Results 121 to 130 of about 119,267 (282)

Xylazine: a public health crisis amidst an overdose epidemic

2024Interactions between opioids and xylazine are increasing overdose risks and perpetuating problematic health outcomes. The appearance and proliferation of xylazine have contributed to the lethality of the illicit drug supply, which is becoming ...
Rust, Victoria Silva
core   +1 more source

Seizure activity after xylazine administration in a horse

, 2017
A vicious stallion, schedule for castration, became very stressed during the attempts to place a jugular catheter. Finally, xylazine was injected direcdy from the syringe into the jugular vein and immediately the animal fell down and developed seizures ...
I. SAVVAS (Ι. ΣΑΒΒΑΣ)
core   +1 more source

Repeated Exposure to a Hair Bleaching Mixture Alters cGAS–STING Pathway Transcripts in Mice

Journal of Applied Toxicology, EarlyView.
ABSTRACT Hair bleaching products commonly contain ammonia and hydrogen peroxide, chemicals capable of generating reactive oxygen species (ROS). However, their effects on innate immune signaling pathways associated with DNA damage remain poorly understood.
Leticia Rodrigues Sampaio, Marjori Lima Boblitz Parente, Ronald Feitosa Pinheiro   +2 more
wiley   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

Journal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo, Gabriel Carvalhal de Aguiar, Daniel Vitor Souza, Barbara dos Anjos Rosário, Flavia de Oliveira, Fernando Augusto Cintra Magalhaes, Nágila Maria Pontes Silva Ricardo, Edilberto Rocha Silveira, Dávila Zampieri, Milena de Barros Viana, Daniel Araki Ribeiro   +10 more
wiley   +1 more source

Xylazine in overdose deaths and forensic drug reports in US States, 2019-2022.

Importance: Xylazine is increasingly reported in street drugs and fatal overdoses in the US, yet state-level data are limited, hampering local public health responses.
Marsiglia, Flavio, Daniulaityte, Raminta, Cano, Manuel   +2 more
core   +1 more source

Cardiac Histomorphometric Implications Resulting From Chronic Nandrolone Decanoate Treatment in Rats Subjected to Resistance Training

Journal of Applied Toxicology, EarlyView.
ABSTRACT The effects of anabolic steroid abuse on the cardiac tissue of resistance training practitioners are poorly understood. Herein, we present the histomorphometric implications of resistance training in rats treated with nandrolone decanoate, an androgenic anabolic steroid. Eighteen‐week‐old male Wistar rats (N = 32) were divided into two groups (
Lucas D. Ferreira, Tallys E. Velasco, Bruno A. Aguilar, João V. M. Bernal, Gabriel A. Lavez, João P. Passaglia, Hugo C. D. Souza   +6 more
wiley   +1 more source

Providers’ knowledge and perception of xylazine in the unregulated drug supply: a sequential explanatory mixed-methods study

Harm Reduction Journal
Background Xylazine is increasingly prevalent in the unregulated opioid supply in the United States. Exposure to this adulterant can lead to significant harm, including prolonged sedation and necrotic wounds.
Katherine Hill, Rebecca Minahan-Rowley, Emma T. Biegacki, Robert Heimer, Kimberly L. Sue   +4 more
doaj   +1 more source

Effects of paraprobiotic Lactobacillus acidophilus LA‐5 on PANoptosis, oxidative stress and inflammation in acetic acid‐induced ulcerative colitis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Ulcerative colitis (UC) is a relapsing inflammatory bowel disease characterised by oxidative stress, inflammation and regulated cell death of the colonic mucosa. Because live probiotics may cause bacteraemia and sepsis in immunocompromised hosts, non‐viable (paraprobiotic) alternatives have attracted interest.
Adem Yavaş, Ezgi Özkıran, Ecem Akan
wiley   +1 more source

Combined effects of kombucha consumption and aerobic exercise on oxidative stress and metabolic parameters in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Background Kombucha, a fermented tea containing symbiotic bacteria and yeast, and aerobic exercise each confer distinct health benefits, but their combined effects remain poorly understood. This study investigated the combined effects of consuming kombucha fermented for 7 days and performing moderate aerobic exercise on physiological outcomes ...
Jean Carlos Costa Nogueira, Luis Paulo Santos Ribas, Raquel Moura, Jean Ramos Boldori, Alexsander Pedroso Garcia, Kaueli Rodrigues Amaral, Franciele Aline Smaniotto, Tatiana Emanuelle, Cristiane Casagrande Denardin   +8 more
wiley   +1 more source

Effects of oat protein on hematological parameters and metabolism in Wistar rats

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Diets rich in plant‐based proteins are becoming increasingly popular, but the safety of extracted oat (Avena sativa L.) protein in relation to cardiometabolic and endocrine risks remains unexplored. This study evaluated the safety of oat protein by analyzing anthropometric, hematological, biochemical, and histopathological ...
Gabriela Matte Bertoldi, Karine Raquel Uhdich Kleibert, Flávia Alessandra da Silva Räder, Alana Thais Gisch Andres, Luciana Mori Viero, Maria Andréia Inkelmann, José Antonio Gonzalez da Silva, Ivan Ricardo Carvalho, Christiane de Fátima Colet   +8 more
wiley   +1 more source