Results 41 to 50 of about 119,267 (282)

Qualitative and quantitative characteristics of xylazine-associated deaths detected using a post-mortem toxicology testing program

, 2023
The United States drug overdose crisis continues to evolve. Xylazine has been increasingly identified as an adulterant in illicit opioid supplies. The incorporation of novel adulterants, like xylazine, into the illicit drug supply adds complexity to post-
Gabrielle K. Stroh-Steiner (17627146), Varun Vohra (1287102), Prentiss Jones (17627149)   +2 more
core   +1 more source

Single‐Cell Dissection of Microglial Dysfunction in Diabetes‐Associated Neurodegenerative Vulnerability

Advanced Science, EarlyView.
Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang, Tsz Kwan Yau, Joyce Tse, Tsz Ho Li, Dongjie Hu, Yong Juan Zhao, Ting‐Fung Chan   +6 more
wiley   +1 more source

TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non‐Syndromic Hearing Loss

Advanced Science, EarlyView.
TECTB is a non‐collagenous protein of the tectorial membrane – an extracellular matrix of the cochlea. This study identifies dominant missense variants in TECTB linked to human hereditary deafness in two unrelated families. Genetically engineered mice homozygous for one of the variants are profoundly deaf, whereas heterozygous mice have normal hearing ...
Evan B. Hale, Barbara Vona, Richard J. Goodyear, Richard T. Osgood, Jun Shen, Sami S. Amr, Karen Mojica, Michaela A. H. Hofrichter, Jörg Schröder, Sophie Flandin, Paul Gratias, Ricardo Vera‐Monroy, Katherine Callahan, Kerry L. Gudlewski, Rolen Quadros, Masato Ohtsuka, JoAnn McGee, Edward J. Walsh, Cynthia C. Morton, Thomas Haaf, Channabasavaiah Gurumurthy, James E. Saunders, Guy P. Richardson, Artur A. Indzhykulian   +23 more
wiley   +1 more source

The effect of vitamin C at varying times on physiological parameters in rabbits after xylazine anaesthesia [PDF]

Veterinaria Italiana, 2011
The effects of vitamin C administration at varying time intervals on rectal temperature, respiratory rates, heart rates and sleeping time following xylazine anaesthesia was evaluated in rabbits.
Godwin Onyeamaechi Egwu, Gideon Dauda Mshelia, Saka Sanni, Patrick Azubuike Onyeyili, Gladys Taiwo Adeyanju   +4 more
doaj  

Interleukin‐1α Mediates Pancreatic Fibroblast Activation, Regulates Immune Cell Recruitment and Fibrosis in Acute and Chronic Pancreatitis

Advanced Science, EarlyView.
During pancreatitis, IL‐1α is released from necrotic acinar cells. In response to IL‐1α, pancreatic fibroblasts release chemokines and cytokines that regulate the recruitment of immune cells to the damaged organ. Furthermore, IL‐1α primes fibroblasts, resulting in increased tissue fibrosis during chronic pancreatitis.
Hala Mazloum, Shenja Buchholz, Hanna Schifter, Sabine Ameling, Leif Steil, Ben Lewin Becker, Elke Hammer, Georg Homuth, Uwe Völker, Barbara M. Bröker, Lukas Zierke, Frank Ulrich Weiss, Juliane Glaubitz, Matthias Sendler   +13 more
wiley   +1 more source

THE ELECTROM YOGRAPHIC EFFECTS OF TOLAZOLINE AFTER XYLAZINE TREATMENT ON THE GIT OF GOATS [PDF]

Assiut Veterinary Medical Journal, 1991
The electromyographic effects of tolazoline (1mg/Lb. BWt., 1/V) after xylazine (0.05 mg/Lb. BWt., 1/V) administration on the rumen, reticulum, abomasum and duodenum were evaluated in 6 goats.
M.M. KASSEM, D.R. NELSON, H.A. YOUSSEF
doaj   +1 more source

Smartphone‐Guided Visible Light Modulation of RSNOs for Antimicrobial Activity via Controlled Nitric Oxide Release

Advanced Science, EarlyView.
A light‐activated catheter insert combines antimicrobial blue light with nitric oxide release to generate complementary oxidative and nitrosative stress, producing potent broad‐spectrum antimicrobial activity. The approach achieves greater than 4‐log reductions in bacterial and fungal viability and significantly reduces Staphylococcus aureus ...
Alexander Bruckmann, Adam Brooks Goodman, Myddelton C. Parker, Mark Garren, Ji Eun Park, Chad Schmiedt, Hitesh Handa, Elizabeth J. Brisbois   +7 more
wiley   +1 more source

The metabolism of xylazine in rats

, 2019
The biotransformation of xylazine, a widly used animal tranquilizer, was investigated in rats. After administration of xylazine, the existence of 2,6-dimethylphenylisothiocyanate, 2,6-dimenthyl-4-hydroxy-aniline and p-hydroxy-xylazine in urine was ...
박혜영
core   +1 more source

‘Tranq’: perceptions of xylazine and harm reduction practices among people receiving treatment for substance use disorders

Harm Reduction Journal
Background Xylazine, commonly known as ‘Tranq,’ is a veterinary tranquilizer that is increasingly found in the recreational opioid supply, complicating the user experience.
Aaron Salwan, KariLynn Dowling-McClay, Daniel Greer, Ali AlAli, Bill Brooks   +4 more
doaj   +1 more source

Co‐activation of Selective Nicotinic Acetylcholine Receptor Subtypes Is Required for Neuroprotection against Alzheimer's Disease

Advanced Science, EarlyView.
ABSTRACT Beta‐amyloid peptide (Aβ)‐induced suppression of hippocampal GABAergic interneuron activity drives hyperexcitability, amyloid pathology, and cognitive impairment in Alzheimer's disease (AD), suggesting that enhancing hippocampal inhibition may be protective.
Rahmi Lee, Gayeon Kim, Ellison R. Black, Seonil Kim   +3 more
wiley   +1 more source