Results 261 to 270 of about 157,061 (320)

Anesthesia blocks the cardiovascular response to baroreceptor unloading in rats. [PDF]

Function (Oxf)
Nieman ML, Sakthivel S, Mackenzie B, Lorenz JN.   +3 more
europepmc   +1 more source

Beyond Myiasis: Understanding Environmental Factors, Maggots, and Infection Risks in Xylazine-Associated Wounds. [PDF]

Cureus
Chang AH, Oh K, Patel S, Walchak A.
europepmc   +1 more source

Biochemical Identification and Clinical Description of Medetomidine Exposure in People Who Use Fentanyl in Philadelphia, PA. [PDF]

Int J Mol Sci
Durney P, Kahoud JL, Warrick-Stone T, Montesi M, Carter M, Butt S, Mencia AM, Omoregie L, Shah M, Bloomfield M, Tomasko N, Jaffe R, Herens A, Korn WR, Alexander K, Stickle D, Goodstein D, Weinstein LC, London KS.   +18 more
europepmc   +1 more source

A Systematic Review of the Effects of N-Methyl-D-Aspartate Receptor Antagonists on Pancreatic Islets.

Neuroendocrinology
Wong S, Le GH, Uhlig J, Yang E, Dri CE, Rosenblat JD, Mansur RB, McIntyre RS.   +7 more
europepmc   +1 more source

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Xylazine Pharmacokinetics in Patients Testing Positive for Fentanyl and Xylazine

Clinical Chemistry
Abstract Background The increasing prevalence of xylazine in the illicit drug supply is a growing concern for major health consequences in individuals who use fentanyl mixed with xylazine, but limited data are available regarding the pharmacokinetics of xylazine in humans.
Yanchun Lin, Christopher W Farnsworth, Vahid Azimi, David B Liss, Michael E Mullins, Bridgit O Crews   +5 more
openaire   +3 more sources

Xylazine Adulteration of the Heroin–Fentanyl Drug Supply

Annals of Internal Medicine, 2023
Xylazine is an animal sedative, approved by the U.S. Food and Drug Administration, that is commonly used in veterinary medicine and is not approved for human use.
Joseph D’Orazio, Lewis S. Nelson, Jeanmarie Perrone, Rachel S. Wightman, R. Haroz   +4 more
semanticscholar   +1 more source

Xylazine and xylazine-ketamine in dogs

American Journal of Veterinary Research, 1986
SUMMARY The cardiopulmonary consequences of iv administered xylazine (1.0 mg/kg) followed by ketamine (10 mg/kg) were evaluated in 12 dogs. Xylazine caused significant decreases in heart rate, cardiac output, left ventricular work, breathing rate, minute ventilation, physiologic dead space, oxygen transport, mixed venous partial pressure of oxygen, and
S C, Haskins, J D, Patz, T B, Farver
openaire   +2 more sources

Comparative analgesia of xylazine, xylazine/morphine, xylazine/butorphanol, and xylazine/nalbuphine in the horse, using dental dolorimetry

American Journal of Veterinary Research, 1987
SUMMARY Xylazine, morphine, butorphanol, and nalbuphine were evaluated in 5 adult male horses, using dental dolorimetry. Comparisons were made at 30, 60, and 100 minutes after iv drug administration. Peak analgesia and the time to develop peak analgesia also were compared. Xylazine induced a marked increase in the tooth pulp pain threshold measurements
D B, Brunson, L J, Majors
openaire   +2 more sources

Recognition and Treatment of Wounds in Persons Using Xylazine: A Case Report From New Haven, Connecticut.

Journal of addiction medicine, 2023
BACKGROUND Xylazine is an α2-adrenergic agonist that is commonly used as a veterinary tranquilizer and is increasingly present in the unregulated US drug supply since at least 2019.
A. Dowton, Molly Doernberg, Erica Heiman, Peter J Barelli, M. Golden, He Wang, J. Leventhal, K. Morford, Kimberly L Sue   +8 more
semanticscholar   +1 more source

Xylazine suppresses fentanyl consumption during self-administration and induces a unique sex-specific withdrawal syndrome that is not altered by naloxone in rats.

Experimental and clinical psychopharmacology, 2023
Prescription and illicit opioid use are a public health crisis, with the landscape shifting to fentanyl use. Since fentanyl is 100-fold more potent than morphine, its use is associated with a higher risk of fatal overdose that can be remediated through ...
Shailesh N. Khatri, Safiyah M. Sadek, Percell T. Kendrick, Emma O. Bondy, Mei Hong, Sally Pauss, Dan Luo, T. Prisinzano, K. Dunn, J. Marusich, Joshua S. Beckmann, T. Hinds, C. Gipson   +12 more
semanticscholar   +1 more source