Results 31 to 40 of about 119,267 (282)
Advanced Materials, EarlyView.Synthesis and screening of a polymer library produced a versatile and inhalable mRNA vehicle for the lungs (P81). Compared to a published LNP, P81 provides increased delivery efficacy, achieving widespread expression in broad cell types, with no toxicity.
Pramodkumar EK +36 more
wiley +1 more source
Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the Central Nervous System of Rats. [PDF]
PLoS ONE, 2016 Xylazine is a potent analgesic extensively used in veterinary and animal experimentation. Evidence exists that the analgesic effect can be inhibited using adenosine 5'-monophosphate activated protein kinase (AMPK) inhibitors.
Xing-Xing Shi +7 more
doaj +1 more source
Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation
Advanced Materials Technologies, EarlyView.Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching +9 more
wiley +1 more source
Revue d’Elevage et de Médecine Vétérinaire des Pays Tropicaux, 2001 The project DGEG (Game Farming Development in Gabon) aims at establishing technical references on farming of wild species, among which are the brush-tailed porcupine (Atherurus africanus) and the giant rat (Cricetomys emini). In their daily practice, the
D. Edderai +3 more
doaj +1 more source
Innate Immunocompetent hiPSC‐Derived Neurospheroids Capture Early CNS Responses to rAAV
Advanced Science, EarlyView.Knowledge of human CNS immune responses to AAV‐based gene therapies remains limited due to the lack of immune‐competent human models. Here, a hiPSC‐derived 3D neuroimmune platform integrating neurospheroids and microglia is established using stirred‐tank bioreactors.
Catarina M. Gomes +14 more
wiley +1 more source
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Harm Reduction Journal, 2023 Introduction Xylazine, an α2-adrenoceptor agonist sedative commonly used in veterinary medicine, is not approved for human use. Nevertheless, xylazine-involved overdose rates have surged in recent years, fueled by an increasingly toxic and synthetic ...
David T. Zhu
doaj +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
Journal of Pharmacological Sciences, 2009 Xylazine is an α2-adrenergic agonist extensively used in veterinary medicine and animal experimentation for producing antinociception, sedation, and muscle relaxation.
Thiago Roberto Lima Romero +1 more
doaj +1 more source
THE CLINICAL EVALUATION OF THE EFFECT OF XYLAZINE IN PREGNANT BUFFALOEs AND CATTLE [PDF]
Basrah Journal of Veterinary Research, 2007 The object of this study was to investigate the effect of xylazine administration at dose of (0.05 mg/kg BW) intravenously in late pregnancy of buffaloes and cattle.
M. J. Eesa
doaj +1 more source