Results 41 to 50 of about 110,075 (237)

Bioinspired Passive Flow Routing to Mitigate Thrombosis in Prosthetic Heart Valves and Cardiovascular Devices

Advanced Science, EarlyView.
Bioinspired passive flow routing mitigates thrombosis in cardiovascular devices by redirecting a small fraction of forward flow into stagnation‐prone regions. Inspired by avian alula and aircraft slat mechanisms, strategically placed routing channels restore washout around mechanical heart valves, reducing low‐shear exposure by four orders of magnitude
Yevgeniy Kreinin, Mark Epshtein, Yahel Talmon, Tirosh Mekler, Itay Or, Mahli Raad, Gil Bolotin, Josué Sznitman, Netanel Korin   +8 more
wiley   +1 more source

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

Xylazine awareness and attitudes among people who use drugs in Ohio, 2023–2024

Harm Reduction Journal
Background The prevalence of xylazine, a non-opioid tranquilizer not for human consumption, in illicitly manufactured fentanyl is increasing in the United States. However, little is known about xylazine awareness and attitudes among people who use drugs.
Nichole L. Michaels, Saroj Bista, Ashley Short Mejia, Hannah Hays, Gary A. Smith   +4 more
doaj   +1 more source

Xylazine awareness, desire, use and exposure: Preliminary findings from the Rhode Island community-based drug checking cohort study

Drug and Alcohol Dependence Reports
Background: Xylazine is an ⍺2 adrenergic receptor agonist and a veterinary sedative that can cause severe health complications yet interventions to detect and treat human exposure remain underdeveloped.
Ju Nyeong Park, Rachel Serafinski, Merci Ujeneza, Michelle McKenzie, Jessica Tardif, Alex J. Krotulski, Adina Badea, Elyse R. Grossman, Traci C. Green   +8 more
doaj   +1 more source

Neuropeptide Y—Graphene Oxide Complexes Inhibit Amygdala NPY‐Receptor Expressing Glutamatergic Pathways and Selectively Remove Aversive Memory In Vivo

Advanced Science, EarlyView.
A graphene oxide nanocarrier presents neuropeptide Y specifically to NPY receptor‐expressing pathways in the amygdala, whose activation selectively suppresses aversive memory formation, without modulating anxiety responses. This circuit‐restricted drug release strategy may impact future design of neuropsychiatric therapies with limited off‐target ...
Elisa Pati, Audrey Franceschi Biagioni, Raffaele Casani, Luis M. Arellano, Tommaso Battisti, Gloria Garcia‐Ortega, Neus Lozano, Alberto Bianco, Kostas Kostarelos, Laura Ballerini, Giada Cellot   +10 more
wiley   +1 more source

Comparison of Seda‐Block and Xylazine–Ketamine Anaesthesia for Metacarpal and Radioulnar Osteosynthesis in Calves

Veterinary Medicine and Science
Objective To evaluate the clinical feasibility and anaesthetic efficacy of a combined Bier block and brachial plexus block administered with xylazine sedation (seda‐block) for metacarpal and radioulnar osteosynthesis in neonatal calves, and to compare ...
Mümin Gökhan Şenocak, Çağlar Özkalipçi, Taner Arslan, Yasemin Akçora, Tuğçe Kartal, Cüneyt Türkmen, Büşra Baykal, Sıtkıcan Okur, Ayşe Gölgeli Bedir, Ferda Turgut, Yakup Kocaman, Ömer Tarık Orhun, Uğur Ersöz, Elif Doğan, Latif Emrah Yanmaz   +14 more
doaj   +1 more source

Neurobehavioral Impacts of Xylazine and Piracetam Interaction on NADH Oxidase in the Rat Brain

Kufa Journal for Veterinary Medical Sciences
      In the present study, the effects of different doses of xylazine combined with piracetam were investigated through different behavioral experiments. Xylazine is alpha 2 adrenergic agonist a veterinary sedative, and analgesic agent.
Shaker M. Kermasha, Mohammad T. Naqi Al-Bayati   +1 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source

Reported xylazine exposure highly associated with overdose outcomes in a rapid community assessment among people who inject drugs in Baltimore

Harm Reduction Journal
Background Addressing xylazine harms are now a critical harm reduction priority, but relatively little epidemiological information exists to determine prevalence, magnitude, and correlates of xylazine use or related outcomes. Methods We conducted a rapid
Danielle German, Becky Genberg, Olivia Sugarman, Brendon Saloner, Anne Sawyer, Jennifer L. Glick, Molly Gribbin, Colin Flynn   +7 more
doaj   +1 more source

ICOS‐ImmunoPET Monitors T Cell Activation After Combination Immune Checkpoint Blockade in a Mouse Model of Melanoma Brain Metastasis

Advanced Science, EarlyView.
ICOS‐immunoPET noninvasively visualizes activated T cells in melanoma brain metastases following combined anti‐PD‐1/anti‐CTLA‐4 therapy. Clinical translation of this imaging approach may improve patient stratification and treatment monitoring and serve as a quantitative imaging endpoint to support immunotherapy development and clinical trials in brain ...
Renesmee C. Kuo, Rohit Verma, Sydney C. Nagy, Mausam Kalita, Samuel Aubert, Josué Ballesteros‐Álvarez, Pedro Machado Almeida, Hannes Vogel, Israt S. Alam, Michael Lim, Michelle L. James   +10 more
wiley   +1 more source