Results 61 to 70 of about 150,572 (297)

Reported xylazine exposure highly associated with overdose outcomes in a rapid community assessment among people who inject drugs in Baltimore

Harm Reduction Journal
Background Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes. Methods We conducted a rapid
Danielle German, Becky Genberg, Olivia Sugarman, Brendon Saloner, Anne Sawyer, Jennifer L. Glick, Molly Gribbin, Colin Flynn   +7 more
doaj   +1 more source

Wastewater Surveillance for Xylazine in Kentucky

AJPM Focus
Introduction: In the U.S., xylazine, the veterinary non-opioid sedative, has emerged as a major threat to people who use illicitly manufactured fentanyl and other drugs.
Chris Delcher, PhD, Dana Quesinberry, JD, DrPH, Soroosh Torabi, PhD, Scott Berry, PhD, James W. Keck, MD, Abhya Rani, Bikram Subedi, PhD   +6 more
doaj   +1 more source

Comparing and Contrasting Knowledge on Mules and Hinnies as a Tool to Comprehend Their Behavior and Improve Their Welfare. [PDF]

, 2019
Mules and hinnies are the hybrids between donkeys (Equus asinus) and horses (Equus caballus). For centuries, mankind has used them for agrarian purposes, the military, or recreation.
Ali, Ahmed, Heleski, Camie, McLean, Amy, Navas González, Francisco Javier, Varnum, Angela   +4 more
core   +1 more source

Characterization of a reproducible model of fracture healing in mice using an open femoral osteotomy [PDF]

, 2020
Purpose: The classic fracture model, described by Bonnarens and Einhorn in 1984, enlists a blunt guillotine to generate a closed fracture in a pre-stabilized rodent femur.
Akkus, O., Anderson, J.M., Collier, C.D., Din, E.S., Greenfield, E.M., Hausman, B.S., Zulqadar, S.H.   +6 more
core   +1 more source

β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma

Advanced Science, EarlyView.
β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto, Deborah Silverman, Tongxin Xie, Shamima Akhter, Nicole R. Vaughn, Adewale Adebayo, Kala Chand Debnath, Shorook Naara, Shajedul Islam, Erik Knutsen, Emily Lorin Ashkin, Simone Anfossi, Sara Leahey, Patrick Hwu, Sebastien Talbot, Erica K Sloan, Robert Saddawi‐Konefka, Roberto Rangel, Jeffrey N. Myers, George A. Calin, Moran Amit   +20 more
wiley   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

434 Xylazine quantitation in Puerto Rican drug users and cardiotoxic protein markers profile expression analysis

Journal of Clinical and Translational Science
Objectives/Goals: Our research addresses critical gaps by examining the prevalence, blood concentrations, and health implications of xylazine abuse, with a focus on its cardiotoxic effects. We aim to map the geographic distribution of xylazine use across
Luz Silva, Claudia Amaya, Valerie Wonja, Sylvette Ayala   +3 more
doaj   +1 more source

Phospholipid Adsorption Polymeric Materials for Detection of Xylazine and Metabolite in Blood and Urine

International Journal of Polymer Science, 2016
Polymers have been used in different areas. Recently, polymeric material is favored in analytical area due to its high performance and high consistency, which was used in sample pretreatment in this study.
Xue Gao, Hao Guo, Chaokang Gu
doaj   +1 more source

Features of reproduction and assisted reproduction in the white (Ceratotherium simum) and black (Diceros bicornis) rhinoceros [PDF]

, 2015
Despite the worldwide increase of rhinoceros calf numbers, the growth of the population of white and black rhinoceros is slowing down mainly due to anthropogenic causes, such as poaching and habitat loss.
Govaere, Jan, Van Soom, Ann, van Zijl Langhout, M, Ververs, Cyrillus   +3 more
core  

Interpreting Neuroendocrine Hormones, Corticosterone, and Blood Glucose to Assess the Wellbeing of Anesthetized Rats during Euthanasia [PDF]

, 2018
Current recommendations for assessing animal wellbeing during euthanasia suggest that measuring neuroendocrine hormones-such as ACTH, noradrenaline, and adrenaline-is preferable to measuring corticosterone and blood glucose because of the sensitivity of ...
Hickman, Debra L.
core   +1 more source