Results 241 to 250 of about 157,061 (320)

Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice

Experimental Physiology, EarlyView.
Abstract Elastin insufficiency is associated with structural differences in the large elastic arteries and cerebral artery dysfunction. However, previous studies have not assessed potential sex differences in cerebrovascular function. We measured cerebral blood flow (CBF) using arterial spin labeling MRI at rest and in response to hypercapnia challenge
Abigail E. Cullen, Emily H. Reeve, Nick R. Winder, Grant D. Henson, Nayantara Arora, Thomas Leonhardt, Ainsley Hogan, Sahana Krishna Kumaran, Naly Setthavonsack, Victoria Krajbich, Art Riddle, Benjamin Zimmerman, Nabil J. Alkayed, Martin M. Pike, Randall L. Woltjer, Ashley E. Walker   +15 more
wiley   +1 more source

Psychosocial consequences of xylazine and implications for harm reduction services. [PDF]

Drug Alcohol Depend Rep
Plesons M, Eger WH, Crable EL, Hauschild MH, McElrath CC, Owens C, Forrest DW, Bazzi AR, De Los Santos N, Tookes HE, Bartholomew TS.   +10 more
europepmc   +1 more source

Cardiac‐specific Kv1.1 deficiency alters cardiomyocyte electrophysiology without modifying overall cardiac function or arrhythmia susceptibility

Experimental Physiology, EarlyView.
Abstract The leading cause of epilepsy‐related mortality is sudden unexpected death in epilepsy (SUDEP), resulting from seizure‐induced cardiorespiratory arrest by mechanisms that remain unresolved. Mutations in ion channel genes expressed in both brain and heart represent SUDEP risk factors because they can disrupt neural and cardiac rhythms ...
Kelsey Halvorson, Man Si, Krystle Trosclair, Ellen Aughenbaugh, Maxine Parkinson, Nicole M. Gautier‐Hall, Megan Watts, Frederica Kizek, Md. Shenuarin Bhuiyan, Paari Dominic, Kathryn A. Hamilton, Edward Glasscock   +11 more
wiley   +1 more source

Infectious Diseases in People Who Use Drugs Introduction. [PDF]

Open Forum Infect Dis
Marks L.
europepmc   +1 more source

The xylazine-fentanyl nexus: A public health emergency. [PDF]

SAGE Open Med
Sandhu KS, Kumar S, Garg K, Aggarwal K, Tiwwary M, Perry G, Bansal V, Jain R.   +7 more
europepmc   +1 more source

Do auditory deviants evoke cortical state changes under anaesthesia? A proof‐of‐concept study

Experimental Physiology, EarlyView.
Abstract Context‐dependent sensory processing within the predictive coding framework relies on detecting mismatches between incoming stimuli and internal predictive models. Sensory deviants elicit prediction errors, seen as enhanced neural responses, that update these models and influence attention and behaviour.
Laura H Bohórquez, Manuel S Malmierca, Adam Hockley   +2 more
wiley   +1 more source

Echocardiographic assessment of left ventricular function in mules under general anesthesia induced with a high-dose xylazine-based protocol. [PDF]

Vet World
Puangsubsin P, Isawirodom A, Rungsri P, Satumay N, Laikul A, Cherdchutham W.   +5 more
europepmc   +1 more source

Exercise intensity‐dependent cardiac telocyte expansion is associated with physiological growth despite JAK/STAT pathway inactivity in male Wistar rats

Experimental Physiology, EarlyView.
Abstract While exercise induces physiological cardiac growth, the underlying cellular mechanisms remain incompletely understood. This study investigated the role of cardiac telocytes (TCs) and the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) pathway in mediating exercise intensity‐dependent cardiac adaptation.
Mahboobeh Borjian Fard, Siroos Choobineh, Rahman Soori, Zohreh Mazaheri   +3 more
wiley   +1 more source

Emergence of Medetomidine in the Unregulated Drug Supply and Its Association With Hallucinogenic Effects. [PDF]

Drug Alcohol Rev
Sibley AL, Bedard ML, Tobias S, Chidgey BA, Phillips IG, Bell A, Dasgupta N.   +6 more
europepmc   +1 more source

Early life stress and disruption of the ageing trajectory in female rats: Insights into the origins and mechanisms underlying the risk of hypertension

Experimental Physiology, EarlyView.
Abstract Menopause increases the risk of hypertension in women, yet the factors contributing to this important change remain unclear. Because early life stress has persistent and sex‐specific consequences on health, we hypothesized that ageing reveals the latent effects of neonatal maternal separation (NMS) on cardiovascular homeostasis in female rats.
Danuzia Ambrozio‐Marques, Loralie Mei Guay, Alicia A. Koogler, Tim D. Ostrowski, Aline M. Arlindo de Souza, Kathryn Sandberg, Richard Kinkead   +6 more
wiley   +1 more source