Results 131 to 140 of about 5,418 (159)

CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1 [PDF]

Signal Transduction and Targeted Therapy, 2020
AbstractSorafenib is the first-line chemotherapeutic therapy for advanced hepatocellular carcinoma (HCC). However, sorafenib resistance significantly limits its therapeutic efficacy, and the mechanisms underlying resistance have not been fully clarified. Here we report that a circular RNA, circRNA-SORE (a circular RNA upregulated in sorafenib-resistant
Junjie Xu, Wei Zheng, Kirill Gorshkov
exaly   +4 more sources

Ybx1 fine-tunes PRC2 activities to control embryonic brain development [PDF]

Nature Communications, 2020
AbstractChromatin modifiers affect spatiotemporal gene expression programs that underlie organismal development. The Polycomb repressive complex 2 (PRC2) is a crucial chromatin modifier in executing neurodevelopmental programs. Here, we find that PRC2 interacts with the nucleic acid–binding protein Ybx1.
Myron K Evans Ii, Yurika Matsui, Beisi Xu   +2 more
exaly   +4 more sources

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Proteomic analysis of zebrafish folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian folliculogenesis

Biology of Reproduction, 2023
Abstract As in mammals, ovarian folliculogenesis in teleosts also consists of two phases: the primary growth (PG) and secondary growth (SG) phases, which are analogous to the preantral and antral phases respectively in mammals. In this study, we performed a proteomic analysis on zebrafish follicles undergoing the PG–SG transition aiming ...
Esther Shuk-Wa, Lau, Bo, Zhu, Ming-An, Sun, Sai Ming, Ngai, Wei, Ge   +4 more
openaire   +2 more sources

Pathogenetic Significance of YBX1 Expression in Acute Myeloid Leukemia Relapse

Current Research in Translational Medicine, 2022
Genomic abnormalities were established as prognostic and diagnostic markers for acute myeloid leukemia (AML) tumorgenesis and YBX1 gene has important roles in different cancer types.A total of 109 adult and pediatric patients with De novo AML, were enrolled in this study.
Mahmoud B Y, Gouda, Naglaa M, Hassan, Eman I, Kandil, Riham Abdel-Hamid, Haroun   +3 more
openaire   +2 more sources

Endogenous tRNA-Derived Fragments Suppress Breast Cancer Progression via YBX1 Displacement [PDF]

Cell, 2015
Upon exposure to stress, tRNAs are enzymatically cleaved, yielding distinct classes of tRNA-derived fragments (tRFs), yielding distinct classes of tRFs. We identify a novel class of tRFs derived from tRNA(Glu), tRNA(Asp), tRNA(Gly), and tRNA(Tyr) that, upon induction, suppress the stability of multiple oncogenic transcripts in breast cancer cells by ...
Hani Goodarzi, Xuhang Liu, Hoang C B Nguyen   +2 more
exaly   +5 more sources

YBX1 Promotes MSC Osteogenic Differentiation by Activating the PI3K/AKT Pathway

Current Stem Cell Research & Therapy, 2023
Introduction: Bone metabolism has an essential role in the bone disease, but its specific mechanism remains unclear. Y-Box Binding Protein 1 (YBX1) is a gene with broad nucleic acid binding properties, which encodes a highly conserved cold shock domain protein. Previous studies have shown that YBX1 is closely related to cell differentiation.
Jiayu, Chen, Zhanliang, Liu, Huicheng, Zhang, Yongqian, Yang, Huangxiang, Zeng, Rongwei, Zhong, Shangdao, Lai, Hongxing, Liao   +7 more
openaire   +2 more sources

YBX1 knockdown induces renal cell carcinoma cell apoptosis via Kindlin-2

Cell Cycle, 2021
Among urological tumors, renal cell carcinoma (RCC) is the third-highest mortality rate tumor, and 20%-30% of RCC patients present with metastases at the time of diagnosis. While the treatment of RCC has been improved over the last few years, its mortality stays high.
Qiqi, Cui, Chao, Wang, Shuang, Liu, Runxuan, Du, Shaoping, Tian, Ruibing, Chen, Hua, Geng, Saravanan, Subramanian, Yuanjie, Niu, Yong, Wang, Dan, Yue   +10 more
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YBX1 expression and function in early hematopoiesis and leukemic cells

Immunogenetics, 2011
Hematopoietic transcription factors play a critical role in directing the commitment and differentiation of hematopoietic stem cells along a particular lineage. Y-box protein (YBX1) is a transcription factor which is widely expressed throughout development and is involved in erythroid cell development; however, its role in early hematopoietic ...
Jasjeet, Bhullar, Vincent E, Sollars
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CD4 + T cells promote renal cell carcinoma proliferation via modulating YBX1

Experimental Cell Research, 2018
Renal cell carcinoma (RCC) is a common urologic tumor and the third leading cause of death among urological tumors. Recent studies demonstrate that RCC tumors are more heavily infiltrated by lymphocytes than other cancers. However, the exact roles played by CD4 + T cells in RCC proliferation remain unknown.
Yong, Wang, Yiting, Wang, Liang, Xu, Xianqi, Lu, Donghe, Fu, Jing, Su, Hua, Geng, Guoxuan, Qin, Ruibing, Chen, Changyi, Quan, Yuanjie, Niu, Dan, Yue   +11 more
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The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1

Life Sciences
Ubiquitin specific peptidase 5 (USP5), a member of deubiquitinating enzymes, has garnered significant attention for its crucial role in cancer progression. This study aims to explore the role of USP5 and its potential molecular mechanisms in cholangiocarcinoma (CCA).To explore the effect of USP5 on CCA, gain-of-function and loss-of-function assays were
Fengling, Ning, Ling, Du, Jiayang, Li, Tiangang, Wu, Jiacheng, Zhou, Zihui, Chen, Xuetao, Hu, Yuai, Zhang, Xin, Luan, Hong, Xin, Chunyan, Yuan, Xuemei, Zhang   +11 more
openaire   +2 more sources