovascularization in diabetic retinopathy by regulating miR-101-3p/VEGFA

Archives of Endocrinology and Metabolism
Objective: This study sought to investigate the regulation of long noncoding RNA (lncRNA) XIST on the microRNA (miR)-101-3p/vascular endothelial growth factor A (VEGFA) axis in neovascularization in diabetic retinopathy (DR).
Weina Fu, Yunyan Ye, Feng Hu
doaj   +1 more source