Results 131 to 140 of about 10,690,340 (404)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

Molecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak, Żaneta Zarębska, Marcin P. Sajek, Adriana Grabowska, Alessia Buratin, Paweł Głodowicz, Julia O. Misiorek, Konrad Kuczyński, Stefania Bortoluzzi, Marek Żywicki, Jan G. Kosiński, Agnieszka Rybak‐Wolf, Rafał Piestrzeniewicz, Anna M. Barciszewska, Katarzyna Rolle   +14 more
wiley   +1 more source

The complete sequence of a human Y chromosome

bioRxiv, 2023
A. Rhie, S. Nurk, Monika Cechova, Savannah J. Hoyt, Dylan J. Taylor, Nicolas Altemose, P. Hook, S. Koren, M. Rautiainen, I. Alexandrov, J. Allen, Mobin Asri, A. Bzikadze, Nae-Chyun Chen, Chen-Shan Chin, M. Diekhans, Paul Flicek, G. Formenti, Arkarachai Fungtammasan, C. G. Girón, Erik K. Garrison, Ariel Gershman, J. Gerton, Patrick G. S. Grady, A. Guarracino, Leanne Haggerty, R. Halabian, Nancy F. Hansen, Robert S. Harris, Gabrielle Hartley, William T. Harvey, Marina Haukness, Jakob M. Heinz, Thibaut Hourlier, R. Hubley, S. Hunt, Stephen Hwang, Miten Jain, Rupesh K. Kesharwani, Alexandra P. Lewis, Heng Li, Glennis A. Logsdon, Julian K. Lucas, W. Makałowski, C. Markovic, Fergal J. Martin, Ann M. Mc Cartney, R. McCoy, Jennifer McDaniel, B. McNulty, P. Medvedev, Alla Mikheenko, Katherine M. Munson, T. Murphy, Hugh E. Olsen, Nathan D. Olson, L. F. Paulin, David Porubsky, T. Potapova, Fedor Ryabov, S. Salzberg, M. Sauria, F. Sedlazeck, Kishwar Shafin, V. Shepelev, Alaina Shumate, Jessica M. Storer, Likhitha Surapaneni, Angela M. Taravella Oill, F. Thibaud-Nissen, W. Timp, Marta Tomaszkiewicz, Mitchell R. Vollger, B. Walenz, Allison C. Watwood, Matthias H. Weissensteiner, A. Wenger, Melissa A. Wilson, Samantha Zarate, Yiming Zhu, J. Zook, E. Eichler, R. O’Neill, M. Schatz, K. Miga, K. Makova, A. Phillippy   +86 more
semanticscholar   +1 more source

Purifying Selection Maintains Dosage-Sensitive Genes during Degeneration of the Threespine Stickleback Y Chromosome.

Molecular biology and evolution, 2015
Sex chromosomes are subject to unique evolutionary forces that cause suppression of recombination, leading to sequence degeneration and the formation of heteromorphic chromosome pairs (i.e., XY or ZW).
M. White, J. Kitano, C. L. Peichel
semanticscholar   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Analysis of Y Chromosome Microdeletion in Indonesian Males

Makara Journal of Health Research, 2010
The aim of this study is to find out Y chromosome microdeletion in Indonesian azoospermic men. This study used the PCR method with five STS to locate deletion on three different subregions (AZFa, AZFb, and AZFc) of azoospermic men and one STS to amplify ...
Dwi Anita Suryandari, Yurnadi Yunardi, Puji Sari   +2 more
doaj   +1 more source

Y chromosome loss in cancer drives growth by evasion of adaptive immunity

Nature, 2023
Hany A. Abdel-Hafiz, J. Schafer, Xingyu Chen, Tong Xiao, T. Gauntner, Zihai Li, D. Theodorescu   +6 more
semanticscholar   +1 more source

Roles of the Y chromosome genes in human cancers

Asian Journal of Andrology, 2015
Male and female differ genetically by their respective sex chromosome composition, that is, XY as male and XX as female. Although both X and Y chromosomes evolved from the same ancestor pair of autosomes, the Y chromosome harbors male-specific genes ...
T. Kido, Yun-Fai Chris Lau
semanticscholar   +1 more source

\u3cem\u3eAnolis\u3c/em\u3e Sex Chromosomes Are Derived from A Single Ancestral Pair [PDF]

, 2014
To explain the frequency and distribution of heteromorphic sex chromosomes in the lizard genus Anolis, we compared the relative roles of sex chromosome conservation versus turnover of sex‐determining mechanisms. We used model‐based comparative methods to
Gamble, Tony, Geneva, Anthony J., Glor, Richard E., Zarkower, David   +3 more
core   +1 more source

Morphological detection of X- and Y-chromosomes in smears and paraffin-embedded tissues using a non-isotopic in situ hybridization technique (NISH) [PDF]

, 1994
Pharyngeal smears and paraffin-embedded tissue specimens (skeletal muscle, kidney) obtained from 10 male and 10 female individuals were evaluated using non-isotopic in situ hybridization (NISH) with commercial X- and Y-specific biotinylated probes which ...
Baretton, G., Betz, P., Eisenmenger, Wolfgang, Nerlich, A., Tübel, J.   +4 more
core   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source