Results 171 to 180 of about 6,571 (196)

The Pleiotropic Effects of YBX1 on HTLV-1 Transcription

International Journal of Molecular Sciences, 2023
HTLV-1 is an oncogenic human retrovirus and the etiologic agent of the highly aggressive ATL malignancy. Two viral genes, Tax and Hbz, are individually linked to oncogenic transformation and play an important role in the pathogenic process. Consequently,
Pooja Jain, Amanda R Panfil, Yu-Ci Syu
exaly   +4 more sources

YBX1: A Multifunctional Protein in Senescence and Immune Regulation

Current Issues in Molecular Biology
The Y-box binding protein 1 (YBX1) is a multifunctional protein with a wide range of roles in cell biology. It plays a crucial role in immune modulation, senescence, and disease progression.
Wanxia Wang
exaly   +5 more sources

Aurora Kinase A-YBX1 Synergy Fuels Aggressive Oncogenic Phenotypes and Chemoresistance in Castration-Resistant Prostate Cancer

Cancers, 2020
Multifunctional protein YBX1 upregulation promotes castration-resistant prostate cancer (CRPC). However, YBX1 protein abundance, but not its DNA status or mRNA levels, predicts CRPC recurrence, although the mechanism remains unknown.
Kavita Shah, Asif Raza, Asif Raza
exaly   +2 more sources

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Proteomic analysis of zebrafish folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian folliculogenesis

Biology of Reproduction, 2023
Abstract As in mammals, ovarian folliculogenesis in teleosts also consists of two phases: the primary growth (PG) and secondary growth (SG) phases, which are analogous to the preantral and antral phases respectively in mammals. In this study, we performed a proteomic analysis on zebrafish follicles undergoing the PG–SG transition aiming ...
Esther Shuk-Wa, Lau, Bo, Zhu, Ming-An, Sun, Sai Ming, Ngai, Wei, Ge   +4 more
openaire   +2 more sources

Pathogenetic Significance of YBX1 Expression in Acute Myeloid Leukemia Relapse

Current Research in Translational Medicine, 2022
Genomic abnormalities were established as prognostic and diagnostic markers for acute myeloid leukemia (AML) tumorgenesis and YBX1 gene has important roles in different cancer types.A total of 109 adult and pediatric patients with De novo AML, were enrolled in this study.
Mahmoud B Y, Gouda, Naglaa M, Hassan, Eman I, Kandil, Riham Abdel-Hamid, Haroun   +3 more
openaire   +2 more sources

YBX1 at the crossroads of non-coding transcriptome, exosomal, and cytoplasmic granular signaling

European Journal of Cell Biology, 2018
YBX1 (Y box binding protein 1) is an RNA-/DNA-binding multifunctional protein harboring the classical cold shock protein (CSD) domain, an A/P domain, and a long C-terminal domain with alternating positively and negatively charged amino acids. It is a well-established oncogenic transcriptional factor, and regulates apoptosis, translation, cell ...
Rie Tsutsumi, Thejaswini Venkatesh, Padmanaban S Suresh   +2 more
exaly   +3 more sources

The functions and regulation of transcription factor YBX1 in cancers

Molecular Biology Reports
YBX1 is a DNA-binding and RNA-binding protein notable for its evolutionarily conserved cold shock domain. It is located in both the cytoplasm and nucleus and participates in various biological processes, including pre-mRNA splicing, transcription, translation, DNA damage repair, and mRNA stability.
Aixin, Qiu, Yue, Zhang, Yihan, Dong, Dan, Yue, Yang, Yu   +4 more
openaire   +2 more sources

The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1

Life Sciences
Ubiquitin specific peptidase 5 (USP5), a member of deubiquitinating enzymes, has garnered significant attention for its crucial role in cancer progression. This study aims to explore the role of USP5 and its potential molecular mechanisms in cholangiocarcinoma (CCA).To explore the effect of USP5 on CCA, gain-of-function and loss-of-function assays were
Fengling, Ning, Ling, Du, Jiayang, Li, Tiangang, Wu, Jiacheng, Zhou, Zihui, Chen, Xuetao, Hu, Yuai, Zhang, Xin, Luan, Hong, Xin, Chunyan, Yuan, Xuemei, Zhang   +11 more
openaire   +2 more sources

YBX1 Modulates 8-Oxoguanine Recognition and Repair in DNA

ACS Chemical Biology
8-Oxoguanine (8-oxoG) is not only a biomarker of oxidative DNA damage but also an epigenetic-like regulator in mammalian cells. The identification and characterization of 8-oxoG-binding proteins would be crucial for further understanding the biological consequences of 8-oxoG.
Xiaofang Zheng, Weiheng Kong, Xiaoxia Dai, Changjun You   +3 more
openaire   +2 more sources