Results 131 to 140 of about 202,867 (255)

A Global Analysis of Y-STR INRA189 Polymorphism in Chinese Domestic Yak Breeds/Populations. [PDF]

Animals (Basel), 2020
Ma Z, Xia X, Chen S, Bai M, Lei C, Han J.   +5 more
europepmc   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

[Polymorphism and Mutation Rate of 20 Rapidly Mutating Y-Chromosomal Short Tandem Repeats in Chinese Han Population of Sichuan Province]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Zhang SL, Jian H, Wang Q, Wang W, Ding YJ, Zhang X, Xu DD, Du B, Jin B.   +8 more
europepmc   +1 more source

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

Rapid forensic ancestry inference in selected Northeast Asian populations: a Y-STR based attention-based ensemble framework for initial investigation guidance. [PDF]

Front Genet
Koo KC.
europepmc   +1 more source

OCIAD2 Stabilizes Integrin β1 Signaling Through SNX17‐Mediated Endosomal Recycling to Lipid Rafts and Modulates Cisplatin Response in HNSCC

Advanced Science, EarlyView.
This study identifies OCIAD2 as a critical regulator of cisplatin resistance in HNSCC. Mechanistically, OCIAD2 stabilizes integrin β1 through a direct physical interaction and facilitates its SNX17‐dependent endosomal recycling to lipid raft microdomains. Targeting OCIAD2 disrupts integrin β1 trafficking and significantly enhances cisplatin sensitivity,
Li Cui, Shanshan Si, Min Ye, Pei Lin, Meiyan Zou, Yunfan Lin, Xu Chen, Bing Guo, Wenjuan Sun, Xinyuan Zhao   +9 more
wiley   +1 more source

Considerations on expanding criminal offender DNA databases with Y-STR profiles. [PDF]

J Law Biosci
Ralf A, Zieger M, Kayser M.
europepmc   +1 more source

An Insulin‐Exosome‐TNFAIP8 Axis Drives Stromal Fibrosis and Therapeutic Resistance in Pancreatic Cancer

Advanced Science, EarlyView.
In pancreatic ductal adenocarcinoma (PDAC), insulin is associated with activation of PI3K/AKT–RAB3A signaling and enhanced secretion of TNFAIP8‐enriched exosomes from tumor cells. Uptake of these exosomes by fibroblasts is linked to TRIM21‐dependent STAT1 degradation and the emergence of myofibroblastic CAF–associated features, accompanied by increased
Zhenyu Li, Li Chen, Tao Wang, Haiyang Jiang, Huijuan Wang, Mengyu Li, Guanpeng Xie, Chunhua Xi, Han Yan, Chunhui Lu, Chenchen Li, Hanyu Zhu, Feihu Sun, Lingdi Yin, Jun Yu, Yi Miao   +15 more
wiley   +1 more source

Haplotype diversity of 17 Y-STR in the Iranian population. [PDF]

BMC Genomics
Eskandarion MR, Tabrizi AA, Shirkoohi R, Raoofian R, Naji M, Pazhoomand R, Salari H, Samadirad B, Sabouri A, Zohour MM, Namazi H, Farhadi P, Baratieh Z, Sayyari M, Dadgarmoghaddam M, Safdarian E, Nikbakht A, Golshan F, Baybordi F, Madhaji E, ShohodiFar S, Tabasi M, Mohebbi R.   +22 more
europepmc   +1 more source

Aplicação de Y -STRs em casos forenses

, 2002
Nos últimos anos, o interesse no estudo do cromossoma Y tem aumentado continuamente, como aplicação forense e ao nível do estudo populacional. Os Y-STRs foram introduzidos no Serviço de Genética Forense para resolução de casos complexos, essencialmente de casos com ausência de pretenso pai.Inicialmente foi efectuado um estudo do haplotipo mínimo ...
Vieira Da Silva, Cláudia, Viriato, Luís, Cruz, Carla, Lucas, Isabel, Ribeiro, Teresa   +4 more
openaire   +1 more source