Results 51 to 60 of about 1,075 (125)

Renal Cell Carcinoma Associated with Xp11.2 Translocation/TFE3 Gene Fusion: A Rare Case Report with Review of the Literature

Case Reports in Urology, 2013
Introduction. The recently recognized renal cell carcinomas associated with Xp11.2 translocations are rare tumors predominantly reported in children. Chromosome Xp11.2 translocation results in gene fusion related to transcription factor E3 (TFE3) that ...
Puneet Ahluwalia, Balagopal Nair, Ginil Kumar   +2 more
doaj   +1 more source

The preliminary experiences of translocation renal cell carcinoma and literature review

Kaohsiung Journal of Medical Sciences, 2014
Xp11.2 translocation renal cell carcinoma (RCC) is rare and predominantly found in children and young adults. Because of the property of overexpressed transcription factor E3 (TFE3) fusion protein, immunohistochemical (IHC) staining with TFE3 antibody ...
Hsin-Hao Su, Ming-Tse Sung, Po-Hui Chiang, Yunan-Tso Cheng, Yen-Ta Chen   +4 more
doaj   +1 more source

HIF1α Plays a Crucial Role in the Development of TFE3–Rearranged Renal Cell Carcinoma by Orchestrating a Metabolic Shift Toward Fatty Acid Synthesis

Genes to Cells, Volume 30, Issue 1, January 2025.
This graphical abstract illustrates the key metabolic changes in TFE3–rearranged renal cell carcinoma (TFE3‐RCC). The PRCC‐TFE3 fusion protein upregulates HIF1α, leading to enhanced glycolysis and lipid synthesis through SREBP1 activation. This metabolic shift, characterized by increased glucose uptake, fatty acid synthesis, and reduced ketogenesis ...
Hidekazu Nishizawa, Shintaro Funasaki, Wenjuan Ma, Yoshiaki Kubota, Kazuhide Watanabe, Yuichiro Arima, Shoichiro Kuroda, Takaaki Ito, Mitsuko Furuya, Takanobu Motoshima, Akira Nishiyama, Sally Mehanna, Yorifumi Satou, Hisashi Hasumi, Ryosuke Jikuya, Kazuhide Makiyama, Tomohiko Tamura, Yuichi Oike, Yasuhito Tanaka, Toshio Suda, Laura S. Schmidt, W. Marston Linehan, Masaya Baba, Tomomi Kamba   +23 more
wiley   +1 more source

TFE3‐rearranged nonmelanotic renal PEComa: a case series expanding their phenotypic and fusion landscape

Histopathology, Volume 85, Issue 5, Page 783-793, November 2024.
TFE3‐rearranged renal PEComas display high cytomorphological diversity with clear, eosinophilic, or mixed cell types, but lack significant anaplasia and pleomorphism. Their phenotypic diversity is paralleled by the diversity of their TFE3 gene fusion partner landscape. Homogeneous and strong TFE3 expression is characteristic.
Abbas Agaimy, Andres M Acosta, Liang Cheng, Katrina Collins, Eddie Fridman, Christoph Schubart, Sean R Williamson, Arndt Hartmann, Kiril Trpkov   +8 more
wiley   +1 more source

The potential value of cancer‐testis antigens in ovarian cancer: Prognostic markers and targets for immunotherapy

Immunity, Inflammation and Disease, Volume 12, Issue 6, June 2024.
Cancer‐testis antigens (CTAs) exhibit carcinogenic potential and strong immunogenicity in ovarian cancer. This review outlines a comprehensive of overview the regulatory mechanism, immunogenicity, clinical expression significance, tumorigenesis, and application prospects of CTAs in ovarian cancer, all of which can provide novel insights in the ...
Lina Lin, Xiaoqiong Zou, Weixia Nong, Yingying Ge, Feng Li, Bin Luo, Qingmei Zhang, Xiaoxun Xie   +7 more
wiley   +1 more source

Percutaneous radiofrequency ablation on a Xp11.2 Translocation Renal Cell Carcinoma: A case report

Urology Case Reports, 2020
Xp11.2 Translocation Renal Cell Carcinoma is a very rare subtype of renal neoplasm. The present report describes the first confirmed reported case of percutaneous ablation of this subtype of tumor.
Alexandre Fligelman Kanas, Marcello Silveira Rovella, Mauricio Ruettimann Liberato de Moura, Katia Ramos Moreira Leite, Miguel Srougi, Marcos Roberto de Menezes   +5 more
doaj   +1 more source

A nomogram based on TFE3 IHC results and clinical factors as a preliminary screening scheme for TFE3‐rearranged renal cell carcinoma

Cancer Medicine, Volume 13, Issue 5, March 2024.
Abstract Background TFE3 immunohistochemistry (TFE3‐IHC) is controversial in the diagnosis of TFE3‐rearranged renal cell carcinoma (TFE3‐rearranged RCC). This study is to investigate the accuracy and sensitivity of IHC and establish a predictive model to diagnose TFE3‐rearranged RCC.
Pengju Li, Quanhui Xu, Minyu Chen, Jiangquan Zhu, Yinghan Wang, Mukhtar A. Mumin, Kangbo Huang, Zeying Jiang, Hui Liang, Qiong Deng, Zhu Wang, Bing Liao, Wenfang Chen, Yun Cao, Jiazheng Cao, Junhang Luo   +15 more
wiley   +1 more source

Targeted therapies in children with renal cell carcinoma (RCC): An International Society of Pediatric Oncology—Renal Tumor Study Group (SIOP‐RTSG)‐related retrospective descriptive study

Cancer Medicine, Volume 13, Issue 1, January 2024.
This is the first SIOP‐RTSG retrospective study that reports response‐ and survival data of pediatric patients with renal cell carcinoma (RCC) who were treated with targeted therapy. Thirty‐one patients with advanced‐stage RCC were treated with 17 different treatment regimens, highlighting current treatment heterogeneity.
Julia Sprokkerieft, Justine N. van der Beek, Filippo Spreafico, Barbara Selle, Estelle Thebaud, Tanzina Chowdhury, Jesper Brok, Gábor Ottóffy, Xiaofei Sun, Gema L. Ramírez Villar, Garik Sagoyan, Heidi Segers, Dimitrios Doganis, Annalisa Serra, Lauriane Lemelle, Norbert Graf, Arnauld C. Verschuur, Godelieve A. M. Tytgat, Marry M. van den Heuvel‐Eibrink   +18 more
wiley   +1 more source

Xp11.2 translocation renal cell carcinoma occurring during pregnancy with a novel translocation involving chromosome 19: a case report with review of the literature

Diagnostic Pathology, 2009
The recently recognized renal cell carcinomas (RCCs) associated with Xp11.2 translocations (TFE3 transcription factor gene fusions) are rare tumors predominantly reported in children.
Surti Urvashi, Parwani Anil V, Armah Henry B, Bastacky Sheldon I   +3 more
doaj   +1 more source

Concomitant presentation and surgical management of an abdominal aortic aneurysm and translocation XP11.2 associated renal cell carcinoma in a female infant

Journal of Pediatric Surgery Case Reports, 2018
Abdominal Aortic Aneurysms are rare in the infant population, when these occur are secondary to connective tissue diseases, vasculitis, and infectious etiology or in relation with tuberous sclerosis.
Ramón Garcia–Alva, Javier E. Anaya-Ayala, Gabriel Lopez-Pena, Lizeth Luna, Cesar Cuen-Ojeda, Rene Lizola, Eduardo Lopez-Corella, Carlos A. Hinojosa   +7 more
doaj   +1 more source