YBX1 expression and function in early hematopoiesis and leukemic cells
Immunogenetics, 2011Hematopoietic transcription factors play a critical role in directing the commitment and differentiation of hematopoietic stem cells along a particular lineage. Y-box protein (YBX1) is a transcription factor which is widely expressed throughout development and is involved in erythroid cell development; however, its role in early hematopoietic ...
Jasjeet, Bhullar, Vincent E, Sollars
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CD4 + T cells promote renal cell carcinoma proliferation via modulating YBX1
Experimental Cell Research, 2018Renal cell carcinoma (RCC) is a common urologic tumor and the third leading cause of death among urological tumors. Recent studies demonstrate that RCC tumors are more heavily infiltrated by lymphocytes than other cancers. However, the exact roles played by CD4 + T cells in RCC proliferation remain unknown.
Yong, Wang +11 more
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The deubiquitinase USP5 promotes cholangiocarcinoma progression by stabilizing YBX1
Life SciencesUbiquitin specific peptidase 5 (USP5), a member of deubiquitinating enzymes, has garnered significant attention for its crucial role in cancer progression. This study aims to explore the role of USP5 and its potential molecular mechanisms in cholangiocarcinoma (CCA).To explore the effect of USP5 on CCA, gain-of-function and loss-of-function assays were
Fengling, Ning +11 more
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YBX1 Modulates 8-Oxoguanine Recognition and Repair in DNA
ACS Chemical Biology8-Oxoguanine (8-oxoG) is not only a biomarker of oxidative DNA damage but also an epigenetic-like regulator in mammalian cells. The identification and characterization of 8-oxoG-binding proteins would be crucial for further understanding the biological consequences of 8-oxoG.
Xiaofang Zheng +3 more
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Mechanism of Endogenous Peptide PDYBX1 and Precursor Protein YBX1 in Hirschsprung’s Disease
Neuroscience Bulletin, 2023Endogenous peptides, bioactive agents with a small molecular weight and outstanding absorbability, regulate various cellular processes and diseases. However, their role in the occurrence of Hirschsprung's disease (HSCR) remains unclear. Here, we found that the expression of an endogenous peptide derived from YBX1 (termed PDYBX1 in this study) was ...
Qiaochu Sun +6 more
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YBX1 Underwent Phase Separation into Stress Granules Stimulated by Ionizing Radiation
Radiation ResearchStress granules (SGs) are formed through liquid-liquid phase separation (LLPS), in response to external stimuli. YBX1, an integral component of SGs, plays a crucial role in tumor progression and cellular stress response. This study aims to elucidate the mechanisms and specific biological implications of YBX1 in SG formation, along with the ...
Jiaxin, Tang +4 more
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USP47 stabilizes YBX1 to promote the progression of acute myeloid leukemia
Oncogene, 2023Hu Lei +5 more
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1372 Modulation of YBX1 phosphorylation determines epidermal stem cell function
Journal of Investigative Dermatology, 2023S. Sol +3 more
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ISID1372 - Modulation of YBX1 phosphorylation determines epidermal stem cell function.
2023Kristina Todorova +3 more
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The functions and regulation of transcription factor YBX1 in cancers
Molecular Biology ReportsAixin Qiu +4 more
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