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Xylazine: A Drug Adulterant of Clinical Concern

Current Pain and Headache Reports
Purpose of review: The opioid epidemic has been responsible for significant morbidity and mortality in the USA and worldwide. As a result, it is essential to recognize the threat these potent drugs can cause when illicitly used. Specifically, introducing
Amber Edinoff, Adam M Kaye, Kevin S. Murnane   +2 more
exaly   +3 more sources

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Evaluation of Xylazine in Camels

Journal of the American Veterinary Medical Association, 1980
SUMMARY When xylazine was given intramuscularly to 12 apparently healthy adult camels (Camelus dromedarius) at the rate of 0.4 mg/kg of body weight, mean values for onset of weak time, down time, and time until recovery were 8.6±1.1, 10.5±0.6, and 150±56.9 minutes, respectively.
P K, Peshin, J M, Nigam, S C, Singh, B A, Robinson   +3 more
openaire   +2 more sources

Xylazine

Reactions Weekly
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Xylazine for sedation of horses

New Zealand Veterinary Journal, 1977
Abstract Extract The introduction of chemical restraint into horse practice brought significant advantages in handling fearful and fractious animals as well as allowing the practitioner to carry out procedures which would normally arouse considerable resistance from the equine patient. Phenothiazine derivatives were widely used for these purposes prior
A M, Holmes, W T, Clark
openaire   +2 more sources

Determination of Xylazine and Its Metabolites by GC–MS in Equine Urine for Doping Analysis

Journal of Pharmaceutical and Biomedical Analysis, 2004
Xylazine and its main metabolites were detected in equine urine after a single-dose intravenous administration of 0.98 and 1.01 mg/kg body weight xylazine, respectively, in two horses, in order to be used for equine doping control routine analysis.
Demetrios Kouretas
exaly   +2 more sources

Effects of ketamine, xylazine, and a combination of ketamine and xylazine in Pekin ducks

American Journal of Veterinary Research, 1989
SUMMARY Effects of ketamine, xylazine, and a combination of ketamine and xylazine were studied in 12 male Pekin ducks (7 to 12 weeks old; mean [± SD] body weight, 3.1 ± 0.3 kg). After venous and arterial catheterization and fixation of a temperature probe in the cloaca, each awake duck was confined, but not restrained, in an open box in a dimly lit ...
J W, Ludders, J, Rode, G S, Mitchell, E V, Nordheim   +3 more
openaire   +2 more sources

Xylazine Pharmacokinetics in Patients Testing Positive for Fentanyl and Xylazine

Clinical Chemistry
Abstract Background The increasing prevalence of xylazine in the illicit drug supply is a growing concern for major health consequences in individuals who use fentanyl mixed with xylazine, but limited data are available regarding the pharmacokinetics of xylazine in humans.
Yanchun Lin, Christopher W Farnsworth, Vahid Azimi, David B Liss, Michael E Mullins, Bridgit O Crews   +5 more
openaire   +2 more sources

Emerging Threat of Xylazine

Clinical Chemistry
Abstract Background The increasing reports of xylazine in clinical and postmortem toxicology necessitate a survey of its clinical impact. This review examines reports of xylazine across the peer-reviewed literature and grey literature (government and public health reports).
Kyla M Jorgenson, Robert A Middleberg, Brandy L Young, Alex J Krotulski, Nicholas E Nacca, Tanzy M Love, Joshua Marvald, Rachel Becker, Marilyn A Huestis, Y Victoria Zhang   +9 more
openaire   +2 more sources

Comparison of lidocaine, xylazine, and lidocaine−xylazine for caudal epidural analgesia in cattle

Veterinary Anaesthesia and Analgesia, 2002
To directly compare the time to onset and duration of analgesia produced by a lidocaine/xylazine combination with that produced by lidocaine and xylazine administered alone in the caudal epidural space of dairy cattle. Design   Prospective randomized experimental study.Nine adult (> 4 years of age) dairy cows (520-613 kg).Caudal epidural analgesia was ...
Tamara L, Grubb, Thomas W, Riebold, Russell O, Crisman, L Dean, Lamb   +3 more
openaire   +2 more sources

Clinical considerations for the management of xylazine overdoses and xylazine‐related wounds

Addiction, 2023
Kimberly L. Sue, Kathryn Hawk
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