Results 91 to 100 of about 150,572 (297)

Syringe services program staff and participant perspectives on changing drug consumption behaviors in response to xylazine adulteration

Harm Reduction Journal
Background Xylazine is an increasingly common adulterant in the North American unregulated drug supply that is associated with adverse health outcomes (e.g., skin infections, overdose). However, there are significant knowledge gaps regarding how xylazine
William H. Eger, Marina Plesons, Tyler S. Bartholomew, Angela R. Bazzi, Maia H. Hauschild, Corbin C. McElrath, Cyrus Owens, David W. Forrest, Hansel E. Tookes, Erika L. Crable   +9 more
doaj   +1 more source

Anaesthetic effects of xylazine combinations in high and low concentrations of tiletamine-zolazepam, with and without ketamine, in cats [PDF]

, 2005
Intramuscular (1M) administration of four anaesthetic combinations were evaluated on nine cats ina repeated manner. The anaesthetic regimens were: (i) 2 mg/kg tiletamine, 2 mg/kg zolazepam, 3.2 mg/kg ketamine and 0.8 mg/kg xylazine (T₄KX); (ii) 1 mg/kg ...
Chee, S. K., Chen, Hui Cheng
core  

Photodynamic Priming and Minocycline Overcome Chemoresistance by Reprogramming the Pancreatic Tumor Immune Microenvironment In Vivo

Advanced Science, EarlyView.
Dual priming with minocycline and photodynamic priming reprograms the pancreatic tumor microenvironment to overcome chemoresistance. By suppressing DNA repair enzyme Tdp1, inducing photooxidative damage, and enhancing irinotecan delivery via light‐activated nanoencapsulation, this strategy remodels the tumor microenvironment and drives immune ...
Fernanda V. Cabral, Jose Quilez‐Alburquerque, Olivia Mooradian, Shivendran Vytheswarran, Badri Parshad, Girgis Obaid, Huang‐Chiao Huang, Tayyaba Hasan   +7 more
wiley   +1 more source

Btp Proteins from Brucella abortus Modulate the Lung Innate Immune Response to Infection by the Respiratory Route [PDF]

, 2017
Although inhalation of infected aerosols is a frequent route for Brucella infection in humans, it rarely causes pulmonary clinical manifestations, suggesting a mild or nearly absent local inflammatory response.
Baldi, Pablo Cesar, Comerci, Diego José, Falivene, Juliana, Fernandez, Andrea Giselle, Ferrero, Mariana Cristina, Hielpos, María Soledad, Vanzulli, Silvia   +6 more
core   +1 more source

A preclinical mouse model mimicking the ovarian cancer‐induced estrogen deficiency‐depression axis

Animal Models and Experimental Medicine, EarlyView.
A preclinical mouse model of ovarian cancer–related depression was developed by combining intraperitoneal tumor cell injection, ovariectomy, and chronic restraint stress. The model replicates key clinical features including estrogen deficiency, depressive‐like behaviors, and tumor progression, and provides a reliable tool for studying the endocrine ...
Jiamin Liu, Yafei Yang, Chunxi Liu, Danting Wen, Tingyu Zhao, Ping Xie, Jing Xiao   +6 more
wiley   +1 more source

Presumptive Tests for Xylazine—A Computer Vision Approach

Analytical Science Advances
Abuse of xylazine is an immediate global public health concern. We report the distinct and measurable colour changes when xylazine is exposed to the Mandelin, Marquis and Mecke presumptive test reagents.
Hui Yun Chang, Kristin Donnachie, Timothy J. D. McCabe, Henry Barrington, Felicity Carlysle‐Davies, Kristin Ceniccola‐Campos, Marc Reid   +6 more
doaj   +1 more source

Effects of ketamine/xylazine premedication on emulsified isoflurane general anaesthesia in swine undergoing embryo transplantation

Veterinární Medicína, 2014
Cardiorespiratory effects were assessed during ketamine/xylazine premedication followed by emulsified isoflurane anaesthesia in swine undergoing experimental embryo transplantation.
S. Jiang, K. Hu, H.G. Fan, B.S. Yin, X. Li, J.L. Hou, H.B. Wang   +6 more
doaj   +1 more source

Phenotypic profiling of pristane‐induced mimicking human systemic lupus erythematosus in Macaca fascicularis

Animal Models and Experimental Medicine, EarlyView.
Pristane (5 mL/kg) induced a robust systemic lupus erythematosus (SLE)‐like phenotype in Macaca fascicularis, marked by elevated antinuclear antibody (ANA) levels and systemic clinical, hematological, and biochemical changes. This model closely reflects human SLE and provides a translational platform for disease studies and therapeutic evaluation ...
Jonny Jonny, Soetojo Wirjopranoto, Chairul A. Nidom, I Ketut Sudiana, Terawan A. Putranto, Elisa D. Pratiwi, Tiza W. Mawaddah, Astria N. Nidom, Reviany V. Nidom, Setyarina Indrasari, Irma Y. Rosytania, Hiqmah Y. Yana, Sanindita Kusumastuti   +12 more
wiley   +1 more source

A microscopically assisted limited colectomy mouse model of early colon cancer

Animal Models and Experimental Medicine, EarlyView.
Establishment, surgery, and evaluation process of a microscope‐assisted limited colon resection mouse model for early‐stage colon cancer. Abstract Background Currently, there is a lack of an adequate rodent model for investigating surgical techniques and comprehensive treatment options for patients with colorectal cancer (CRC).
Yu Han, Yixin Zhang, Dazhi Gao, Xuefeng Zhao   +3 more
wiley   +1 more source

Opioid‐related xylazine toxicity manifesting as myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema

Journal of the American College of Emergency Physicians Open
This article provides a report of a case of organ dysfunction, myonecrosis, rhabdomyolysis, multifocal ischemic cerebral infarcts, and cerebral edema after a patient's use of xylazine and fentanyl. Within the US opioid epidemic, xylazine is emerging as a
Ogechi Nwodim, Ritesh Karsalia, Mark E. Heslin, Allyson E. Lieberman, Sally Zehui Wang, Atul A. Kalanuria, Holly C. Elser, Bernd Driessen, Christopher Caruso, George L. Anesi   +9 more
doaj   +1 more source