Results 41 to 50 of about 202,867 (255)

Genetic Polymorphisms of 27 Y-STR Loci in Dongxiang Population of Gansu Province#br# [PDF]

Fayixue Zazhi, 2018
Objective To investigate the genetic polymorphisms of 27 Y-STR in Dongxiang population of Gansu province, and to explore the population genetic relationship and the value of forensic application.
LIU Ya-ju, GUO Li-hong, LI Jin, et al
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Y-LineageTracker: a high-throughput analysis framework for Y-chromosomal next-generation sequencing data

BMC Bioinformatics, 2021
Background Y-chromosome DNA (Y-DNA) has been used for tracing paternal lineages and offers a clear path from an individual to a known, or likely, direct paternal ancestor. The advance of next-generation sequencing (NGS) technologies increasingly improves
Hao Chen, Yan Lu, Dongsheng Lu, Shuhua Xu   +3 more
doaj   +1 more source

Y-STR INRA189 polymorphisms in Chinese yak breeds

Genetics and Molecular Research, 2015
To further explore Y-STR INRA189 polymorphisms in the yak, and to determine the genetic differences among yak breeds, genotyping analysis of INRA189 in 102 male yak individuals from three yak breeds in Qinghai Province of China was performed. Genotyping revealed the presence of four alleles, with sizes of 149, 155, 157, and 159 bp, respectively.
Z J, Ma, S M, Chen, Y G, Sun, Y L, Xi, R Z, Li, J T, Xu, C Z, Lei   +6 more
openaire   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

The 2012 Interlaboratory Comparison of Forensic DNA Typing in Thailand

Journal of Health Science and Medical Research (JHSMR), 2014
Objective: To evaluate the results of the 2012 interlaboratory comparison for forensic deoxyribonucleic acid (DNA) typing including autosomal short tandem repeat loci (aSTR), Y-chromosome short tandem repeat loci (Y-STR), X-chromosome short tandem repeat
Nonglak Sinkhan, Weawgarn Duangshatome, Wiparat Jaitrong, Kwanjai Kumyos, Rapeeporn Khienthong, Chalampoo Wongvoravivat, Tanin Bhoopat, Kanha Muisuk, Janpen Thanakitgosate, Chairat Manasatienkij, Kawin Rasmeepaisarn, Jintana Pradutkanchana, Suwit Rueangkittisakul, Budsaba Rerkamnuaychoke, Sukone Pradutkanchana   +14 more
doaj  

Genetic Polymorphisms and Mutations of 30 Y-STR Loci in Chinese Han Population [PDF]

Fayixue Zazhi, 2018
Objective To investigate the genetic polymorphisms and mutations of 30 Y-STR loci in Chinese Han males and to evaluate its forensic application. Methods The DNA extracted from blood samples of 1 005 unrelated males and 1 008 father-son pairs （1 949 ...
WU Wei-wei, SU Yan-jia, MEI Xing-lin，et al.
doaj   +1 more source

Y STR haplotype diversity in central Indian population

Annals of Human Biology, 2015
Seventeen Y-STR loci (DYS19, DYS389I, DYS389II, DYS390, DYS391, DYS392, DYS393, DYS385a/b, DYS437, DYS438, DYS439, DYS448, DYS456, DYS458, DYS635 and Y-GATA-H4) were analysed in 173 males belonging to the central Indian population with the aim of studying genetic diversity and adding to the population database.Multiplexed PCR amplifications of the 17 Y
Pankaj, Shrivastava, Umang, Gupta, Toshi, Jain, Veena Ben, Trivedi   +3 more
openaire   +2 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source