Toxics, 2023 Xylazine abuse is emerging globally, while the identification of xylazine lethal cases poses a great challenge in clinical and forensic practice. The non-specific symptoms delay the diagnosis and treatment of xylazine poisoning, the pathological changes ...
Shuquan Zhao, Zhang Youyou
exaly +3 more sources
Comparison of Seda‐Block and Xylazine–Ketamine Anaesthesia for Metacarpal and Radioulnar Osteosynthesis in Calves [PDF]
Veterinary Medicine and ScienceObjective To evaluate the clinical feasibility and anaesthetic efficacy of a combined Bier block and brachial plexus block administered with xylazine sedation (seda‐block) for metacarpal and radioulnar osteosynthesis in neonatal calves, and to compare ...
Mümin Gökhan Şenocak +14 more
doaj +2 more sources
Navigating an unpredictable supply: lived experiences of xylazine exposure among people who use drugs [PDF]
Harm Reduction JournalBackground As xylazine-adulterated opioids become more prevalent in the U.S., people who use drugs (PWUD) face growing risks from sedation, withdrawal, and wounds.
Raagini Jawa +12 more
doaj +2 more sources
Zeroing in on xylazine - a mixed methods study to explore correlates of reported xylazine use and educational gaps among people who use drugs [PDF]
Harm Reduction JournalBackground Xylazine prevalence has surged in the unregulated fentanyl supply across the United States. In efforts to inform education initiatives for people who use drugs, this study aimed to identify factors associated with reported xylazine use and ...
Katherine Hill +4 more
doaj +2 more sources
Unmasking a neurotoxic duo: a comprehensive overview of fentanyl–xylazine crosstalk in kinase pathways [PDF]
Frontiers in Cellular NeuroscienceIntroductionFentanyl is the main cause of the US overdose crisis, responsible for over half of overdose deaths, totaling around 75,000 lives each year. The contamination of the illegal drug supply with xylazine has been linked to an increase in overdose ...
Sally N. Pauss +5 more
doaj +2 more sources
Xylazine in Ohio: Insights from individuals with criminal legal system involvement and a history of illicit stimulant use [PDF]
Drug and Alcohol Dependence ReportsBackground: Xylazine, a non-opioid sedative not approved for human use, poses serious health risks. It is primarily found in illicitly manufactured fentanyl, but xylazine-fentanyl combinations also appear as illicit stimulant adulterants.
Bridget Duffy +4 more
doaj +2 more sources
Addiction NeuroscienceXylazine is in the unregulated drug supply at increasing rates, usually combined with fentanyl, necessitating understanding of its pharmacology. Despite commentary from politicians, and public health officials, it is unknown how xylazine impacts naloxone
Zoe A McElligott +2 more
exaly +3 more sources
Crack/cocaine use to manage xylazine exposure in fentanyl in Connecticut: findings from a convergent mixed methods study [PDF]
Harm Reduction JournalBackground In the context of the fourth wave of the opioid overdose crisis, defined by fentanyl and stimulant co-use, we aimed to explore if there might be a relationship between exposure to xylazine in the fentanyl supply and patterns of crack/cocaine ...
Katherine Hill +10 more
doaj +2 more sources
Xylazine – from a veterinary medicine to a deadly drug of abuse [PDF]
Farmacja Polska, 2023 Xylazine, a potent α2-adrenergic receptor agonist, is used exclusively in veterinary medicine for its sedative, analgesic and muscle-relaxant effects. The drug is used in dogs, cats, rabbits, horses, cattle, sheep, goats, cervids, birds and laboratory ...
Jolanta Barbara Zawilska
doaj +1 more source
Drug and Alcohol Dependence Reports, 2022 Background: Xylazine is an animal tranquilizer increasingly detected in those who have died of an opioid overdose in Philadelphia, PA and elsewhere. Despite an increasing presence of xylazine in the local fentanyl/heroin drug market and its association ...
Megan K. Reed +5 more
doaj +1 more source