Results 21 to 30 of about 150,572 (297)

Xylazine Activates Adenosine Monophosphate-Activated Protein Kinase Pathway in the Central Nervous System of Rats. [PDF]

open access: yesPLoS ONE, 2016
Xylazine is a potent analgesic extensively used in veterinary and animal experimentation. Evidence exists that the analgesic effect can be inhibited using adenosine 5'-monophosphate activated protein kinase (AMPK) inhibitors.
Xing-Xing Shi   +7 more
doaj   +1 more source

Sedative and antinociceptive effects of different combinations of detomidine and methadone in standing horses [PDF]

open access: yes, 2017
Objective To evaluate intravenous (IV) detomidine with methadone in horses to identify a combination which provides sedation and antinociception without adverse effects. Study design Randomized, placebo-controlled, blinded, crossover.
Crosignani, N   +6 more
core   +2 more sources

Xylazine prevalence and concentration in the Los Angeles fentanyl market, 2023–2025

open access: yesDrug and Alcohol Dependence Reports
Background: The veterinary sedative xylazine has been mostly described on the East Coast—yet early reports indicate that it is now arriving to West Coast fentanyl markets.
Joseph Friedman   +10 more
doaj   +1 more source

THE CLINICAL EVALUATION OF THE EFFECT OF XYLAZINE IN PREGNANT BUFFALOEs AND CATTLE [PDF]

open access: yesBasrah Journal of Veterinary Research, 2007
The object of this study was to investigate the effect of xylazine administration at dose of (0.05 mg/kg BW) intravenously in late pregnancy of buffaloes and cattle.
M. J. Eesa
doaj   +1 more source

Physics of brain dynamics: Fokker-Planck analysis reveals changes in EEG delta-theta interactions in anaesthesia [PDF]

open access: yes, 2009
We use drift and diffusion coefficients to reveal interactions between different oscillatory processes underlying a complex signal and apply the method to EEG delta and theta frequencies in the brain.
A Bahraminasab   +12 more
core   +1 more source

Involvement of ATP-Sensitive K+ Channels in the Peripheral Antinociceptive Effect Induced by the α2-Adrenoceptor Agonist Xylazine

open access: yesJournal of Pharmacological Sciences, 2009
Xylazine is an α2-adrenergic agonist extensively used in veterinary medicine and animal experimentation for producing antinociception, sedation, and muscle relaxation.
Thiago Roberto Lima Romero   +1 more
doaj   +1 more source

Reading out a spatiotemporal population code by imaging neighbouring parallel fibre axons in vivo. [PDF]

open access: yes, 2015
The spatiotemporal pattern of synaptic inputs to the dendritic tree is crucial for synaptic integration and plasticity. However, it is not known if input patterns driven by sensory stimuli are structured or random.
Häusser, M, Wilms, CD
core   +1 more source

Targeting Post‐Irradiation Thyroid Dysfunction: Electrospun Scaffolds As A Dual‐Action Approach for Antioxidant and Immune Modulation

open access: yesAdvanced Healthcare Materials, EarlyView.
Radiation‐induced hypothyroidism follows head and neck radiotherapy due to oxidative stress and inflammation. Electrospun polycaprolactone scaffolds containing adenosine have potential to modulate thyroid repair. Scaffolds enhance thyrocyte proliferation, antioxidant enzymes glutathione peroxidase and catalase, reduce senescence and apoptosis markers ...
Maria Heim   +5 more
wiley   +1 more source

Public health impact and harm reduction implications of xylazine-involved overdoses: a narrative review

open access: yesHarm Reduction Journal, 2023
Introduction Xylazine, an α2-adrenoceptor agonist sedative commonly used in veterinary medicine, is not approved for human use. Nevertheless, xylazine-involved overdose rates have surged in recent years, fueled by an increasingly toxic and synthetic ...
David T. Zhu
doaj   +1 more source

Simultaneous multiplane imaging with reverberation multiphoton microscopy [PDF]

open access: yes, 2019
Multiphoton microscopy (MPM) has gained enormous popularity over the years for its capacity to provide high resolution images from deep within scattering samples1.
Beaulieu, Devin R.   +4 more
core   +1 more source

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