Results 51 to 60 of about 202,867 (255)

Y-STR diversity and ethnic admixture in White and Mulatto Brazilian population samples

Genetics and Molecular Biology, 2006
We investigated 50 Mulatto and 120 White Brazilians for the Y-chromosome short tandem repeat (Y-STR) markers (DYS19, DYS390, DYS391, DYS392 and DYS393) and found 79 different haplotypes in the White and 35 in the Mulatto sample. Admixture estimates based
Luzitano Brandão Ferreira, Celso Teixeira Mendes-Junior, Cláudia Emília Vieira Wiezel, Marcelo Rizzatti Luizon, Aguinaldo Luiz Simões   +4 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Genetic diversities of 23 Y-Chromosome short tandem repeat loci in a han population in the Beijing Region

Journal of Forensic Science and Medicine, 2018
We investigated the polymorphisms of 23 Y-short tandem repeat (STR) loci in a Han population in the Beijing region. Blood samples were collected from 255 unrelated Han males.
Shicheng Hao, Xuan Zhang, Yan Liu, Di Lu
doaj   +1 more source

Validation of a multiplex amplification system of 19 autosomal STRs and 27 Y-STRs

Forensic Sciences Research, 2020
This article describes a newly devised autosomal short tandem repeat (STR) multiplex polymerase chain reaction (PCR) system for 19 autosomal loci (D12S391, D13S317, D16S539, D18S51, D19S433, D2S1338, D21S11, D3S1358, D5S818, D6S1043, D7S820, D8S1179 ...
Feng Liu, Fei Jia, Fang Sun, Bin Zhao, Hongying Shen   +4 more
doaj   +1 more source

Application of Multiple Kits in Special Parentage Testing Cases [PDF]

Fayixue Zazhi, 2018
Objective To analyse the genetic polymorphism of 21 autosome STR loci in Han population of Shandong Province and the cases with loci mutation or allelic loss typed by Goldeneye?誖DNA identification system 25A. Methods Totally 40 autosome STR loci types of
GAO Hong-mei, WANG Chang, ZHANG Shan-shan，et al.
doaj   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Developmental validation of the EX16+22Y system

Journal of Forensic Science and Medicine, 2020
The EX16+22Y system is a polymerase chain reaction (PCR)-based amplification kit that enables typing of 15 autosomal short tandem repeat (STR) loci (i.e., D3S1358, D13S317, D7S820, D16S539, TPOX, TH01, D2S1338, CSF1PO, D19S433, vWA, D18S51, D21S11 ...
Xin Wang, Weizhong Chen, Jian Zhang, Yang Cui, Jingjing Chen, Yunjie Shi, Gao Wang, Fayuan Li, Yong Liu, Ruhua Zhou   +9 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Efficiency Analysis of EX16+10Y Kit on Detection of the Uygur Population in Xinjiang Province [PDF]

Fayixue Zazhi, 2018
Objective To analyse the efficiency of EX16+10Y kit on the forensic detection of the Uygur in Xinjiang province. Methods The blood samples were extracted from 4 620 male individuals of Uygur in Xinjiang province, and amplified by EX16+10Y kit. The typing
BI Gang, ZHANG Chen, DONG Yan, et al
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source